ANGPTL2 — 70 ClinVar variants
All ClinVar germline ANGPTL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 70 flagged for review →
1 Likely benign · 69 Uncertain significance
Full ANGPTL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 70
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANGPTL2 p.Arg101Gln Uncertain significance Single submitter
- ANGPTL2 p.Arg147His Uncertain significance Single submitter
- ANGPTL2 p.Arg149Trp Uncertain significance Single submitter
- ANGPTL2 p.Arg375Cys Uncertain significance Single submitter
- ANGPTL2 p.Arg399Cys Uncertain significance Single submitter
- ANGPTL2 p.Arg459Trp Uncertain significance Single submitter
- ANGPTL2 p.Arg64Gln Uncertain significance Single submitter
- ANGPTL2 p.Asn490Ser Uncertain significance Single submitter
- ANGPTL2 p.Asp168Asn Uncertain significance Single submitter
- ANGPTL2 p.Cys8Ser Uncertain significance Single submitter
- ANGPTL2 p.Gln193Leu Uncertain significance Single submitter
- ANGPTL2 p.Gln51Leu Uncertain significance Single submitter
- ANGPTL2 p.Glu370Lys Uncertain significance Single submitter
- ANGPTL2 p.Glu391Lys Uncertain significance Single submitter
- ANGPTL2 p.Glu75Asp Uncertain significance Single submitter
- ANGPTL2 p.Gly115Ser Uncertain significance Single submitter
- ANGPTL2 p.Gly18Ala Uncertain significance Single submitter
- ANGPTL2 p.Gly26Ser Uncertain significance Single submitter
- ANGPTL2 p.Gly29Asp Uncertain significance Single submitter
- ANGPTL2 p.Gly29Ser Uncertain significance Single submitter
- ANGPTL2 p.Gly450Arg Uncertain significance Single submitter
- ANGPTL2 p.His85Pro Uncertain significance Single submitter
- ANGPTL2 p.Ile234Val Uncertain significance Single submitter
- ANGPTL2 p.Ile343Thr Uncertain significance Single submitter
- ANGPTL2 p.Lys86Glu Uncertain significance Single submitter
- ANGPTL2 p.Pro222Ser Uncertain significance Single submitter
- ANGPTL2 p.Pro253Thr Uncertain significance Single submitter
- ANGPTL2 p.Pro259Ser Uncertain significance Single submitter
- ANGPTL2 p.Pro3Ser Uncertain significance Single submitter
- ANGPTL2 p.Pro3Thr Uncertain significance Single submitter
- ANGPTL2 p.Pro76Ala Uncertain significance Single submitter
- ANGPTL2 p.Ser34Leu Uncertain significance Single submitter
- ANGPTL2 p.Thr30Ala Uncertain significance Single submitter
- ANGPTL2 p.Val207Ala Uncertain significance Single submitter
- ANGPTL2 p.Val65Ile Uncertain significance Single submitter
- ANGPTL2 p.Val71Ile Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- ANGPTL2 p.Ala190Gly Uncertain significance Single submitter
- ANGPTL2 p.Ala68Asp Uncertain significance Single submitter
- ANGPTL2 p.Arg149Gln Uncertain significance Single submitter
- ANGPTL2 p.Arg223Trp Uncertain significance Single submitter
- ANGPTL2 p.Arg301Cys Uncertain significance Single submitter
- ANGPTL2 p.Arg385His Uncertain significance Single submitter
- ANGPTL2 p.Arg385Leu Uncertain significance Single submitter
- ANGPTL2 p.Arg396Trp Uncertain significance Single submitter
- ANGPTL2 p.Arg46Gln Uncertain significance Single submitter
- ANGPTL2 p.Arg46Trp Uncertain significance Single submitter
- ANGPTL2 p.Arg64Trp Uncertain significance Single submitter
- ANGPTL2 p.Gln102His Uncertain significance Single submitter
- ANGPTL2 p.Gln63Leu Uncertain significance Single submitter
- ANGPTL2 p.Glu104Lys Uncertain significance Single submitter
- ANGPTL2 p.Glu24Lys Likely benign Single submitter
- ANGPTL2 p.Glu380Ala Uncertain significance Single submitter
