ANKFN1 — 98 ClinVar variants
All ClinVar germline ANKFN1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 82 flagged for review →
2 Likely benign · 96 Uncertain significance
Full ANKFN1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 82
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 71
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKFN1 c.2260+19C>T Uncertain significance Single submitter
- ANKFN1 c.-73A>G Uncertain significance Single submitter
- ANKFN1 c.-88G>C Uncertain significance Single submitter
- ANKFN1 p.Ala24Thr Uncertain significance Single submitter
- ANKFN1 p.Ala267Val Uncertain significance Single submitter
- ANKFN1 p.Ala361Glu Uncertain significance Single submitter
- ANKFN1 p.Ala361Thr Uncertain significance Single submitter
- ANKFN1 p.Ala86Val Uncertain significance Single submitter
- ANKFN1 p.Arg122Trp Uncertain significance Single submitter
- ANKFN1 p.Arg22Ser Uncertain significance Single submitter
- ANKFN1 p.Arg377Ser Uncertain significance Single submitter
- ANKFN1 p.Arg393Gln Uncertain significance Single submitter
- ANKFN1 p.Arg412His Uncertain significance Single submitter
- ANKFN1 p.Arg5Lys Uncertain significance Single submitter
- ANKFN1 p.Arg603His Uncertain significance Single submitter
- ANKFN1 p.Arg640Cys Uncertain significance Single submitter
- ANKFN1 p.Arg95His Uncertain significance Single submitter
- ANKFN1 p.Asn135Asp Uncertain significance Single submitter
- ANKFN1 p.Asn295Asp Uncertain significance Single submitter
- ANKFN1 p.Asn323Asp Uncertain significance Single submitter
- ANKFN1 p.Asp163Gly Uncertain significance Single submitter
- ANKFN1 p.Asp237Glu Uncertain significance Single submitter
- ANKFN1 p.Cys275Ser Uncertain significance Single submitter
- ANKFN1 p.Gln397Glu Uncertain significance Single submitter
- ANKFN1 p.Gln48Lys Uncertain significance Single submitter
- ANKFN1 p.Gln80Arg Uncertain significance Single submitter
- ANKFN1 p.Glu220Gly Uncertain significance Single submitter
- ANKFN1 p.Glu232Ala Uncertain significance Single submitter
- ANKFN1 p.Glu240Lys Uncertain significance Single submitter
- ANKFN1 p.Glu310Gln Uncertain significance Single submitter
- ANKFN1 p.Gly20Arg Uncertain significance Single submitter
- ANKFN1 p.His32Pro Uncertain significance Single submitter
- ANKFN1 p.His398Arg Uncertain significance Single submitter
- ANKFN1 p.His77Gln Uncertain significance Single submitter
- ANKFN1 p.His84Tyr Uncertain significance Single submitter
- ANKFN1 p.Ile18Met Uncertain significance Single submitter
- ANKFN1 p.Ile443Val Uncertain significance Single submitter
- ANKFN1 p.Ile588Met Uncertain significance Single submitter
- ANKFN1 p.Ile590Met Uncertain significance Single submitter
- ANKFN1 p.Ile590Thr Uncertain significance Single submitter
- ANKFN1 p.Ile693Val Uncertain significance Single submitter
- ANKFN1 p.Leu125Phe Uncertain significance Single submitter
- ANKFN1 p.Leu610Met Uncertain significance Single submitter
- ANKFN1 p.Leu695Val Uncertain significance Single submitter
- ANKFN1 p.Leu76Ile Uncertain significance Single submitter
- ANKFN1 p.Lys17Arg Uncertain significance Single submitter
- ANKFN1 p.Met321Ile Uncertain significance Single submitter
- ANKFN1 p.Met682Thr Uncertain significance Single submitter
- ANKFN1 p.Met711Ile Uncertain significance Single submitter
- ANKFN1 p.Met711Val Uncertain significance Single submitter
- ANKFN1 p.Met750Val Uncertain significance Single submitter
- ANKFN1 p.Phe424Ser Uncertain significance Single submitter
- ANKFN1 p.Ser206Gly Uncertain significance Single submitter
- ANKFN1 p.Ser293Ile Uncertain significance Single submitter
- ANKFN1 p.Ser31Asn Uncertain significance Single submitter
- ANKFN1 p.Ser469Cys Uncertain significance Single submitter
- ANKFN1 p.Ser664Gly Uncertain significance Single submitter
- ANKFN1 p.Thr120Ala Uncertain significance Single submitter
- ANKFN1 p.Thr213Ala Uncertain significance Single submitter
- ANKFN1 p.Thr326Ile Uncertain significance Single submitter
- ANKFN1 p.Thr358Met Uncertain significance Single submitter
- ANKFN1 p.Thr479Met Uncertain significance Single submitter
- ANKFN1 p.Thr503Ile Uncertain significance Single submitter
- ANKFN1 p.Thr524Ile Uncertain significance Single submitter
- ANKFN1 p.Thr52Asn Uncertain significance Single submitter
