ANHX — 67 ClinVar variants
All ClinVar germline ANHX variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
1 Benign · 7 Likely benign · 59 Uncertain significance
Full ANHX gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANHX p.Ala155Thr Uncertain significance Single submitter
- ANHX p.Ala16Val Uncertain significance Single submitter
- ANHX p.Ala212Gly Uncertain significance Single submitter
- ANHX p.Ala212Val Uncertain significance Single submitter
- ANHX p.Ala463Pro Uncertain significance Single submitter
- ANHX p.Arg189Trp Uncertain significance Single submitter
- ANHX p.Arg213Lys Uncertain significance Single submitter
- ANHX p.Arg242Gly Uncertain significance Single submitter
- ANHX p.Arg242His Uncertain significance Single submitter
- ANHX p.Arg52His Uncertain significance Single submitter
- ANHX p.Asp270Val Uncertain significance Single submitter
- ANHX p.Asp460Tyr Uncertain significance Single submitter
- ANHX p.Asp70Glu Uncertain significance Single submitter
- ANHX p.Gln388Pro Uncertain significance Single submitter
- ANHX p.Gln50Arg Uncertain significance Single submitter
- ANHX p.Gly440Cys Uncertain significance Single submitter
- ANHX p.Gly440Ser Uncertain significance Single submitter
- ANHX p.Gly440Val Uncertain significance Single submitter
- ANHX p.His54Pro Uncertain significance Single submitter
- ANHX p.Leu138Met Uncertain significance Single submitter
- ANHX p.Leu424Phe Uncertain significance Single submitter
- ANHX p.Leu424Val Uncertain significance Single submitter
- ANHX p.Met199Val Uncertain significance Single submitter
- ANHX p.Pro117Leu Uncertain significance Single submitter
- ANHX p.Pro129Ala Uncertain significance Single submitter
- ANHX p.Pro226Leu Uncertain significance Single submitter
- ANHX p.Pro265Leu Uncertain significance Single submitter
- ANHX p.Pro435Leu Uncertain significance Single submitter
- ANHX p.Pro439Leu Uncertain significance Single submitter
- ANHX p.Ser389Arg Uncertain significance Single submitter
- ANHX p.Thr253Ala Uncertain significance Single submitter
- ANHX p.Val118Ala Uncertain significance Single submitter
- ANHX p.Val279Leu Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- ANHX p.Ser230Cys Benign Multiple submitters
- ANHX p.Ala19Val Uncertain significance Single submitter
- ANHX p.Ala25Gly Uncertain significance Single submitter
- ANHX p.Ala59Thr Uncertain significance Single submitter
- ANHX p.Ala66Thr Uncertain significance Single submitter
- ANHX p.Arg104His Likely benign Single submitter
- ANHX p.Arg191His Uncertain significance Single submitter
- ANHX p.Arg242Cys Uncertain significance Single submitter
- ANHX p.Arg30Gln Uncertain significance Single submitter
- ANHX p.Arg67Cys Uncertain significance Single submitter
- ANHX p.Asn99Ser Uncertain significance Single submitter
- ANHX p.Asp48Tyr Uncertain significance Single submitter
- ANHX p.Asp60Gly Uncertain significance Single submitter
- ANHX p.Asp60Tyr Uncertain significance Single submitter
- ANHX p.Cys79Gly Uncertain significance Single submitter
- ANHX p.Gln180Glu Uncertain significance Single submitter
- ANHX p.Gln418Lys Uncertain significance Single submitter
- ANHX p.Glu179Lys Uncertain significance Single submitter
- ANHX p.Leu474Pro Uncertain significance Single submitter
- ANHX p.Pro41Leu Uncertain significance Single submitter
- ANHX p.Pro439Arg Uncertain significance Single submitter
- ANHX p.Ser140Asn Uncertain significance Single submitter
- ANHX p.Ser459Cys Uncertain significance Single submitter
- ANHX p.Thr174Met Uncertain significance Single submitter
- ANHX p.Thr6Ile Uncertain significance Single submitter
- ANHX p.Val112Met Uncertain significance Single submitter
- ANHX p.Val118Leu Uncertain significance Single submitter
- ANHX p.Val390Met Likely benign Single submitter
- ANHX p.Val95Leu Uncertain significance Single submitter
All ANHX variants
Benign 1
- p.Ser230Cys Multiple submitters ⚠
Likely benign 7
- p.Ala64Val Single submitter
- p.Arg104His Single submitter ⚠
- p.Arg227His Single submitter
- p.Arg406Gln Single submitter
- p.Asn159Ser Single submitter
- p.Ser384= Single submitter
- p.Val390Met Single submitter ⚠
Uncertain significance 59
- p.Ala155Thr Single submitter ⚠
- p.Ala16Val Single submitter ⚠
- p.Ala19Val Single submitter ⚠
- p.Ala212Gly Single submitter ⚠
- p.Ala212Val Single submitter ⚠
- p.Ala25Gly Single submitter ⚠
- p.Ala463Pro Single submitter ⚠
- p.Ala59Thr Single submitter ⚠
- p.Ala66Thr Single submitter ⚠
- p.Arg189Trp Single submitter ⚠
- p.Arg191His Single submitter ⚠
- p.Arg213Lys Single submitter ⚠
- p.Arg242Cys Single submitter ⚠
- p.Arg242Gly Single submitter ⚠
- p.Arg242His Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg52His Single submitter ⚠
- p.Arg67Cys Single submitter ⚠
- p.Asn99Ser Single submitter ⚠
- p.Asp270Val Single submitter ⚠
- p.Asp460Tyr Single submitter ⚠
- p.Asp48Tyr Single submitter ⚠
- p.Asp60Gly Single submitter ⚠
- p.Asp60Tyr Single submitter ⚠
- p.Asp70Glu Single submitter ⚠
- p.Cys79Gly Single submitter ⚠
- p.Gln180Glu Single submitter ⚠
- p.Gln388Pro Single submitter ⚠
- p.Gln418Lys Single submitter ⚠
- p.Gln50Arg Single submitter ⚠
- p.Glu179Lys Single submitter ⚠
- p.Gly440Cys Single submitter ⚠
- p.Gly440Ser Single submitter ⚠
- p.Gly440Val Single submitter ⚠
- p.His54Pro Single submitter ⚠
- p.Leu138Met Single submitter ⚠
- p.Leu424Phe Single submitter ⚠
- p.Leu424Val Single submitter ⚠
- p.Leu474Pro Single submitter ⚠
- p.Met199Val Single submitter ⚠
- p.Pro117Leu Single submitter ⚠
- p.Pro129Ala Single submitter ⚠
- p.Pro226Leu Single submitter ⚠
- p.Pro265Leu Single submitter ⚠
- p.Pro41Leu Single submitter ⚠
- p.Pro435Leu Single submitter ⚠
- p.Pro439Arg Single submitter ⚠
- p.Pro439Leu Single submitter ⚠
- p.Ser140Asn Single submitter ⚠
- p.Ser389Arg Single submitter ⚠
- p.Ser459Cys Single submitter ⚠
- p.Thr174Met Single submitter ⚠
- p.Thr253Ala Single submitter ⚠
- p.Thr6Ile Single submitter ⚠
- p.Val112Met Single submitter ⚠
- p.Val118Ala Single submitter ⚠
- p.Val118Leu Single submitter ⚠
- p.Val279Leu Single submitter ⚠
- p.Val95Leu Single submitter ⚠