ANAPC4 — 78 ClinVar variants
All ClinVar germline ANAPC4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
2 Likely benign · 76 Uncertain significance
Full ANAPC4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANAPC4 p.Ala389Ser Uncertain significance Single submitter
- ANAPC4 p.Ala626Thr Uncertain significance Single submitter
- ANAPC4 p.Ala781Ser Uncertain significance Single submitter
- ANAPC4 p.Ala790Thr Uncertain significance Single submitter
- ANAPC4 p.Ala81Val Uncertain significance Single submitter
- ANAPC4 p.Ala85Val Uncertain significance Single submitter
- ANAPC4 p.Arg250Gln Uncertain significance Single submitter
- ANAPC4 p.Arg3Pro Uncertain significance Single submitter
- ANAPC4 p.Arg567Cys Uncertain significance Single submitter
- ANAPC4 p.Arg567His Uncertain significance Single submitter
- ANAPC4 p.Arg567Leu Uncertain significance Single submitter
- ANAPC4 p.Arg567Ser Uncertain significance Single submitter
- ANAPC4 p.Arg659His Uncertain significance Single submitter
- ANAPC4 p.Arg703Cys Uncertain significance Single submitter
- ANAPC4 p.Asn266His Uncertain significance Single submitter
- ANAPC4 p.Asn39Ser Uncertain significance Single submitter
- ANAPC4 p.Asn457Ser Uncertain significance Single submitter
- ANAPC4 p.Asn503His Uncertain significance Single submitter
- ANAPC4 p.Asn531Ser Uncertain significance Single submitter
- ANAPC4 p.Asn549Lys Uncertain significance Single submitter
- ANAPC4 p.Asn766Lys Uncertain significance Single submitter
- ANAPC4 p.Asp162Gly Uncertain significance Single submitter
- ANAPC4 p.Asp382Gly Uncertain significance Single submitter
- ANAPC4 p.Asp499Glu Uncertain significance Single submitter
- ANAPC4 p.Asp755Asn Uncertain significance Single submitter
- ANAPC4 p.Asp759Glu Uncertain significance Single submitter
- ANAPC4 p.Cys271Ser Uncertain significance Single submitter
- ANAPC4 p.Gln442Glu Uncertain significance Single submitter
- ANAPC4 p.Gln535His Uncertain significance Single submitter
- ANAPC4 p.Gln784Pro Uncertain significance Single submitter
- ANAPC4 p.Gln785Lys Uncertain significance Single submitter
- ANAPC4 p.Glu402Gly Uncertain significance Single submitter
- ANAPC4 p.Glu763Asp Uncertain significance Single submitter
- ANAPC4 p.Glu794Asp Uncertain significance Single submitter
- ANAPC4 p.Gly227Asp Uncertain significance Single submitter
- ANAPC4 p.Ile607Thr Uncertain significance Single submitter
- ANAPC4 p.Ile748Met Uncertain significance Single submitter
- ANAPC4 p.Leu522Ser Uncertain significance Single submitter
- ANAPC4 p.Lys709Thr Uncertain significance Single submitter
- ANAPC4 p.Phe234Ile Uncertain significance Single submitter
- ANAPC4 p.Ser103Phe Uncertain significance Single submitter
- ANAPC4 p.Ser339Leu Uncertain significance Single submitter
- ANAPC4 p.Ser364Asn Uncertain significance Single submitter
- ANAPC4 p.Ser594Ala Uncertain significance Single submitter
- ANAPC4 p.Ser677Gly Uncertain significance Single submitter
- ANAPC4 p.Ser757Pro Uncertain significance Single submitter
- ANAPC4 p.Ser777Leu Uncertain significance Single submitter
- ANAPC4 p.Thr270Ser Uncertain significance Single submitter
- ANAPC4 p.Thr391Ile Uncertain significance Single submitter
- ANAPC4 p.Thr40Ala Uncertain significance Single submitter
- ANAPC4 p.Thr64Ile Uncertain significance Single submitter
- ANAPC4 p.Tyr190Ser Uncertain significance Single submitter
- ANAPC4 p.Tyr463Cys Uncertain significance Single submitter
- ANAPC4 p.Tyr516Ser Uncertain significance Single submitter
- ANAPC4 p.Tyr625Cys Uncertain significance Single submitter
- ANAPC4 p.Tyr721His Uncertain significance Single submitter
