ANGEL2 — 64 ClinVar variants
All ClinVar germline ANGEL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 64 flagged for review →
64 Uncertain significance
Full ANGEL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 64
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANGEL2 p.Ala255Thr Uncertain significance Single submitter
- ANGEL2 p.Ala299Thr Uncertain significance Single submitter
- ANGEL2 p.Ala3Gly Uncertain significance Single submitter
- ANGEL2 p.Arg133Trp Uncertain significance Single submitter
- ANGEL2 p.Arg18Gly Uncertain significance Single submitter
- ANGEL2 p.Arg191Gln Uncertain significance Single submitter
- ANGEL2 p.Arg192Gln Uncertain significance Single submitter
- ANGEL2 p.Arg192Trp Uncertain significance Single submitter
- ANGEL2 p.Arg246Gln Uncertain significance Single submitter
- ANGEL2 p.Arg249Gly Uncertain significance Single submitter
- ANGEL2 p.Arg275Leu Uncertain significance Single submitter
- ANGEL2 p.Arg473Gln Uncertain significance Single submitter
- ANGEL2 p.Arg49Ser Uncertain significance Single submitter
- ANGEL2 p.Arg5Pro Uncertain significance Single submitter
- ANGEL2 p.Arg63Gly Uncertain significance Single submitter
- ANGEL2 p.Asn314Ser Uncertain significance Single submitter
- ANGEL2 p.Asn353Ser Uncertain significance Single submitter
- ANGEL2 p.Asn444Asp Uncertain significance Single submitter
- ANGEL2 p.Asn522Ser Uncertain significance Single submitter
- ANGEL2 p.Asp182Asn Uncertain significance Single submitter
- ANGEL2 p.Gly381Ser Uncertain significance Single submitter
- ANGEL2 p.Gly59Arg Uncertain significance Single submitter
- ANGEL2 p.His13Pro Uncertain significance Single submitter
- ANGEL2 p.His141Arg Uncertain significance Single submitter
- ANGEL2 p.His185Tyr Uncertain significance Single submitter
- ANGEL2 p.His310Pro Uncertain significance Single submitter
- ANGEL2 p.His337Leu Uncertain significance Single submitter
- ANGEL2 p.His50Arg Uncertain significance Single submitter
- ANGEL2 p.Ile106Leu Uncertain significance Single submitter
- ANGEL2 p.Ile304Val Uncertain significance Single submitter
- ANGEL2 p.Ile320Val Uncertain significance Single submitter
- ANGEL2 p.Ile346Val Uncertain significance Single submitter
- ANGEL2 p.Ile376Val Uncertain significance Single submitter
- ANGEL2 p.Leu401Arg Uncertain significance Single submitter
- ANGEL2 p.Leu76Ile Uncertain significance Single submitter
- ANGEL2 p.Met113Thr Uncertain significance Single submitter
- ANGEL2 p.Met327Val Uncertain significance Single submitter
- ANGEL2 p.Pro120Ser Uncertain significance Single submitter
- ANGEL2 p.Pro156Ala Uncertain significance Single submitter
- ANGEL2 p.Pro302Ser Uncertain significance Single submitter
- ANGEL2 p.Pro460Leu Uncertain significance Single submitter
- ANGEL2 p.Pro81Leu Uncertain significance Single submitter
- ANGEL2 p.Ser104Phe Uncertain significance Single submitter
- ANGEL2 p.Ser30Asn Uncertain significance Single submitter
- ANGEL2 p.Thr309Met Uncertain significance Single submitter
- ANGEL2 p.Thr462Ser Uncertain significance Single submitter
- ANGEL2 p.Thr514Ala Uncertain significance Single submitter
