ANAPC2 — 77 ClinVar variants

All ClinVar germline ANAPC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →

1 Benign · 1 Benign/Likely benign · 2 Likely benign · 73 Uncertain significance

Full ANAPC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 73

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 40

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 33

The independent predictors disagree with each other — read with care.

All ANAPC2 variants

Benign 1

p.Tyr509= Multiple submitters

Benign/Likely benign 1

p.Ala664= Multiple submitters

Likely benign 2

p.Glu152Lys Single submitter
p.Ser697= Single submitter

Uncertain significance 73

p.Ala36Val Single submitter ⚠
p.Ala380Asp Single submitter ⚠
p.Ala4Val Single submitter ⚠
p.Arg121Leu Single submitter ⚠
p.Arg210His Single submitter ⚠
p.Arg270Gln Single submitter ⚠
p.Arg270Trp Single submitter ⚠
p.Arg272Ser Single submitter ⚠
p.Arg287Cys Single submitter ⚠
p.Arg323Cys Single submitter ⚠
p.Arg323His Single submitter ⚠
p.Arg330Ser Single submitter ⚠
p.Arg426His Single submitter ⚠
p.Arg426Leu Single submitter ⚠
p.Arg568Cys Single submitter ⚠
p.Arg568His Single submitter ⚠
p.Arg56Gln Single submitter ⚠
p.Arg575Gln Single submitter ⚠
p.Arg778His Single submitter ⚠
p.Asn573Ser Single submitter ⚠
p.Asn86Ser Single submitter ⚠
p.Asp13His Single submitter ⚠
p.Asp745Asn Single submitter ⚠
p.Cys821Tyr Single submitter ⚠
p.Gln673Arg Single submitter ⚠
p.Gln759Lys Single submitter ⚠
p.Glu19Lys Single submitter ⚠
p.Glu577Gly Single submitter ⚠
p.Glu585Gln Single submitter ⚠
p.Glu679Lys Single submitter ⚠
p.Glu708Asp Single submitter ⚠
p.Glu749Gly Single submitter ⚠
p.Glu9Lys Single submitter ⚠
p.Gly148Glu Single submitter ⚠
p.Gly301Ala Single submitter ⚠
p.Gly301Ser Single submitter ⚠
p.Gly308Ser Single submitter ⚠
p.Gly390Ala Single submitter ⚠
p.Gly590Arg Single submitter ⚠
p.Gly711Ser Single submitter ⚠
p.Gly739Ser Single submitter ⚠
p.Ile730Val Single submitter ⚠
p.Ile773Val Single submitter ⚠
p.Leu220Met Single submitter ⚠
p.Leu382Val Single submitter ⚠
p.Leu668Met Single submitter ⚠
p.Leu729Pro Single submitter ⚠
p.Met687Ile Single submitter ⚠
p.Met761Val Single submitter ⚠
p.Phe331Ser Single submitter ⚠
p.Phe589Leu Single submitter ⚠
p.Pro124Arg Single submitter ⚠
p.Pro219Gln Single submitter ⚠
p.Pro315Leu Single submitter ⚠
p.Pro389Thr Single submitter ⚠
p.Pro489Ala Single submitter ⚠
p.Pro582Ser Single submitter ⚠
p.Pro688Ala Single submitter ⚠
p.Ser338Ile Single submitter ⚠
p.Ser45Arg Single submitter ⚠
p.Ser463Thr Single submitter ⚠
p.Ser499Leu Single submitter ⚠
p.Ser811Leu Single submitter ⚠
p.Thr398Ser Single submitter ⚠
p.Thr449Ser Single submitter ⚠
p.Thr712Ala Single submitter ⚠
p.Thr756Met Single submitter ⚠
p.Val22Gly Single submitter ⚠
p.Val27Met Single submitter ⚠
p.Val594Gly Single submitter ⚠
p.Val685Ala Single submitter ⚠
p.Val7Ala Single submitter ⚠
p.Val7Leu Single submitter ⚠