ANKAR — 197 ClinVar variants
All ClinVar germline ANKAR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 176 flagged for review →
11 Benign · 13 Likely benign · 173 Uncertain significance
Full ANKAR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 176
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 99
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKAR p.Ala1192Thr Uncertain significance Single submitter
- ANKAR p.Ala1319Glu Uncertain significance Single submitter
- ANKAR p.Ala1385Val Uncertain significance Single submitter
- ANKAR p.Ala1427Asp Uncertain significance Single submitter
- ANKAR p.Ala580Ser Uncertain significance Single submitter
- ANKAR p.Ala580Thr Uncertain significance Single submitter
- ANKAR p.Ala83Val Uncertain significance Single submitter
- ANKAR p.Ala908Val Uncertain significance Single submitter
- ANKAR p.Arg1159His Uncertain significance Single submitter
- ANKAR p.Arg1357Gln Uncertain significance Single submitter
- ANKAR p.Arg408Gln Uncertain significance Single submitter
- ANKAR p.Arg545Gly Uncertain significance Single submitter
- ANKAR p.Arg62His Uncertain significance Single submitter
- ANKAR p.Arg716Gln Uncertain significance Single submitter
- ANKAR p.Arg894Pro Uncertain significance Single submitter
- ANKAR p.Asn242Lys Uncertain significance Single submitter
- ANKAR p.Asn465Ser Uncertain significance Single submitter
- ANKAR p.Asn527Ser Uncertain significance Single submitter
- ANKAR p.Asn749Ser Uncertain significance Single submitter
- ANKAR p.Asn76Ser Uncertain significance Single submitter
- ANKAR p.Asp192Glu Uncertain significance Single submitter
- ANKAR p.Asp278Tyr Uncertain significance Single submitter
- ANKAR p.Asp60Asn Uncertain significance Single submitter
- ANKAR p.Asp653Asn Uncertain significance Single submitter
- ANKAR p.Cys1109Arg Uncertain significance Single submitter
- ANKAR p.Cys1296Gly Uncertain significance Single submitter
- ANKAR p.Cys591Tyr Uncertain significance Single submitter
- ANKAR p.Gln14Arg Uncertain significance Single submitter
- ANKAR p.Gln255Arg Uncertain significance Single submitter
- ANKAR p.Gln290Glu Uncertain significance Single submitter
- ANKAR p.Gln376Lys Uncertain significance Single submitter
- ANKAR p.Gln968His Uncertain significance Single submitter
- ANKAR p.Glu1177Lys Uncertain significance Single submitter
- ANKAR p.Glu394Lys Uncertain significance Single submitter
- ANKAR p.Glu712Ala Uncertain significance Single submitter
- ANKAR p.Glu855Val Uncertain significance Single submitter
- ANKAR p.Gly144Arg Uncertain significance Single submitter
- ANKAR p.Gly533Val Uncertain significance Single submitter
- ANKAR p.Gly603Val Uncertain significance Single submitter
- ANKAR p.Gly918Glu Uncertain significance Single submitter
- ANKAR p.Gly992Glu Uncertain significance Single submitter
- ANKAR p.His1122Tyr Uncertain significance Single submitter
- ANKAR p.His1423Tyr Uncertain significance Single submitter
- ANKAR p.His575Tyr Uncertain significance Single submitter
- ANKAR p.His684Leu Uncertain significance Single submitter
- ANKAR p.Ile1173Met Uncertain significance Single submitter
- ANKAR p.Ile1208Val Uncertain significance Single submitter
- ANKAR p.Ile1346Arg Uncertain significance Single submitter
- ANKAR p.Ile193Thr Uncertain significance Single submitter
- ANKAR p.Ile193Val Uncertain significance Single submitter
- ANKAR p.Ile360Thr Uncertain significance Single submitter
- ANKAR p.Ile836Thr Uncertain significance Single submitter
