ANGPTL5 — 46 ClinVar variants
All ClinVar germline ANGPTL5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
2 Benign · 44 Uncertain significance
Full ANGPTL5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANGPTL5 p.Ala22Val Uncertain significance Single submitter
- ANGPTL5 p.Arg73Leu Uncertain significance Single submitter
- ANGPTL5 p.Asn13Ser Uncertain significance Single submitter
- ANGPTL5 p.Cys338Ser Uncertain significance Single submitter
- ANGPTL5 p.Cys338Tyr Uncertain significance Single submitter
- ANGPTL5 p.Glu21Lys Uncertain significance Single submitter
- ANGPTL5 p.Glu337Lys Uncertain significance Single submitter
- ANGPTL5 p.Gly25Ser Uncertain significance Single submitter
- ANGPTL5 p.Gly288Arg Uncertain significance Single submitter
- ANGPTL5 p.Gly339Val Uncertain significance Single submitter
- ANGPTL5 p.His146Tyr Uncertain significance Single submitter
- ANGPTL5 p.His328Tyr Uncertain significance Single submitter
- ANGPTL5 p.Ile157Thr Uncertain significance Single submitter
- ANGPTL5 p.Leu124Phe Uncertain significance Single submitter
- ANGPTL5 p.Lys162Asn Uncertain significance Single submitter
- ANGPTL5 p.Met242Thr Uncertain significance Single submitter
- ANGPTL5 p.Met273Ile Uncertain significance Single submitter
- ANGPTL5 p.Pro142Leu Uncertain significance Single submitter
- ANGPTL5 p.Pro142Ser Uncertain significance Single submitter
- ANGPTL5 p.Pro142Thr Uncertain significance Single submitter
- ANGPTL5 p.Ser176Thr Uncertain significance Single submitter
- ANGPTL5 p.Thr161Ile Uncertain significance Single submitter
- ANGPTL5 p.Trp360Cys Uncertain significance Single submitter
- ANGPTL5 p.Tyr90Cys Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- ANGPTL5 p.Leu98Pro Benign Multiple submitters
- ANGPTL5 p.Arg132Gly Uncertain significance Single submitter
- ANGPTL5 p.Arg207Lys Uncertain significance Single submitter
- ANGPTL5 p.Asn235Ser Uncertain significance Single submitter
- ANGPTL5 p.Asn317Ser Uncertain significance Single submitter
- ANGPTL5 p.Asp103Gly Uncertain significance Single submitter
- ANGPTL5 p.Cys15Arg Uncertain significance Single submitter
- ANGPTL5 p.Cys314Tyr Uncertain significance Single submitter
- ANGPTL5 p.Gln236Arg Uncertain significance Single submitter
- ANGPTL5 p.Gln295Arg Uncertain significance Single submitter
- ANGPTL5 p.Glu222Gln Uncertain significance Single submitter
- ANGPTL5 p.Gly166Ser Uncertain significance Single submitter
- ANGPTL5 p.Gly332Cys Uncertain significance Single submitter
- ANGPTL5 p.Gly345Asp Uncertain significance Single submitter
- ANGPTL5 p.Gly345Val Uncertain significance Single submitter
- ANGPTL5 p.Ile195Val Uncertain significance Single submitter
- ANGPTL5 p.Leu219Phe Uncertain significance Single submitter
- ANGPTL5 p.Met298Val Uncertain significance Single submitter
- ANGPTL5 p.Met377Val Uncertain significance Single submitter
- ANGPTL5 p.Tyr256His Uncertain significance Single submitter
- ANGPTL5 p.Tyr256Phe Uncertain significance Single submitter
All ANGPTL5 variants
Benign 2
- p.Leu98Pro Multiple submitters ⚠
- p.Asn366fs Single submitter
Uncertain significance 44
- p.Ala22Val Single submitter ⚠
- p.Arg132Gly Single submitter ⚠
- p.Arg207Lys Single submitter ⚠
- p.Arg73Leu Single submitter ⚠
- p.Asn13Ser Single submitter ⚠
- p.Asn235Ser Single submitter ⚠
- p.Asn317Ser Single submitter ⚠
- p.Asp103Gly Single submitter ⚠
- p.Cys15Arg Single submitter ⚠
- p.Cys314Tyr Single submitter ⚠
- p.Cys338Ser Single submitter ⚠
- p.Cys338Tyr Single submitter ⚠
- p.Gln236Arg Single submitter ⚠
- p.Gln295Arg Single submitter ⚠
- p.Glu21Lys Single submitter ⚠
- p.Glu222Gln Single submitter ⚠
- p.Glu337Lys Single submitter ⚠
- p.Gly166Ser Single submitter ⚠
- p.Gly25Ser Single submitter ⚠
- p.Gly288Arg Single submitter ⚠
- p.Gly332Cys Single submitter ⚠
- p.Gly339Val Single submitter ⚠
- p.Gly345Asp Single submitter ⚠
- p.Gly345Val Single submitter ⚠
- p.His146Tyr Single submitter ⚠
- p.His328Tyr Single submitter ⚠
- p.Ile157Thr Single submitter ⚠
- p.Ile195Val Single submitter ⚠
- p.Leu124Phe Single submitter ⚠
- p.Leu219Phe Single submitter ⚠
- p.Lys162Asn Single submitter ⚠
- p.Met242Thr Single submitter ⚠
- p.Met273Ile Single submitter ⚠
- p.Met298Val Single submitter ⚠
- p.Met377Val Single submitter ⚠
- p.Pro142Leu Single submitter ⚠
- p.Pro142Ser Single submitter ⚠
- p.Pro142Thr Single submitter ⚠
- p.Ser176Thr Single submitter ⚠
- p.Thr161Ile Single submitter ⚠
- p.Trp360Cys Single submitter ⚠
- p.Tyr256His Single submitter ⚠
- p.Tyr256Phe Single submitter ⚠
- p.Tyr90Cys Single submitter ⚠