ANGPTL8 — 3 ClinVar variants
All ClinVar germline ANGPTL8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 3 flagged for review →
3 Uncertain significance
Full ANGPTL8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 3
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 1
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All ANGPTL8 variants
Uncertain significance 3
- p.Ala122Pro Single submitter ⚠
- p.Arg72His Single submitter ⚠
- p.Thr55Ile Single submitter ⚠