ANGPTL7 — 73 ClinVar variants

All ClinVar germline ANGPTL7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →

1 Conflicting · 1 Benign · 11 Likely benign · 60 Uncertain significance

Full ANGPTL7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 61

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

ANGPTL7 p.Lys345Arg Conflicting Single submitter

Predictors lean, ClinVar uncertain 38

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 22

The independent predictors disagree with each other — read with care.

All ANGPTL7 variants

Conflicting classifications of pathogenicity 1

p.Lys345Arg Single submitter ⚠

Benign 1

p.Arg220Cys Single submitter

Likely benign 11

c.377-3T>C Single submitter
p.Arg211= Single submitter
p.Gln175His Single submitter
p.Leu310= Single submitter
p.Pro23= Single submitter
p.Pro23Ala Single submitter
p.Pro5= Single submitter
p.Thr329= Single submitter
p.Tyr135= Single submitter
p.Tyr232= Single submitter
p.Val335= Single submitter

Uncertain significance 60

p.Arg176Ser Single submitter ⚠
p.Arg211Gln Single submitter ⚠
p.Arg214Ile Single submitter ⚠
p.Arg218Gln Single submitter ⚠
p.Arg220His Single submitter ⚠
p.Arg231Cys Single submitter ⚠
p.Arg289Cys Single submitter ⚠
p.Arg309Cys Single submitter ⚠
p.Arg309His Single submitter ⚠
p.Arg334Trp Single submitter ⚠
p.Arg340Cys Single submitter ⚠
p.Arg340His Single submitter ⚠
p.Arg90Cys Single submitter ⚠
p.Arg90His Single submitter ⚠
p.Arg94Gln Single submitter ⚠
p.Asn302Lys Single submitter ⚠
p.Asn304Ser Single submitter ⚠
p.Asn87Lys Single submitter ⚠
p.Asp151Ala Single submitter ⚠
p.Asp151Gly Single submitter ⚠
p.Asp163Glu Single submitter ⚠
p.Asp225Glu Single submitter ⚠
p.Asp261Gly Single submitter ⚠
p.Asp277Glu Single submitter ⚠
p.Cys45Tyr Single submitter ⚠
p.Gln264Arg Single submitter ⚠
p.Gln70Glu Single submitter ⚠
p.Glu222Asp Single submitter ⚠
p.Glu312Gly Single submitter ⚠
p.Gly200Glu Single submitter ⚠
p.Gly228Ala Single submitter ⚠
p.Ile14Val Single submitter ⚠
p.Ile174Asn Single submitter ⚠
p.Ile198Leu Single submitter ⚠
p.Leu288His Single submitter ⚠
p.Leu2Val Single submitter ⚠
p.Leu40Phe Single submitter ⚠
p.Lys192Gln Single submitter ⚠
p.Lys290Arg Single submitter ⚠
p.Lys31Asn Single submitter ⚠
p.Lys333Arg Single submitter ⚠
p.Lys41Arg Single submitter ⚠
p.Lys89Arg Single submitter ⚠
p.Phe152Leu Single submitter ⚠
p.Phe161Ile Single submitter ⚠
p.Phe271Ile Single submitter ⚠
p.Ser100Ile Single submitter ⚠
p.Ser64Asn Single submitter ⚠
p.Ser93Leu Single submitter ⚠
p.Thr121Ser Single submitter ⚠
p.Thr273Ile Single submitter ⚠
p.Thr321Asn Single submitter ⚠
p.Thr321Ser Single submitter ⚠
p.Trp188Arg Single submitter ⚠
p.Trp74Cys Single submitter ⚠
p.Tyr185Cys Single submitter ⚠
p.Tyr265Cys Single submitter ⚠
p.Val17Met Single submitter ⚠
p.Val335Leu Single submitter ⚠
p.Val81Met Single submitter ⚠