ANKMY1 — 179 ClinVar variants
All ClinVar germline ANKMY1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 157 flagged for review →
4 Benign · 21 Likely benign · 154 Uncertain significance
Full ANKMY1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 157
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 102
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKMY1 p.Ala1014Gly Uncertain significance Single submitter
- ANKMY1 p.Ala281Ser Uncertain significance Single submitter
- ANKMY1 p.Ala340Val Uncertain significance Single submitter
- ANKMY1 p.Ala356Val Uncertain significance Single submitter
- ANKMY1 p.Ala380Thr Uncertain significance Single submitter
- ANKMY1 p.Ala429Thr Uncertain significance Single submitter
- ANKMY1 p.Ala579Ser Uncertain significance Single submitter
- ANKMY1 p.Ala702Thr Uncertain significance Single submitter
- ANKMY1 p.Ala741Val Uncertain significance Single submitter
- ANKMY1 p.Arg282His Uncertain significance Single submitter
- ANKMY1 p.Arg483Lys Uncertain significance Single submitter
- ANKMY1 p.Arg493Cys Uncertain significance Single submitter
- ANKMY1 p.Arg882Gln Uncertain significance Single submitter
- ANKMY1 p.Arg915Gln Uncertain significance Single submitter
- ANKMY1 p.Arg974Cys Uncertain significance Single submitter
- ANKMY1 p.Arg974Pro Uncertain significance Single submitter
- ANKMY1 p.Arg979His Uncertain significance Single submitter
- ANKMY1 p.Asn252Ser Uncertain significance Single submitter
- ANKMY1 p.Asn327Lys Uncertain significance Single submitter
- ANKMY1 p.Asn435Ser Uncertain significance Single submitter
- ANKMY1 p.Asn544Ser Uncertain significance Single submitter
- ANKMY1 p.Asp238Val Uncertain significance Single submitter
- ANKMY1 p.Asp294Val Uncertain significance Single submitter
- ANKMY1 p.Asp598Asn Uncertain significance Single submitter
- ANKMY1 p.Asp699Asn Uncertain significance Single submitter
- ANKMY1 p.Asp872Tyr Uncertain significance Single submitter
- ANKMY1 p.Cys509Arg Uncertain significance Single submitter
- ANKMY1 p.Cys823Tyr Uncertain significance Single submitter
- ANKMY1 p.Gln1018Lys Uncertain significance Single submitter
- ANKMY1 p.Gln237Arg Uncertain significance Single submitter
- ANKMY1 p.Gln311Pro Uncertain significance Single submitter
- ANKMY1 p.Gln313Lys Uncertain significance Single submitter
- ANKMY1 p.Gln733Glu Uncertain significance Single submitter
- ANKMY1 p.Glu174Lys Uncertain significance Single submitter
- ANKMY1 p.Glu293Lys Uncertain significance Single submitter
- ANKMY1 p.Glu346Gly Uncertain significance Single submitter
- ANKMY1 p.Glu414Lys Uncertain significance Single submitter
- ANKMY1 p.Glu691Lys Uncertain significance Single submitter
- ANKMY1 p.Glu745Asp Uncertain significance Single submitter
- ANKMY1 p.Glu756Lys Uncertain significance Single submitter
- ANKMY1 p.Glu937Lys Uncertain significance Single submitter
- ANKMY1 p.Gly1010Arg Uncertain significance Single submitter
- ANKMY1 p.Gly116Arg Uncertain significance Single submitter
- ANKMY1 p.Gly172Asp Uncertain significance Single submitter
- ANKMY1 p.Gly329Ser Uncertain significance Single submitter
- ANKMY1 p.Gly510Arg Uncertain significance Single submitter
- ANKMY1 p.Gly537Arg Uncertain significance Single submitter
- ANKMY1 p.Gly543Arg Uncertain significance Single submitter
- ANKMY1 p.Gly686Arg Uncertain significance Single submitter