- ANKAR p.Leu1038Phe Uncertain significance Single submitter
- ANKAR p.Leu1180Arg Uncertain significance Single submitter
- ANKAR p.Leu1218Ser Uncertain significance Single submitter
- ANKAR p.Leu1338Val Uncertain significance Single submitter
- ANKAR p.Leu552Gln Uncertain significance Single submitter
- ANKAR p.Leu590Pro Uncertain significance Single submitter
- ANKAR p.Leu622Pro Uncertain significance Single submitter
- ANKAR p.Leu681Ile Uncertain significance Single submitter
- ANKAR p.Leu870Ile Uncertain significance Single submitter
- ANKAR p.Leu94Pro Uncertain significance Single submitter
- ANKAR p.Lys1363Glu Uncertain significance Single submitter
- ANKAR p.Lys305Asn Uncertain significance Single submitter
- ANKAR p.Lys331Arg Uncertain significance Single submitter
- ANKAR p.Lys865Gln Uncertain significance Single submitter
- ANKAR p.Met1380Thr Uncertain significance Single submitter
- ANKAR p.Met430Leu Uncertain significance Single submitter
- ANKAR p.Met430Thr Uncertain significance Single submitter
- ANKAR p.Met493Ile Uncertain significance Single submitter
- ANKAR p.Met722Val Uncertain significance Single submitter
- ANKAR p.Met844Val Uncertain significance Single submitter
- ANKAR p.Phe1383Leu Uncertain significance Single submitter
- ANKAR p.Pro1072Ala Uncertain significance Single submitter
- ANKAR p.Pro1097Ser Uncertain significance Single submitter
- ANKAR p.Pro10Arg Uncertain significance Single submitter
- ANKAR p.Pro1431Leu Uncertain significance Single submitter
- ANKAR p.Pro187Leu Uncertain significance Single submitter
- ANKAR p.Pro391Ser Uncertain significance Single submitter
- ANKAR p.Pro606Leu Uncertain significance Single submitter
- ANKAR p.Pro606Ser Uncertain significance Single submitter
- ANKAR p.Ser1315Gly Uncertain significance Single submitter
- ANKAR p.Ser1399Leu Uncertain significance Single submitter
- ANKAR p.Ser250Gly Uncertain significance Single submitter
- ANKAR p.Ser41Arg Uncertain significance Single submitter
- ANKAR p.Ser599Phe Uncertain significance Single submitter
- ANKAR p.Ser660Pro Uncertain significance Single submitter
- ANKAR p.Thr1403Ile Uncertain significance Single submitter
- ANKAR p.Thr20Ile Uncertain significance Single submitter
- ANKAR p.Thr525Ala Uncertain significance Single submitter
- ANKAR p.Thr635Ile Uncertain significance Single submitter
- ANKAR p.Tyr441Asn Uncertain significance Single submitter
- ANKAR p.Tyr808Cys Uncertain significance Single submitter
- ANKAR p.Val1111Ile Uncertain significance Single submitter
- ANKAR p.Val1271Ile Uncertain significance Single submitter
- ANKAR p.Val1376Leu Uncertain significance Single submitter
- ANKAR p.Val559Ile Uncertain significance Single submitter
- ANKAR p.Val78Ala Uncertain significance Single submitter
- ANKAR p.Val818Ala Uncertain significance Single submitter
Predictors split 77
The independent predictors disagree with each other — read with care.
- ANKAR p.Val776Ala Likely benign Multiple submitters
- ANKAR p.Ala1288Val Uncertain significance Single submitter
- ANKAR p.Ala505Thr Uncertain significance Single submitter
- ANKAR p.Ala775Glu Uncertain significance Single submitter
- ANKAR p.Ala782Thr Uncertain significance Single submitter
- ANKAR p.Ala930Val Uncertain significance Single submitter
- ANKAR p.Ala970Thr Uncertain significance Single submitter
- ANKAR p.Arg1043Thr Uncertain significance Single submitter
- ANKAR p.Arg1272His Likely benign Single submitter
- ANKAR p.Arg1290Cys Uncertain significance Single submitter
- ANKAR p.Arg29Gly Uncertain significance Single submitter
