ANKMY2 — 68 ClinVar variants
All ClinVar germline ANKMY2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
68 Uncertain significance
Full ANKMY2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKMY2 p.Ala161Val Uncertain significance Single submitter
- ANKMY2 p.Ala279Ser Uncertain significance Single submitter
- ANKMY2 p.Ala300Val Uncertain significance Single submitter
- ANKMY2 p.Arg254Gly Uncertain significance Single submitter
- ANKMY2 p.Asn110His Uncertain significance Single submitter
- ANKMY2 p.Asp316Tyr Uncertain significance Single submitter
- ANKMY2 p.Asp71Gly Uncertain significance Single submitter
- ANKMY2 p.Cys128Phe Uncertain significance Single submitter
- ANKMY2 p.Cys227Ser Uncertain significance Single submitter
- ANKMY2 p.Cys41Tyr Uncertain significance Single submitter
- ANKMY2 p.Gln211Pro Uncertain significance Single submitter
- ANKMY2 p.Gln26Arg Uncertain significance Single submitter
- ANKMY2 p.Gln395Pro Uncertain significance Single submitter
- ANKMY2 p.Gln437Arg Uncertain significance Single submitter
- ANKMY2 p.Glu105Ala Uncertain significance Single submitter
- ANKMY2 p.Glu397Gly Uncertain significance Single submitter
- ANKMY2 p.Glu414Gly Uncertain significance Single submitter
- ANKMY2 p.Glu423Lys Uncertain significance Single submitter
- ANKMY2 p.Gly29Glu Uncertain significance Single submitter
- ANKMY2 p.Gly69Arg Uncertain significance Single submitter
- ANKMY2 p.His126Arg Uncertain significance Single submitter
- ANKMY2 p.His223Leu Uncertain significance Single submitter
- ANKMY2 p.His381Leu Uncertain significance Single submitter
- ANKMY2 p.His79Arg Uncertain significance Single submitter
- ANKMY2 p.Ile131Val Uncertain significance Single submitter
- ANKMY2 p.Ile178Met Uncertain significance Single submitter
- ANKMY2 p.Ile308Val Uncertain significance Single submitter
- ANKMY2 p.Ile339Thr Uncertain significance Single submitter
- ANKMY2 p.Ile363Val Uncertain significance Single submitter
- ANKMY2 p.Ile4Met Uncertain significance Single submitter
- ANKMY2 p.Leu369Val Uncertain significance Single submitter
- ANKMY2 p.Met214Thr Uncertain significance Single submitter
- ANKMY2 p.Met51Ile Uncertain significance Single submitter
- ANKMY2 p.Met51Val Uncertain significance Single submitter
- ANKMY2 p.Met99Ile Uncertain significance Single submitter
- ANKMY2 p.Pro157Ser Uncertain significance Single submitter
- ANKMY2 p.Ser111Tyr Uncertain significance Single submitter
- ANKMY2 p.Ser296Ala Uncertain significance Single submitter
- ANKMY2 p.Ser90Cys Uncertain significance Single submitter
- ANKMY2 p.Thr169Asn Uncertain significance Single submitter
- ANKMY2 p.Thr169Ile Uncertain significance Single submitter
- ANKMY2 p.Thr30Ala Uncertain significance Single submitter
- ANKMY2 p.Tyr364Ser Uncertain significance Single submitter
- ANKMY2 p.Val303Ile Uncertain significance Single submitter
- ANKMY2 p.Val37Ala Uncertain significance Single submitter
- ANKMY2 p.Val391Ile Uncertain significance Single submitter
- ANKMY2 p.Val98Ile Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- ANKMY2 p.Asn134Ser Uncertain significance Single submitter
- ANKMY2 p.Cys205Gly Uncertain significance Single submitter
- ANKMY2 p.Gln118Glu Uncertain significance Single submitter
- ANKMY2 p.Glu101Gly Uncertain significance Single submitter