- ANGEL2 p.Tyr66Cys Uncertain significance Single submitter
- ANGEL2 p.Tyr68Cys Uncertain significance Single submitter
- ANGEL2 p.Val130Met Uncertain significance Single submitter
- ANGEL2 p.Val16Met Uncertain significance Single submitter
- ANGEL2 p.Val306Ile Uncertain significance Single submitter
- ANGEL2 p.Val379Glu Uncertain significance Single submitter
- ANGEL2 p.Val454Ala Uncertain significance Single submitter
- ANGEL2 p.Val498Leu Uncertain significance Single submitter
- ANGEL2 p.Val501Ile Uncertain significance Single submitter
- ANGEL2 p.Val521Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- ANGEL2 p.Arg275Cys Uncertain significance Single submitter
- ANGEL2 p.Gly388Glu Uncertain significance Single submitter
- ANGEL2 p.Gly463Arg Uncertain significance Single submitter
- ANGEL2 p.Leu291Val Uncertain significance Single submitter
- ANGEL2 p.Leu518Phe Uncertain significance Single submitter
- ANGEL2 p.Leu542Val Uncertain significance Single submitter
- ANGEL2 p.Trp519Arg Uncertain significance Single submitter
All ANGEL2 variants
Uncertain significance 64
- p.Ala255Thr Single submitter ⚠
- p.Ala299Thr Single submitter ⚠
- p.Ala3Gly Single submitter ⚠
- p.Arg133Trp Single submitter ⚠
- p.Arg18Gly Single submitter ⚠
- p.Arg191Gln Single submitter ⚠
- p.Arg192Gln Single submitter ⚠
- p.Arg192Trp Single submitter ⚠
- p.Arg246Gln Single submitter ⚠
- p.Arg249Gly Single submitter ⚠
- p.Arg275Cys Single submitter ⚠
- p.Arg275Leu Single submitter ⚠
- p.Arg473Gln Single submitter ⚠
- p.Arg49Ser Single submitter ⚠
- p.Arg5Pro Single submitter ⚠
- p.Arg63Gly Single submitter ⚠
- p.Asn314Ser Single submitter ⚠
- p.Asn353Ser Single submitter ⚠
- p.Asn444Asp Single submitter ⚠
- p.Asn522Ser Single submitter ⚠
- p.Asp182Asn Single submitter ⚠
- p.Gly381Ser Single submitter ⚠
- p.Gly388Glu Single submitter ⚠
- p.Gly463Arg Single submitter ⚠
- p.Gly59Arg Single submitter ⚠
- p.His13Pro Single submitter ⚠
- p.His141Arg Single submitter ⚠
- p.His185Tyr Single submitter ⚠
- p.His310Pro Single submitter ⚠
- p.His337Leu Single submitter ⚠
- p.His50Arg Single submitter ⚠
- p.Ile106Leu Single submitter ⚠
- p.Ile304Val Single submitter ⚠
- p.Ile320Val Single submitter ⚠
- p.Ile346Val Single submitter ⚠
- p.Ile376Val Single submitter ⚠
- p.Leu291Val Single submitter ⚠
- p.Leu401Arg Single submitter ⚠
- p.Leu518Phe Single submitter ⚠
- p.Leu542Val Single submitter ⚠
- p.Leu76Ile Single submitter ⚠
- p.Met113Thr Single submitter ⚠
- p.Met327Val Single submitter ⚠
- p.Pro120Ser Single submitter ⚠
- p.Pro156Ala Single submitter ⚠
- p.Pro302Ser Single submitter ⚠
- p.Pro460Leu Single submitter ⚠
- p.Pro81Leu Single submitter ⚠
- p.Ser104Phe Single submitter ⚠
- p.Ser30Asn Single submitter ⚠
- p.Thr309Met Single submitter ⚠
- p.Thr462Ser Single submitter ⚠
- p.Thr514Ala Single submitter ⚠
- p.Trp519Arg Single submitter ⚠
- p.Tyr66Cys Single submitter ⚠
- p.Tyr68Cys Single submitter ⚠
- p.Val130Met Single submitter ⚠
- p.Val16Met Single submitter ⚠
- p.Val306Ile Single submitter ⚠
- p.Val379Glu Single submitter ⚠
- p.Val454Ala Single submitter ⚠
- p.Val498Leu Single submitter ⚠
- p.Val501Ile Single submitter ⚠
- p.Val521Ile Single submitter ⚠