- ANKAR p.Arg519Cys Uncertain significance Single submitter
- ANKAR p.Arg563His Uncertain significance Single submitter
- ANKAR p.Arg848Trp Uncertain significance Single submitter
- ANKAR p.Arg872Ile Uncertain significance Single submitter
- ANKAR p.Arg894Leu Uncertain significance Single submitter
- ANKAR p.Asn1071Ser Uncertain significance Single submitter
- ANKAR p.Asn1157Ser Uncertain significance Single submitter
- ANKAR p.Asn403Tyr Uncertain significance Single submitter
- ANKAR p.Asn674His Uncertain significance Single submitter
- ANKAR p.Asn857Thr Uncertain significance Single submitter
- ANKAR p.Asn896Ser Uncertain significance Single submitter
- ANKAR p.Asp1142Val Uncertain significance Single submitter
- ANKAR p.Cys367Ser Uncertain significance Single submitter
- ANKAR p.Cys728Phe Uncertain significance Single submitter
- ANKAR p.Cys846Tyr Uncertain significance Single submitter
- ANKAR p.Gln1008His Uncertain significance Single submitter
- ANKAR p.Glu106Ala Uncertain significance Single submitter
- ANKAR p.Glu1140Gly Uncertain significance Single submitter
- ANKAR p.Glu1185Lys Uncertain significance Single submitter
- ANKAR p.Glu221Gly Uncertain significance Single submitter
- ANKAR p.Glu417Ala Uncertain significance Single submitter
- ANKAR p.Glu507Gly Uncertain significance Single submitter
- ANKAR p.Glu707Ala Uncertain significance Single submitter
- ANKAR p.Glu989Gln Uncertain significance Single submitter
- ANKAR p.Gly501Ser Uncertain significance Single submitter
- ANKAR p.Gly672Arg Uncertain significance Single submitter
- ANKAR p.Gly866Val Uncertain significance Single submitter
- ANKAR p.His101Arg Uncertain significance Single submitter
- ANKAR p.His159Arg Uncertain significance Single submitter
- ANKAR p.His159Leu Uncertain significance Single submitter
- ANKAR p.His379Leu Uncertain significance Single submitter
- ANKAR p.His937Leu Uncertain significance Single submitter
- ANKAR p.Ile1062Met Uncertain significance Single submitter
- ANKAR p.Ile1064Thr Uncertain significance Single submitter
- ANKAR p.Ile1143Asn Uncertain significance Single submitter
- ANKAR p.Ile1202Leu Uncertain significance Single submitter
- ANKAR p.Ile1316Met Uncertain significance Single submitter
- ANKAR p.Ile146Met Uncertain significance Single submitter
- ANKAR p.Ile427Thr Uncertain significance Single submitter
- ANKAR p.Ile607Val Uncertain significance Single submitter
- ANKAR p.Ile909Ser Uncertain significance Single submitter
- ANKAR p.Leu1338Pro Uncertain significance Single submitter
- ANKAR p.Leu341Arg Uncertain significance Single submitter
- ANKAR p.Leu629Phe Uncertain significance Single submitter
- ANKAR p.Leu832Trp Uncertain significance Single submitter
- ANKAR p.Lys959Glu Uncertain significance Single submitter
- ANKAR p.Met708Ile Uncertain significance Single submitter
- ANKAR p.Met999Thr Uncertain significance Single submitter
- ANKAR p.Phe1396Leu Uncertain significance Single submitter
- ANKAR p.Phe249Leu Uncertain significance Single submitter
- ANKAR p.Phe321Ser Uncertain significance Single submitter
- ANKAR p.Phe945Leu Uncertain significance Single submitter
- ANKAR p.Pro324Leu Uncertain significance Single submitter
- ANKAR p.Pro573Ser Uncertain significance Single submitter
- ANKAR p.Pro627Arg Uncertain significance Single submitter
- ANKAR p.Ser1019Asn Uncertain significance Single submitter
- ANKAR p.Ser1054Asn Uncertain significance Single submitter
- ANKAR p.Ser518Arg Uncertain significance Single submitter
