ANKRA2 — 36 ClinVar variants
All ClinVar germline ANKRA2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
36 Uncertain significance
Full ANKRA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRA2 p.Ala49Thr Uncertain significance Single submitter
- ANKRA2 p.Asn58Asp Uncertain significance Single submitter
- ANKRA2 p.Gln46Arg Uncertain significance Single submitter
- ANKRA2 p.Glu140Asp Uncertain significance Single submitter
- ANKRA2 p.Glu199Gln Uncertain significance Single submitter
- ANKRA2 p.Gly160Glu Uncertain significance Single submitter
- ANKRA2 p.Gly26Asp Uncertain significance Single submitter
- ANKRA2 p.His102Arg Uncertain significance Single submitter
- ANKRA2 p.Ile32Thr Uncertain significance Single submitter
- ANKRA2 p.Ile9Val Uncertain significance Single submitter
- ANKRA2 p.Lys70Arg Uncertain significance Single submitter
- ANKRA2 p.Lys70Gln Uncertain significance Single submitter
- ANKRA2 p.Pro107Leu Uncertain significance Single submitter
- ANKRA2 p.Pro208His Uncertain significance Single submitter
- ANKRA2 p.Pro251His Uncertain significance Single submitter
- ANKRA2 p.Ser104Pro Uncertain significance Single submitter
- ANKRA2 p.Ser104Thr Uncertain significance Single submitter
- ANKRA2 p.Ser118Thr Uncertain significance Single submitter
- ANKRA2 p.Ser20Arg Uncertain significance Single submitter
- ANKRA2 p.Ser302Leu Uncertain significance Single submitter
- ANKRA2 p.Ser4Leu Uncertain significance Single submitter
- ANKRA2 p.Thr143Ala Uncertain significance Single submitter
- ANKRA2 p.Val239Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- ANKRA2 p.Cys99Trp Uncertain significance Single submitter
- ANKRA2 p.Gln297Leu Uncertain significance Single submitter
- ANKRA2 p.Gly214Val Uncertain significance Single submitter
- ANKRA2 p.His113Arg Uncertain significance Single submitter
- ANKRA2 p.Leu56Ser Uncertain significance Single submitter
- ANKRA2 p.Met162Ile Uncertain significance Single submitter
- ANKRA2 p.Pro117Arg Uncertain significance Single submitter
- ANKRA2 p.Pro251Ser Uncertain significance Single submitter
- ANKRA2 p.Ser220Leu Uncertain significance Single submitter
- ANKRA2 p.Val111Leu Uncertain significance Single submitter
All ANKRA2 variants
Uncertain significance 36
- p.Ala49Thr Single submitter ⚠
- p.Asn58Asp Single submitter ⚠
- p.Cys237Phe Single submitter
- p.Cys99Trp Single submitter ⚠
- p.Gln297Leu Single submitter ⚠
- p.Gln46Arg Single submitter ⚠
- p.Glu140Asp Single submitter ⚠
- p.Glu199Gln Single submitter ⚠
- p.Gly160Glu Single submitter ⚠
- p.Gly214Val Single submitter ⚠
- p.Gly26Asp Single submitter ⚠
- p.His102Arg Single submitter ⚠
- p.His113Arg Single submitter ⚠
- p.Ile32Thr Single submitter ⚠
- p.Ile9Val Single submitter ⚠
- p.Leu56Ser Single submitter ⚠
- p.Lys70Arg Single submitter ⚠
- p.Lys70Gln Single submitter ⚠
- p.Met162Ile Single submitter ⚠
- p.Met285Val Single submitter
- p.Pro107Leu Single submitter ⚠
- p.Pro117Arg Single submitter ⚠
- p.Pro208His Single submitter ⚠
- p.Pro208Thr Single submitter
- p.Pro251His Single submitter ⚠
- p.Pro251Ser Single submitter ⚠
- p.Ser104Pro Single submitter ⚠
- p.Ser104Thr Single submitter ⚠
- p.Ser118Thr Single submitter ⚠
- p.Ser20Arg Single submitter ⚠
- p.Ser220Leu Single submitter ⚠
- p.Ser302Leu Single submitter ⚠
- p.Ser4Leu Single submitter ⚠
- p.Thr143Ala Single submitter ⚠
- p.Val111Leu Single submitter ⚠
- p.Val239Ile Single submitter ⚠