ANAPC16 — 9 ClinVar variants
All ClinVar germline ANAPC16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
9 Uncertain significance
Full ANAPC16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 5
The independent predictors disagree with each other — read with care.
All ANAPC16 variants
Uncertain significance 9
- p.Ala29Asp Single submitter ⚠
- p.Ala29Thr Single submitter ⚠
- p.Arg95Gln Single submitter ⚠
- p.Asp92Glu Single submitter ⚠
- p.Gly43Glu Single submitter ⚠
- p.Gly84Asp Single submitter ⚠
- p.Phe59Leu Single submitter ⚠
- p.Thr106Ile Single submitter
- p.Val76Ile Single submitter ⚠