- ANKAR p.Thr1046Met Uncertain significance Single submitter
- ANKAR p.Thr535Pro Uncertain significance Single submitter
- ANKAR p.Thr597Met Uncertain significance Single submitter
- ANKAR p.Trp456Ser Uncertain significance Single submitter
- ANKAR p.Tyr438Ser Benign Single submitter
- ANKAR p.Val1086Gly Uncertain significance Single submitter
- ANKAR p.Val721Ile Uncertain significance Single submitter
- ANKAR p.Val89Met Uncertain significance Single submitter
All ANKAR variants
Benign 11
- p.Asn938= Multiple submitters
- p.Gln1419Leu Multiple submitters
- p.Ile1349= Multiple submitters
- p.Leu94Arg Multiple submitters
- p.Thr206Ala Multiple submitters
- p.Thr92= Multiple submitters
- p.Tyr1262Ser Multiple submitters
- c.1307+5G>A Single submitter
- p.Leu779= Single submitter
- p.Thr682Ala Single submitter
- p.Tyr438Ser Single submitter ⚠
Likely benign 13
- p.Val776Ala Multiple submitters ⚠
- p.Ala610= Single submitter
- p.Arg1272His Single submitter ⚠
- p.Arg491Lys Single submitter
- p.Asn1418Ser Single submitter
- p.Asp308Glu Single submitter
- p.Glu36Ter Single submitter
- p.His433Arg Single submitter
- p.His539Leu Single submitter
- p.Leu1373= Single submitter
- p.Leu444= Single submitter
- p.Tyr275Cys Single submitter
- p.Val616Ile Single submitter
Uncertain significance 173
- p.Ala1192Thr Single submitter ⚠
- p.Ala1288Val Single submitter ⚠
- p.Ala1319Glu Single submitter ⚠
- p.Ala1385Val Single submitter ⚠
- p.Ala1427Asp Single submitter ⚠
- p.Ala505Thr Single submitter ⚠
- p.Ala580Ser Single submitter ⚠
- p.Ala580Thr Single submitter ⚠
- p.Ala775Glu Single submitter ⚠
- p.Ala782Thr Single submitter ⚠
- p.Ala83Val Single submitter ⚠
- p.Ala908Val Single submitter ⚠
- p.Ala930Val Single submitter ⚠
- p.Ala970Thr Single submitter ⚠
- p.Arg1043Thr Single submitter ⚠
- p.Arg1159His Single submitter ⚠
- p.Arg1290Cys Single submitter ⚠
- p.Arg1357Gln Single submitter ⚠
- p.Arg29Gly Single submitter ⚠
- p.Arg408Gln Single submitter ⚠
- p.Arg519Cys Single submitter ⚠
- p.Arg545Gly Single submitter ⚠
- p.Arg563His Single submitter ⚠
- p.Arg62His Single submitter ⚠
- p.Arg716Gln Single submitter ⚠
- p.Arg848Trp Single submitter ⚠
- p.Arg872Ile Single submitter ⚠
- p.Arg894Leu Single submitter ⚠
- p.Arg894Pro Single submitter ⚠
- p.Asn1071Ser Single submitter ⚠
- p.Asn1157Ser Single submitter ⚠
- p.Asn242Lys Single submitter ⚠
- p.Asn403Tyr Single submitter ⚠
- p.Asn465Ser Single submitter ⚠
- p.Asn527Ser Single submitter ⚠
- p.Asn674His Single submitter ⚠
- p.Asn749Ser Single submitter ⚠
- p.Asn76Ser Single submitter ⚠
- p.Asn857Thr Single submitter ⚠
- p.Asn896Ser Single submitter ⚠
- p.Asp1142Val Single submitter ⚠
- p.Asp192Glu Single submitter ⚠
- p.Asp278Tyr Single submitter ⚠
- p.Asp60Asn Single submitter ⚠
- p.Asp653Asn Single submitter ⚠
- p.Cys1109Arg Single submitter ⚠
- p.Cys1296Gly Single submitter ⚠
- p.Cys367Ser Single submitter ⚠
- p.Cys591Tyr Single submitter ⚠
- p.Cys728Phe Single submitter ⚠
- p.Cys846Tyr Single submitter ⚠
- p.Gln1008His Single submitter ⚠
- p.Gln14Arg Single submitter ⚠
- p.Gln255Arg Single submitter ⚠
- p.Gln290Glu Single submitter ⚠
- p.Gln376Lys Single submitter ⚠
- p.Gln968His Single submitter ⚠
- p.Glu106Ala Single submitter ⚠
- p.Glu1140Gly Single submitter ⚠
- p.Glu1177Lys Single submitter ⚠
- p.Glu1185Lys Single submitter ⚠
- p.Glu221Gly Single submitter ⚠
- p.Glu394Lys Single submitter ⚠
- p.Glu417Ala Single submitter ⚠
- p.Glu507Gly Single submitter ⚠
- p.Glu707Ala Single submitter ⚠
- p.Glu712Ala Single submitter ⚠