- ANKMY1 p.Gly714Val Uncertain significance Single submitter
- ANKMY1 p.Gly746Ala Uncertain significance Single submitter
- ANKMY1 p.Gly747Asp Uncertain significance Single submitter
- ANKMY1 p.Gly784Asp Uncertain significance Single submitter
- ANKMY1 p.Gly96Val Uncertain significance Single submitter
- ANKMY1 p.His268Tyr Uncertain significance Single submitter
- ANKMY1 p.His394Arg Uncertain significance Single submitter
- ANKMY1 p.His502Tyr Uncertain significance Single submitter
- ANKMY1 p.His533Leu Uncertain significance Single submitter
- ANKMY1 p.Ile792Thr Uncertain significance Single submitter
- ANKMY1 p.Leu194Val Uncertain significance Single submitter
- ANKMY1 p.Leu249Met Uncertain significance Single submitter
- ANKMY1 p.Leu279Pro Uncertain significance Single submitter
- ANKMY1 p.Leu306Phe Uncertain significance Single submitter
- ANKMY1 p.Leu465Val Uncertain significance Single submitter
- ANKMY1 p.Leu719Val Uncertain significance Single submitter
- ANKMY1 p.Leu771Phe Uncertain significance Single submitter
- ANKMY1 p.Leu828Pro Uncertain significance Single submitter
- ANKMY1 p.Met130Arg Uncertain significance Single submitter
- ANKMY1 p.Met328Val Uncertain significance Single submitter
- ANKMY1 p.Met609Val Uncertain significance Single submitter
- ANKMY1 p.Phe275Leu Uncertain significance Single submitter
- ANKMY1 p.Pro257Leu Uncertain significance Single submitter
- ANKMY1 p.Pro289Leu Uncertain significance Single submitter
- ANKMY1 p.Pro344Leu Uncertain significance Single submitter
- ANKMY1 p.Pro444Ser Uncertain significance Single submitter
- ANKMY1 p.Pro525Ala Uncertain significance Single submitter
- ANKMY1 p.Pro592Ser Uncertain significance Single submitter
- ANKMY1 p.Pro667Gln Uncertain significance Single submitter
- ANKMY1 p.Pro743Leu Uncertain significance Single submitter
- ANKMY1 p.Pro787Leu Uncertain significance Single submitter
- ANKMY1 p.Pro810Arg Uncertain significance Single submitter
- ANKMY1 p.Pro984Leu Uncertain significance Single submitter
- ANKMY1 p.Ser431Phe Uncertain significance Single submitter
- ANKMY1 p.Ser583Thr Uncertain significance Single submitter
- ANKMY1 p.Ser589Leu Uncertain significance Single submitter
- ANKMY1 p.Ser726Arg Uncertain significance Single submitter
- ANKMY1 p.Thr196Ala Uncertain significance Single submitter
- ANKMY1 p.Thr324Ala Uncertain significance Single submitter
- ANKMY1 p.Thr545Ala Uncertain significance Single submitter
- ANKMY1 p.Thr555Met Uncertain significance Single submitter
- ANKMY1 p.Thr671Ile Uncertain significance Single submitter
- ANKMY1 p.Thr815Ala Uncertain significance Single submitter
- ANKMY1 p.Thr899Met Uncertain significance Single submitter
- ANKMY1 p.Thr928Arg Uncertain significance Single submitter
- ANKMY1 p.Thr928Ser Uncertain significance Single submitter
- ANKMY1 p.Trp131Cys Uncertain significance Single submitter
- ANKMY1 p.Tyr873Asp Uncertain significance Single submitter
- ANKMY1 p.Val1013Leu Uncertain significance Single submitter
- ANKMY1 p.Val292Ile Uncertain significance Single submitter
- ANKMY1 p.Val474Leu Uncertain significance Single submitter
- ANKMY1 p.Val634Met Uncertain significance Single submitter
- ANKMY1 p.Val651Leu Uncertain significance Single submitter
Predictors split 55
The independent predictors disagree with each other — read with care.