- ANKFN1 p.Tyr302Cys Uncertain significance Single submitter
- ANKFN1 p.Tyr399Cys Uncertain significance Single submitter
- ANKFN1 p.Val294Ile Uncertain significance Single submitter
- ANKFN1 p.Val298Ile Uncertain significance Single submitter
- ANKFN1 p.Val342Ile Uncertain significance Single submitter
- ANKFN1 p.Val342Phe Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- ANKFN1 p.Ala93Val Uncertain significance Single submitter
- ANKFN1 p.Arg412Ser Uncertain significance Single submitter
- ANKFN1 p.Arg95Cys Uncertain significance Single submitter
- ANKFN1 p.Glu102Ala Uncertain significance Single submitter
- ANKFN1 p.Leu104Val Uncertain significance Single submitter
- ANKFN1 p.Met138Thr Uncertain significance Single submitter
- ANKFN1 p.Met73Thr Uncertain significance Single submitter
- ANKFN1 p.Ser110Tyr Uncertain significance Single submitter
- ANKFN1 p.Ser85Arg Uncertain significance Single submitter
- ANKFN1 p.Tyr252Cys Uncertain significance Single submitter
- ANKFN1 p.Val637Glu Uncertain significance Single submitter
All ANKFN1 variants
Likely benign 2
- p.Ile495Val Single submitter
- p.Thr781Asn Single submitter
Uncertain significance 96
- c.2260+19C>T Single submitter ⚠
- c.-73A>G Single submitter ⚠
- c.-88G>C Single submitter ⚠
- p.Ala24Thr Single submitter ⚠
- p.Ala267Val Single submitter ⚠
- p.Ala346Ser Single submitter
- p.Ala361Glu Single submitter ⚠
- p.Ala361Thr Single submitter ⚠
- p.Ala86Val Single submitter ⚠
- p.Ala93Val Single submitter ⚠
- p.Arg122Trp Single submitter ⚠
- p.Arg221Ser Single submitter
- p.Arg22Ser Single submitter ⚠
- p.Arg257Leu Single submitter
- p.Arg377Ser Single submitter ⚠
- p.Arg393Gln Single submitter ⚠
- p.Arg412Cys Single submitter
- p.Arg412His Single submitter ⚠
- p.Arg412Ser Single submitter ⚠
- p.Arg5Lys Single submitter ⚠
- p.Arg603His Single submitter ⚠
- p.Arg640Cys Single submitter ⚠
- p.Arg95Cys Single submitter ⚠
- p.Arg95His Single submitter ⚠
- p.Asn135Asp Single submitter ⚠
- p.Asn295Asp Single submitter ⚠
- p.Asn323Asp Single submitter ⚠
- p.Asp121Tyr Single submitter
- p.Asp163Glu Single submitter
- p.Asp163Gly Single submitter ⚠
- p.Asp176Asn Single submitter
- p.Asp237Glu Single submitter ⚠
- p.Cys275Ser Single submitter ⚠
- p.Gln397Glu Single submitter ⚠
- p.Gln48Lys Single submitter ⚠
- p.Gln80Arg Single submitter ⚠
- p.Glu102Ala Single submitter ⚠
- p.Glu220Gly Single submitter ⚠
- p.Glu232Ala Single submitter ⚠
- p.Glu240Lys Single submitter ⚠
- p.Glu310Gln Single submitter ⚠
- p.Gly20Arg Single submitter ⚠
- p.Gly437Arg Single submitter
- p.His32Pro Single submitter ⚠
- p.His398Arg Single submitter ⚠
- p.His77Gln Single submitter ⚠
- p.His84Tyr Single submitter ⚠
- p.Ile18Met Single submitter ⚠
- p.Ile443Val Single submitter ⚠
- p.Ile588Met Single submitter ⚠
- p.Ile590Met Single submitter ⚠
- p.Ile590Thr Single submitter ⚠
- p.Ile693Val Single submitter ⚠
- p.Leu104Val Single submitter ⚠
- p.Leu125Phe Single submitter ⚠
- p.Leu608Phe Single submitter
- p.Leu610Met Single submitter ⚠
- p.Leu695Val Single submitter ⚠
- p.Leu76Ile Single submitter ⚠
- p.Lys17Arg Single submitter ⚠
- p.Lys510Gln Single submitter
- p.Met138Thr Single submitter ⚠
- p.Met321Ile Single submitter ⚠
- p.Met682Thr Single submitter ⚠
- p.Met711Ile Single submitter ⚠
- p.Met711Val Single submitter ⚠
- p.Met73Thr Single submitter ⚠
- p.Met750Val Single submitter ⚠
- p.Phe424Ser Single submitter ⚠
- p.Pro360Leu Single submitter
- p.Ser110Tyr Single submitter ⚠
- p.Ser206Gly Single submitter ⚠
- p.Ser293Ile Single submitter ⚠
- p.Ser31Asn Single submitter ⚠
- p.Ser419Asn Single submitter
- p.Ser469Cys Single submitter ⚠
- p.Ser618Cys Single submitter
- p.Ser664Gly Single submitter ⚠
- p.Ser85Arg Single submitter ⚠
- p.Thr120Ala Single submitter ⚠
- p.Thr213Ala Single submitter ⚠
- p.Thr326Ile Single submitter ⚠
- p.Thr358Met Single submitter ⚠
- p.Thr479Met Single submitter ⚠
- p.Thr503Ile Single submitter ⚠
- p.Thr524Ile Single submitter ⚠
- p.Thr52Asn Single submitter ⚠
- p.Tyr252Cys Single submitter ⚠
- p.Tyr302Cys Single submitter ⚠
- p.Tyr399Cys Single submitter ⚠
- p.Tyr612Cys Single submitter
- p.Val294Ile Single submitter ⚠
- p.Val298Ile Single submitter ⚠
- p.Val342Ile Single submitter ⚠
- p.Val342Phe Single submitter ⚠
- p.Val637Glu Single submitter ⚠