ANAPC5 — 52 ClinVar variants
All ClinVar germline ANAPC5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
4 Likely benign · 48 Uncertain significance
Full ANAPC5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANAPC5 p.Asn335Ser Uncertain significance Multiple submitters
- ANAPC5 p.Ala173Thr Uncertain significance Single submitter
- ANAPC5 p.Ala478Val Uncertain significance Single submitter
- ANAPC5 p.Ala588Pro Uncertain significance Single submitter
- ANAPC5 p.Ala640Asp Uncertain significance Single submitter
- ANAPC5 p.Ala673Pro Uncertain significance Single submitter
- ANAPC5 p.Arg57Gln Uncertain significance Single submitter
- ANAPC5 p.Arg593Gln Uncertain significance Single submitter
- ANAPC5 p.Arg709Cys Uncertain significance Single submitter
- ANAPC5 p.Asn22Ser Uncertain significance Single submitter
- ANAPC5 p.Asn396Asp Uncertain significance Single submitter
- ANAPC5 p.Asn576Ile Uncertain significance Single submitter
- ANAPC5 p.Asp336Asn Uncertain significance Single submitter
- ANAPC5 p.Asp679Asn Uncertain significance Single submitter
- ANAPC5 p.Gln94His Uncertain significance Single submitter
- ANAPC5 p.Glu182Lys Uncertain significance Single submitter
- ANAPC5 p.Gly121Val Uncertain significance Single submitter
- ANAPC5 p.His370Tyr Uncertain significance Single submitter
- ANAPC5 p.His561Arg Uncertain significance Single submitter
- ANAPC5 p.His722Pro Uncertain significance Single submitter
- ANAPC5 p.His741Tyr Uncertain significance Single submitter
- ANAPC5 p.Ile82Val Uncertain significance Single submitter
- ANAPC5 p.Leu451Pro Uncertain significance Single submitter
- ANAPC5 p.Leu451Val Uncertain significance Single submitter
- ANAPC5 p.Leu538Val Uncertain significance Single submitter
- ANAPC5 p.Leu755Val Uncertain significance Single submitter
- ANAPC5 p.Met44Ile Uncertain significance Single submitter
- ANAPC5 p.Ser144Cys Uncertain significance Single submitter
- ANAPC5 p.Ser147Ala Uncertain significance Single submitter
- ANAPC5 p.Ser530Ala Uncertain significance Single submitter
- ANAPC5 p.Ser53Asn Uncertain significance Single submitter
- ANAPC5 p.Thr533Ile Uncertain significance Single submitter
- ANAPC5 p.Val126Ile Uncertain significance Single submitter
- ANAPC5 p.Val170Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- ANAPC5 p.Ala600Val Uncertain significance Single submitter
- ANAPC5 p.Arg329Lys Uncertain significance Single submitter
- ANAPC5 p.Arg732Trp Uncertain significance Single submitter
- ANAPC5 p.Glu104Lys Uncertain significance Single submitter
- ANAPC5 p.His645Pro Uncertain significance Single submitter
- ANAPC5 p.Pro206Leu Uncertain significance Single submitter
- ANAPC5 p.Pro498Leu Uncertain significance Single submitter
- ANAPC5 p.Pro66Leu Uncertain significance Single submitter
- ANAPC5 p.Ser487Pro Uncertain significance Single submitter
- ANAPC5 p.Tyr432Cys Uncertain significance Single submitter
All ANAPC5 variants
Likely benign 4
- p.Ala308= Single submitter
- p.Lys575Arg Single submitter
- p.Pro681Leu Single submitter
- p.Lys366Arg No assertion criteria ANAPC5-related disorder
Uncertain significance 48
- p.Asn335Ser Multiple submitters ⚠
- c.657+1G>A Single submitter
- p.Ala173Thr Single submitter ⚠
- p.Ala474Thr Single submitter
- p.Ala478Val Single submitter ⚠
- p.Ala588Pro Single submitter ⚠
- p.Ala600Val Single submitter ⚠
- p.Ala640Asp Single submitter ⚠
- p.Ala673Pro Single submitter ⚠
- p.Arg329Lys Single submitter ⚠
- p.Arg57Gln Single submitter ⚠
- p.Arg593Gln Single submitter ⚠
- p.Arg709Cys Single submitter ⚠
- p.Arg732Trp Single submitter ⚠
- p.Asn22Ser Single submitter ⚠
- p.Asn396Asp Single submitter ⚠
- p.Asn576Ile Single submitter ⚠
- p.Asp336Asn Single submitter ⚠
- p.Asp679Asn Single submitter ⚠
- p.Cys733Tyr Single submitter
- p.Gln94His Single submitter ⚠
- p.Glu104Lys Single submitter ⚠
- p.Glu182Lys Single submitter ⚠
- p.Gly121Val Single submitter ⚠
- p.His370Tyr Single submitter ⚠
- p.His561Arg Single submitter ⚠
- p.His645Pro Single submitter ⚠
- p.His722Pro Single submitter ⚠
- p.His741Tyr Single submitter ⚠
- p.Ile82Val Single submitter ⚠
- p.Leu451Pro Single submitter ⚠
- p.Leu451Val Single submitter ⚠
- p.Leu470Phe Single submitter
- p.Leu538Val Single submitter ⚠
- p.Leu755Val Single submitter ⚠
- p.Met44Ile Single submitter ⚠
- p.Pro206Leu Single submitter ⚠
- p.Pro498Leu Single submitter ⚠
- p.Pro66Leu Single submitter ⚠
- p.Ser144Cys Single submitter ⚠
- p.Ser147Ala Single submitter ⚠
- p.Ser487Pro Single submitter ⚠
- p.Ser530Ala Single submitter ⚠
- p.Ser53Asn Single submitter ⚠
- p.Thr533Ile Single submitter ⚠
- p.Tyr432Cys Single submitter ⚠
- p.Val126Ile Single submitter ⚠
- p.Val170Met Single submitter ⚠