- ANKMY1 p.Ala165Val Uncertain significance Single submitter
- ANKMY1 p.Ala734Pro Uncertain significance Single submitter
- ANKMY1 p.Arg146Gln Uncertain significance Single submitter
- ANKMY1 p.Arg157Gln Uncertain significance Single submitter
- ANKMY1 p.Arg603Trp Uncertain significance Single submitter
- ANKMY1 p.Arg624Cys Uncertain significance Single submitter
- ANKMY1 p.Arg769Gln Likely benign Single submitter
- ANKMY1 p.Arg897Cys Uncertain significance Single submitter
- ANKMY1 p.Arg903Gln Uncertain significance Single submitter
- ANKMY1 p.Arg905Trp Uncertain significance Single submitter
- ANKMY1 p.Arg979Cys Uncertain significance Single submitter
- ANKMY1 p.Arg985Cys Uncertain significance Single submitter
- ANKMY1 p.Asp182Asn Uncertain significance Single submitter
- ANKMY1 p.Asp760Gly Uncertain significance Single submitter
- ANKMY1 p.Asp852Asn Uncertain significance Single submitter
- ANKMY1 p.Glu209Gly Uncertain significance Single submitter
- ANKMY1 p.Glu438Val Uncertain significance Single submitter
- ANKMY1 p.Glu611Lys Uncertain significance Single submitter
- ANKMY1 p.Glu908Gln Uncertain significance Single submitter
- ANKMY1 p.Gly338Cys Uncertain significance Single submitter
- ANKMY1 p.Gly646Ala Uncertain significance Single submitter
- ANKMY1 p.Gly658Arg Uncertain significance Single submitter
- ANKMY1 p.Gly746Trp Uncertain significance Single submitter
- ANKMY1 p.Gly775Arg Likely benign Single submitter
- ANKMY1 p.Gly850Arg Uncertain significance Single submitter
- ANKMY1 p.Gly988Arg Uncertain significance Single submitter
- ANKMY1 p.His122Gln Uncertain significance Single submitter
- ANKMY1 p.Ile397Ser Uncertain significance Single submitter
- ANKMY1 p.Ile689Leu Uncertain significance Single submitter
- ANKMY1 p.Leu424Ile Uncertain significance Single submitter
- ANKMY1 p.Met152Val Uncertain significance Single submitter
- ANKMY1 p.Met893Ile Uncertain significance Single submitter
- ANKMY1 p.Phe106Leu Uncertain significance Single submitter
- ANKMY1 p.Phe299Leu Uncertain significance Single submitter
- ANKMY1 p.Pro305Arg Uncertain significance Single submitter
- ANKMY1 p.Pro666Thr Uncertain significance Single submitter
- ANKMY1 p.Pro674Leu Uncertain significance Single submitter
- ANKMY1 p.Ser459Leu Uncertain significance Single submitter
- ANKMY1 p.Ser530Arg Uncertain significance Single submitter
- ANKMY1 p.Ser571Leu Uncertain significance Single submitter
- ANKMY1 p.Thr110Ile Uncertain significance Single submitter
- ANKMY1 p.Thr138Met Uncertain significance Single submitter
- ANKMY1 p.Thr140Ile Uncertain significance Single submitter
- ANKMY1 p.Thr417Met Uncertain significance Single submitter
- ANKMY1 p.Tyr103Cys Uncertain significance Single submitter
- ANKMY1 p.Tyr735Cys Uncertain significance Single submitter
- ANKMY1 p.Tyr873Cys Uncertain significance Single submitter
- ANKMY1 p.Tyr970Cys Uncertain significance Single submitter
- ANKMY1 p.Val1022Ile Uncertain significance Single submitter
- ANKMY1 p.Val183Met Uncertain significance Single submitter
- ANKMY1 p.Val385Leu Uncertain significance Single submitter