- ANKMY2 p.Glu293Lys Uncertain significance Single submitter
- ANKMY2 p.Ile132Val Uncertain significance Single submitter
- ANKMY2 p.Ile228Met Uncertain significance Single submitter
- ANKMY2 p.Ile95Met Uncertain significance Single submitter
- ANKMY2 p.Leu384Phe Uncertain significance Single submitter
- ANKMY2 p.Leu50Val Uncertain significance Single submitter
- ANKMY2 p.Leu59Arg Uncertain significance Single submitter
- ANKMY2 p.Lys366Glu Uncertain significance Single submitter
- ANKMY2 p.Lys375Glu Uncertain significance Single submitter
- ANKMY2 p.Lys6Ile Uncertain significance Single submitter
- ANKMY2 p.Met214Ile Uncertain significance Single submitter
- ANKMY2 p.Pro158Arg Uncertain significance Single submitter
- ANKMY2 p.Thr171Met Uncertain significance Single submitter
- ANKMY2 p.Val179Met Uncertain significance Single submitter
- ANKMY2 p.Val19Leu Uncertain significance Single submitter
- ANKMY2 p.Val72Ala Uncertain significance Single submitter
-
ANKMY2 p.His68Leu
Uncertain significance
No assertion criteria
High myopia
All ANKMY2 variants
Uncertain significance 68
- p.Ala161Val Single submitter ⚠
- p.Ala279Ser Single submitter ⚠
- p.Ala300Val Single submitter ⚠
- p.Arg254Gly Single submitter ⚠
- p.Asn110His Single submitter ⚠
- p.Asn134Ser Single submitter ⚠
- p.Asp316Tyr Single submitter ⚠
- p.Asp71Gly Single submitter ⚠
- p.Cys128Phe Single submitter ⚠
- p.Cys205Gly Single submitter ⚠
- p.Cys227Ser Single submitter ⚠
- p.Cys41Tyr Single submitter ⚠
- p.Gln118Glu Single submitter ⚠
- p.Gln211Pro Single submitter ⚠
- p.Gln26Arg Single submitter ⚠
- p.Gln395Pro Single submitter ⚠
- p.Gln437Arg Single submitter ⚠
- p.Glu101Gly Single submitter ⚠
- p.Glu105Ala Single submitter ⚠
- p.Glu293Lys Single submitter ⚠
- p.Glu397Gly Single submitter ⚠
- p.Glu414Gly Single submitter ⚠
- p.Glu423Lys Single submitter ⚠
- p.Gly29Glu Single submitter ⚠
- p.Gly69Arg Single submitter ⚠
- p.His126Arg Single submitter ⚠
- p.His223Leu Single submitter ⚠
- p.His381Leu Single submitter ⚠
- p.His79Arg Single submitter ⚠
- p.Ile131Val Single submitter ⚠
- p.Ile132Val Single submitter ⚠
- p.Ile178Met Single submitter ⚠
- p.Ile228Met Single submitter ⚠
- p.Ile308Val Single submitter ⚠
- p.Ile339Thr Single submitter ⚠
- p.Ile363Val Single submitter ⚠
- p.Ile4Met Single submitter ⚠
- p.Ile95Met Single submitter ⚠
- p.Leu369Val Single submitter ⚠
- p.Leu384Phe Single submitter ⚠
- p.Leu50Val Single submitter ⚠
- p.Leu59Arg Single submitter ⚠
- p.Lys366Glu Single submitter ⚠
- p.Lys375Glu Single submitter ⚠
- p.Lys6Ile Single submitter ⚠
- p.Met214Ile Single submitter ⚠
- p.Met214Thr Single submitter ⚠
- p.Met51Ile Single submitter ⚠
- p.Met51Val Single submitter ⚠
- p.Met99Ile Single submitter ⚠
- p.Pro157Ser Single submitter ⚠
- p.Pro158Arg Single submitter ⚠
- p.Ser111Tyr Single submitter ⚠
- p.Ser296Ala Single submitter ⚠
- p.Ser90Cys Single submitter ⚠
- p.Thr169Asn Single submitter ⚠
- p.Thr169Ile Single submitter ⚠
- p.Thr171Met Single submitter ⚠
- p.Thr30Ala Single submitter ⚠
- p.Tyr364Ser Single submitter ⚠
- p.Val179Met Single submitter ⚠
- p.Val19Leu Single submitter ⚠
- p.Val303Ile Single submitter ⚠
- p.Val37Ala Single submitter ⚠
- p.Val391Ile Single submitter ⚠
- p.Val72Ala Single submitter ⚠
- p.Val98Ile Single submitter ⚠
- p.His68Leu No assertion criteria High myopia ⚠