- p.Glu855Val Single submitter ⚠
- p.Glu989Gln Single submitter ⚠
- p.Gly144Arg Single submitter ⚠
- p.Gly501Ser Single submitter ⚠
- p.Gly533Val Single submitter ⚠
- p.Gly603Val Single submitter ⚠
- p.Gly672Arg Single submitter ⚠
- p.Gly866Val Single submitter ⚠
- p.Gly918Glu Single submitter ⚠
- p.Gly992Glu Single submitter ⚠
- p.His101Arg Single submitter ⚠
- p.His1122Tyr Single submitter ⚠
- p.His1423Tyr Single submitter ⚠
- p.His159Arg Single submitter ⚠
- p.His159Leu Single submitter ⚠
- p.His379Leu Single submitter ⚠
- p.His575Tyr Single submitter ⚠
- p.His684Leu Single submitter ⚠
- p.His937Leu Single submitter ⚠
- p.Ile1062Met Single submitter ⚠
- p.Ile1064Thr Single submitter ⚠
- p.Ile1143Asn Single submitter ⚠
- p.Ile1173Met Single submitter ⚠
- p.Ile1202Leu Single submitter ⚠
- p.Ile1208Val Single submitter ⚠
- p.Ile1316Met Single submitter ⚠
- p.Ile1346Arg Single submitter ⚠
- p.Ile146Met Single submitter ⚠
- p.Ile193Thr Single submitter ⚠
- p.Ile193Val Single submitter ⚠
- p.Ile360Thr Single submitter ⚠
- p.Ile427Thr Single submitter ⚠
- p.Ile607Val Single submitter ⚠
- p.Ile836Thr Single submitter ⚠
- p.Ile909Ser Single submitter ⚠
- p.Leu1038Phe Single submitter ⚠
- p.Leu1180Arg Single submitter ⚠
- p.Leu1218Ser Single submitter ⚠
- p.Leu1338Pro Single submitter ⚠
- p.Leu1338Val Single submitter ⚠
- p.Leu341Arg Single submitter ⚠
- p.Leu552Gln Single submitter ⚠
- p.Leu590Pro Single submitter ⚠
- p.Leu622Pro Single submitter ⚠
- p.Leu629Phe Single submitter ⚠
- p.Leu681Ile Single submitter ⚠
- p.Leu832Trp Single submitter ⚠
- p.Leu870Ile Single submitter ⚠
- p.Leu94Pro Single submitter ⚠
- p.Lys1363Glu Single submitter ⚠
- p.Lys305Asn Single submitter ⚠
- p.Lys331Arg Single submitter ⚠
- p.Lys865Gln Single submitter ⚠
- p.Lys959Glu Single submitter ⚠
- p.Met1380Thr Single submitter ⚠
- p.Met430Leu Single submitter ⚠
- p.Met430Thr Single submitter ⚠
- p.Met493Ile Single submitter ⚠
- p.Met708Ile Single submitter ⚠
- p.Met722Val Single submitter ⚠
- p.Met844Val Single submitter ⚠
- p.Met999Thr Single submitter ⚠
- p.Phe1383Leu Single submitter ⚠
- p.Phe1396Leu Single submitter ⚠
- p.Phe249Leu Single submitter ⚠
- p.Phe321Ser Single submitter ⚠
- p.Phe945Leu Single submitter ⚠
- p.Pro1072Ala Single submitter ⚠
- p.Pro1097Ser Single submitter ⚠
- p.Pro10Arg Single submitter ⚠
- p.Pro1431Leu Single submitter ⚠
- p.Pro187Leu Single submitter ⚠
- p.Pro324Leu Single submitter ⚠
- p.Pro391Ser Single submitter ⚠
- p.Pro573Ser Single submitter ⚠
- p.Pro606Leu Single submitter ⚠
- p.Pro606Ser Single submitter ⚠
- p.Pro627Arg Single submitter ⚠
- p.Ser1019Asn Single submitter ⚠
- p.Ser1054Asn Single submitter ⚠
- p.Ser1315Gly Single submitter ⚠
- p.Ser1399Leu Single submitter ⚠
- p.Ser250Gly Single submitter ⚠
- p.Ser41Arg Single submitter ⚠
- p.Ser518Arg Single submitter ⚠
- p.Ser599Phe Single submitter ⚠
- p.Ser660Pro Single submitter ⚠
- p.Thr1046Met Single submitter ⚠
- p.Thr1403Ile Single submitter ⚠
- p.Thr20Ile Single submitter ⚠
- p.Thr525Ala Single submitter ⚠
- p.Thr535Pro Single submitter ⚠
- p.Thr597Met Single submitter ⚠
- p.Thr635Ile Single submitter ⚠
- p.Trp456Ser Single submitter ⚠
- p.Tyr441Asn Single submitter ⚠
- p.Tyr808Cys Single submitter ⚠
- p.Val1086Gly Single submitter ⚠
- p.Val1111Ile Single submitter ⚠
- p.Val1271Ile Single submitter ⚠
- p.Val1376Leu Single submitter ⚠
- p.Val559Ile Single submitter ⚠
- p.Val721Ile Single submitter ⚠
- p.Val78Ala Single submitter ⚠
- p.Val818Ala Single submitter ⚠
- p.Val89Met Single submitter ⚠