- ANAPC4 p.Val177Ile Uncertain significance Single submitter
- ANAPC4 p.Val406Ile Uncertain significance Single submitter
- ANAPC4 p.Val472Ile Uncertain significance Single submitter
- ANAPC4 p.Val741Leu Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- ANAPC4 p.Arg419Trp Uncertain significance Single submitter
- ANAPC4 p.Asp485Gly Uncertain significance Single submitter
- ANAPC4 p.Gln345Arg Uncertain significance Single submitter
- ANAPC4 p.Glu780Lys Uncertain significance Single submitter
- ANAPC4 p.Gly467Glu Uncertain significance Single submitter
- ANAPC4 p.His584Arg Uncertain significance Single submitter
- ANAPC4 p.Leu138Pro Uncertain significance Single submitter
- ANAPC4 p.Lys294Asn Uncertain significance Single submitter
- ANAPC4 p.Lys294Glu Uncertain significance Single submitter
- ANAPC4 p.Lys346Gln Uncertain significance Single submitter
- ANAPC4 p.Lys439Glu Uncertain significance Single submitter
- ANAPC4 p.Phe290Leu Uncertain significance Single submitter
- ANAPC4 p.Ser342Tyr Uncertain significance Single submitter
All ANAPC4 variants
Likely benign 2
- p.Asn226Ser Single submitter
- p.Ile618Val Single submitter
Uncertain significance 76
- c.515+1G>A Single submitter
- p.Ala389Ser Single submitter ⚠
- p.Ala626Thr Single submitter ⚠
- p.Ala781Ser Single submitter ⚠
- p.Ala790Thr Single submitter ⚠
- p.Ala81Val Single submitter ⚠
- p.Ala85Val Single submitter ⚠
- p.Arg250Gln Single submitter ⚠
- p.Arg250Trp Single submitter
- p.Arg3Pro Single submitter ⚠
- p.Arg419Trp Single submitter ⚠
- p.Arg567Cys Single submitter ⚠
- p.Arg567His Single submitter ⚠
- p.Arg567Leu Single submitter ⚠
- p.Arg567Ser Single submitter ⚠
- p.Arg659His Single submitter ⚠
- p.Arg703Cys Single submitter ⚠
- p.Asn266His Single submitter ⚠
- p.Asn39Ser Single submitter ⚠
- p.Asn457Ser Single submitter ⚠
- p.Asn503His Single submitter ⚠
- p.Asn531Ser Single submitter ⚠
- p.Asn549Lys Single submitter ⚠
- p.Asn766Lys Single submitter ⚠
- p.Asp162Gly Single submitter ⚠
- p.Asp382Gly Single submitter ⚠
- p.Asp485Gly Single submitter ⚠
- p.Asp499Glu Single submitter ⚠
- p.Asp606His Single submitter
- p.Asp755Asn Single submitter ⚠
- p.Asp759Glu Single submitter ⚠
- p.Cys271Ser Single submitter ⚠
- p.Gln345Arg Single submitter ⚠
- p.Gln442Glu Single submitter ⚠
- p.Gln535His Single submitter ⚠
- p.Gln784Pro Single submitter ⚠
- p.Gln785Lys Single submitter ⚠
- p.Glu402Gly Single submitter ⚠
- p.Glu763Asp Single submitter ⚠
- p.Glu780Lys Single submitter ⚠
- p.Glu794Asp Single submitter ⚠
- p.Gly227Asp Single submitter ⚠
- p.Gly467Glu Single submitter ⚠
- p.His584Arg Single submitter ⚠
- p.Ile607Thr Single submitter ⚠
- p.Ile748Met Single submitter ⚠
- p.Leu138Pro Single submitter ⚠
- p.Leu522Ser Single submitter ⚠
- p.Lys294Asn Single submitter ⚠
- p.Lys294Glu Single submitter ⚠
- p.Lys346Gln Single submitter ⚠
- p.Lys439Glu Single submitter ⚠
- p.Lys709Thr Single submitter ⚠
- p.Phe234Ile Single submitter ⚠
- p.Phe290Leu Single submitter ⚠
- p.Ser103Phe Single submitter ⚠
- p.Ser339Leu Single submitter ⚠
- p.Ser342Tyr Single submitter ⚠
- p.Ser364Asn Single submitter ⚠
- p.Ser594Ala Single submitter ⚠
- p.Ser677Gly Single submitter ⚠
- p.Ser757Pro Single submitter ⚠
- p.Ser777Leu Single submitter ⚠
- p.Thr270Ser Single submitter ⚠
- p.Thr391Ile Single submitter ⚠
- p.Thr40Ala Single submitter ⚠
- p.Thr64Ile Single submitter ⚠
- p.Tyr190Ser Single submitter ⚠
- p.Tyr463Cys Single submitter ⚠
- p.Tyr516Ser Single submitter ⚠
- p.Tyr625Cys Single submitter ⚠
- p.Tyr721His Single submitter ⚠
- p.Val177Ile Single submitter ⚠
- p.Val406Ile Single submitter ⚠
- p.Val472Ile Single submitter ⚠
- p.Val741Leu Single submitter ⚠