- ANKMY1 p.Val648Met Uncertain significance Single submitter
- ANKMY1 p.Val687Leu Uncertain significance Single submitter
- ANKMY1 p.Val768Ala Uncertain significance Single submitter
-
ANKMY1 p.Pro488Gln
Likely benign
No assertion criteria
EBV-positive nodal T- and NK-cell lymphoma
All ANKMY1 variants
Benign 4
- p.Ala219= Multiple submitters
- p.Ser212Thr Multiple submitters
- p.Ala851= Single submitter
- p.Arg493= Single submitter
Likely benign 21
- p.His268Asn Multiple submitters
- p.Ala936Val Single submitter
- p.Arg617Gln Single submitter
- p.Arg769Gln Single submitter ⚠
- p.Arg883Lys Single submitter
- p.Asn265Asp Single submitter
- p.Asp565Asn Single submitter
- p.Cys1009= Single submitter
- p.Gln92Arg Single submitter
- p.Gly201Ser Single submitter
- p.Gly775Arg Single submitter ⚠
- p.Lys839Arg Single submitter
- p.Met259Thr Single submitter
- p.Met836Val Single submitter
- p.Pro341Leu Single submitter
- p.Thr229Met Single submitter
- p.Thr417= Single submitter
- p.Val1013Met Single submitter
- p.Val494Ile Single submitter
- p.Val799Ile Single submitter
- p.Pro488Gln No assertion criteria EBV-positive nodal T- and NK-cell lymphoma ⚠
Uncertain significance 154
- p.Ala1014Gly Single submitter ⚠
- p.Ala165Val Single submitter ⚠
- p.Ala281Ser Single submitter ⚠
- p.Ala340Val Single submitter ⚠
- p.Ala356Val Single submitter ⚠
- p.Ala380Thr Single submitter ⚠
- p.Ala429Thr Single submitter ⚠
- p.Ala579Ser Single submitter ⚠
- p.Ala702Thr Single submitter ⚠
- p.Ala734Pro Single submitter ⚠
- p.Ala741Val Single submitter ⚠
- p.Arg146Gln Single submitter ⚠
- p.Arg157Gln Single submitter ⚠
- p.Arg282His Single submitter ⚠
- p.Arg483Lys Single submitter ⚠
- p.Arg493Cys Single submitter ⚠
- p.Arg603Trp Single submitter ⚠
- p.Arg624Cys Single submitter ⚠
- p.Arg882Gln Single submitter ⚠
- p.Arg897Cys Single submitter ⚠
- p.Arg903Gln Single submitter ⚠
- p.Arg905Trp Single submitter ⚠
- p.Arg915Gln Single submitter ⚠
- p.Arg974Cys Single submitter ⚠
- p.Arg974Pro Single submitter ⚠
- p.Arg979Cys Single submitter ⚠
- p.Arg979His Single submitter ⚠
- p.Arg985Cys Single submitter ⚠
- p.Asn252Ser Single submitter ⚠
- p.Asn327Lys Single submitter ⚠
- p.Asn435Ser Single submitter ⚠
- p.Asn544Ser Single submitter ⚠
- p.Asp182Asn Single submitter ⚠
- p.Asp238Val Single submitter ⚠
- p.Asp294Val Single submitter ⚠
- p.Asp598Asn Single submitter ⚠
- p.Asp699Asn Single submitter ⚠
- p.Asp760Gly Single submitter ⚠
- p.Asp852Asn Single submitter ⚠
- p.Asp872Tyr Single submitter ⚠
- p.Cys509Arg Single submitter ⚠
- p.Cys823Tyr Single submitter ⚠
- p.Gln1018Lys Single submitter ⚠
- p.Gln237Arg Single submitter ⚠
- p.Gln311Pro Single submitter ⚠
- p.Gln313Lys Single submitter ⚠
- p.Gln733Glu Single submitter ⚠
- p.Glu174Lys Single submitter ⚠
- p.Glu209Gly Single submitter ⚠
- p.Glu293Lys Single submitter ⚠
- p.Glu346Gly Single submitter ⚠
- p.Glu414Lys Single submitter ⚠
- p.Glu438Val Single submitter ⚠
- p.Glu611Lys Single submitter ⚠
- p.Glu691Lys Single submitter ⚠
- p.Glu745Asp Single submitter ⚠
- p.Glu756Lys Single submitter ⚠
- p.Glu908Gln Single submitter ⚠
- p.Glu937Lys Single submitter ⚠