- ANGPTL2 p.Gly413Ser Uncertain significance Single submitter
- ANGPTL2 p.His423Tyr Uncertain significance Single submitter
- ANGPTL2 p.Ile103Met Uncertain significance Single submitter
- ANGPTL2 p.Ile319Met Uncertain significance Single submitter
- ANGPTL2 p.Ile354Val Uncertain significance Single submitter
- ANGPTL2 p.Ile59Thr Uncertain significance Single submitter
- ANGPTL2 p.Leu97Phe Uncertain significance Single submitter
- ANGPTL2 p.Lys100Asn Uncertain significance Single submitter
- ANGPTL2 p.Pro212Leu Uncertain significance Single submitter
- ANGPTL2 p.Pro221Ser Uncertain significance Single submitter
- ANGPTL2 p.Pro296Leu Uncertain significance Single submitter
- ANGPTL2 p.Ser460Gly Uncertain significance Single submitter
- ANGPTL2 p.Thr105Met Uncertain significance Single submitter
- ANGPTL2 p.Thr268Ile Uncertain significance Single submitter
- ANGPTL2 p.Thr66Met Uncertain significance Single submitter
- ANGPTL2 p.Val250Met Uncertain significance Single submitter
- ANGPTL2 p.Val318Ile Uncertain significance Single submitter
- ANGPTL2 p.Val6Met Uncertain significance Single submitter
All ANGPTL2 variants
Likely benign 1
- p.Glu24Lys Single submitter ⚠
Uncertain significance 69
- p.Ala190Gly Single submitter ⚠
- p.Ala68Asp Single submitter ⚠
- p.Arg101Gln Single submitter ⚠
- p.Arg147His Single submitter ⚠
- p.Arg149Gln Single submitter ⚠
- p.Arg149Trp Single submitter ⚠
- p.Arg223Trp Single submitter ⚠
- p.Arg301Cys Single submitter ⚠
- p.Arg375Cys Single submitter ⚠
- p.Arg385His Single submitter ⚠
- p.Arg385Leu Single submitter ⚠
- p.Arg396Trp Single submitter ⚠
- p.Arg399Cys Single submitter ⚠
- p.Arg459Trp Single submitter ⚠
- p.Arg46Gln Single submitter ⚠
- p.Arg46Trp Single submitter ⚠
- p.Arg64Gln Single submitter ⚠
- p.Arg64Trp Single submitter ⚠
- p.Asn490Ser Single submitter ⚠
- p.Asp168Asn Single submitter ⚠
- p.Cys8Ser Single submitter ⚠
- p.Gln102His Single submitter ⚠
- p.Gln193Leu Single submitter ⚠
- p.Gln51Leu Single submitter ⚠
- p.Gln63Leu Single submitter ⚠
- p.Glu104Lys Single submitter ⚠
- p.Glu370Lys Single submitter ⚠
- p.Glu380Ala Single submitter ⚠
- p.Glu391Lys Single submitter ⚠
- p.Glu75Asp Single submitter ⚠
- p.Gly115Ser Single submitter ⚠
- p.Gly18Ala Single submitter ⚠
- p.Gly26Ser Single submitter ⚠
- p.Gly29Asp Single submitter ⚠
- p.Gly29Ser Single submitter ⚠
- p.Gly413Ser Single submitter ⚠
- p.Gly450Arg Single submitter ⚠
- p.His423Tyr Single submitter ⚠
- p.His85Pro Single submitter ⚠
- p.Ile103Met Single submitter ⚠
- p.Ile234Val Single submitter ⚠
- p.Ile319Met Single submitter ⚠
- p.Ile343Thr Single submitter ⚠
- p.Ile354Val Single submitter ⚠
- p.Ile59Thr Single submitter ⚠
- p.Leu97Phe Single submitter ⚠
- p.Lys100Asn Single submitter ⚠
- p.Lys86Glu Single submitter ⚠
- p.Pro212Leu Single submitter ⚠
- p.Pro221Ser Single submitter ⚠
- p.Pro222Ser Single submitter ⚠
- p.Pro253Thr Single submitter ⚠
- p.Pro259Ser Single submitter ⚠
- p.Pro296Leu Single submitter ⚠
- p.Pro3Ser Single submitter ⚠
- p.Pro3Thr Single submitter ⚠
- p.Pro76Ala Single submitter ⚠
- p.Ser34Leu Single submitter ⚠
- p.Ser460Gly Single submitter ⚠
- p.Thr105Met Single submitter ⚠
- p.Thr268Ile Single submitter ⚠
- p.Thr30Ala Single submitter ⚠
- p.Thr66Met Single submitter ⚠
- p.Val207Ala Single submitter ⚠
- p.Val250Met Single submitter ⚠
- p.Val318Ile Single submitter ⚠
- p.Val65Ile Single submitter ⚠
- p.Val6Met Single submitter ⚠
- p.Val71Ile Single submitter ⚠