ANAPC15 — 9 ClinVar variants
All ClinVar germline ANAPC15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
3 Likely benign · 6 Uncertain significance
Full ANAPC15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All ANAPC15 variants
Likely benign 3
- p.Asp64= Single submitter
- p.Asp72= Single submitter
- p.Glu71Asp Single submitter
Uncertain significance 6
- p.Pro99Leu Multiple submitters autosomal recessive nonsyndromic hearing loss 63 ⚠
- p.Asp72Tyr Single submitter ⚠
- p.Glu113Gln Single submitter ⚠
- p.Ile54Thr Single submitter ⚠
- p.Met89Thr Single submitter ⚠
- p.Ser76Thr Single submitter ⚠