- p.Gly1010Arg Single submitter ⚠
- p.Gly116Arg Single submitter ⚠
- p.Gly172Asp Single submitter ⚠
- p.Gly329Ser Single submitter ⚠
- p.Gly338Cys Single submitter ⚠
- p.Gly510Arg Single submitter ⚠
- p.Gly537Arg Single submitter ⚠
- p.Gly543Arg Single submitter ⚠
- p.Gly646Ala Single submitter ⚠
- p.Gly658Arg Single submitter ⚠
- p.Gly686Arg Single submitter ⚠
- p.Gly714Val Single submitter ⚠
- p.Gly746Ala Single submitter ⚠
- p.Gly746Trp Single submitter ⚠
- p.Gly747Asp Single submitter ⚠
- p.Gly784Asp Single submitter ⚠
- p.Gly850Arg Single submitter ⚠
- p.Gly96Val Single submitter ⚠
- p.Gly988Arg Single submitter ⚠
- p.His122Gln Single submitter ⚠
- p.His268Tyr Single submitter ⚠
- p.His394Arg Single submitter ⚠
- p.His502Tyr Single submitter ⚠
- p.His533Leu Single submitter ⚠
- p.Ile397Ser Single submitter ⚠
- p.Ile689Leu Single submitter ⚠
- p.Ile792Thr Single submitter ⚠
- p.Leu194Val Single submitter ⚠
- p.Leu249Met Single submitter ⚠
- p.Leu279Pro Single submitter ⚠
- p.Leu306Phe Single submitter ⚠
- p.Leu424Ile Single submitter ⚠
- p.Leu465Val Single submitter ⚠
- p.Leu719Val Single submitter ⚠
- p.Leu771Phe Single submitter ⚠
- p.Leu828Pro Single submitter ⚠
- p.Met130Arg Single submitter ⚠
- p.Met152Val Single submitter ⚠
- p.Met328Val Single submitter ⚠
- p.Met609Val Single submitter ⚠
- p.Met893Ile Single submitter ⚠
- p.Phe106Leu Single submitter ⚠
- p.Phe275Leu Single submitter ⚠
- p.Phe299Leu Single submitter ⚠
- p.Pro257Leu Single submitter ⚠
- p.Pro289Leu Single submitter ⚠
- p.Pro305Arg Single submitter ⚠
- p.Pro344Leu Single submitter ⚠
- p.Pro444Ser Single submitter ⚠
- p.Pro525Ala Single submitter ⚠
- p.Pro592Ser Single submitter ⚠
- p.Pro666Thr Single submitter ⚠
- p.Pro667Gln Single submitter ⚠
- p.Pro674Leu Single submitter ⚠
- p.Pro743Leu Single submitter ⚠
- p.Pro787Leu Single submitter ⚠
- p.Pro810Arg Single submitter ⚠
- p.Pro984Leu Single submitter ⚠
- p.Ser431Phe Single submitter ⚠
- p.Ser459Leu Single submitter ⚠
- p.Ser530Arg Single submitter ⚠
- p.Ser571Leu Single submitter ⚠
- p.Ser583Thr Single submitter ⚠
- p.Ser589Leu Single submitter ⚠
- p.Ser726Arg Single submitter ⚠
- p.Thr110Ile Single submitter ⚠
- p.Thr138Met Single submitter ⚠
- p.Thr140Ile Single submitter ⚠
- p.Thr196Ala Single submitter ⚠
- p.Thr324Ala Single submitter ⚠
- p.Thr417Met Single submitter ⚠
- p.Thr545Ala Single submitter ⚠
- p.Thr555Met Single submitter ⚠
- p.Thr671Ile Single submitter ⚠
- p.Thr815Ala Single submitter ⚠
- p.Thr899Met Single submitter ⚠
- p.Thr928Arg Single submitter ⚠
- p.Thr928Ser Single submitter ⚠
- p.Trp131Cys Single submitter ⚠
- p.Tyr103Cys Single submitter ⚠
- p.Tyr735Cys Single submitter ⚠
- p.Tyr873Asp Single submitter ⚠
- p.Tyr873Cys Single submitter ⚠
- p.Tyr970Cys Single submitter ⚠
- p.Val1013Leu Single submitter ⚠
- p.Val1022Ile Single submitter ⚠
- p.Val183Met Single submitter ⚠
- p.Val292Ile Single submitter ⚠
- p.Val385Leu Single submitter ⚠
- p.Val474Leu Single submitter ⚠
- p.Val634Met Single submitter ⚠
- p.Val648Met Single submitter ⚠
- p.Val651Leu Single submitter ⚠
- p.Val687Leu Single submitter ⚠
- p.Val768Ala Single submitter ⚠