ANKRD10 — 50 ClinVar variants
All ClinVar germline ANKRD10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
5 Likely benign · 45 Uncertain significance
Full ANKRD10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD10 p.Ala237Val Uncertain significance Single submitter
- ANKRD10 p.Ala359Thr Uncertain significance Single submitter
- ANKRD10 p.Ala99Val Uncertain significance Single submitter
- ANKRD10 p.Asn186Lys Uncertain significance Single submitter
- ANKRD10 p.Gln106Arg Uncertain significance Single submitter
- ANKRD10 p.Gln113Glu Uncertain significance Single submitter
- ANKRD10 p.Gln171Arg Uncertain significance Single submitter
- ANKRD10 p.Gln199Glu Uncertain significance Single submitter
- ANKRD10 p.Glu124Lys Uncertain significance Single submitter
- ANKRD10 p.Glu395Lys Uncertain significance Single submitter
- ANKRD10 p.Gly196Arg Uncertain significance Single submitter
- ANKRD10 p.Gly346Ser Uncertain significance Single submitter
- ANKRD10 p.Gly412Cys Uncertain significance Single submitter
- ANKRD10 p.Gly5Ala Uncertain significance Single submitter
- ANKRD10 p.His150Arg Uncertain significance Single submitter
- ANKRD10 p.His198Tyr Uncertain significance Single submitter
- ANKRD10 p.His376Tyr Uncertain significance Single submitter
- ANKRD10 p.Ile112Asn Uncertain significance Single submitter
- ANKRD10 p.Ile129Val Uncertain significance Single submitter
- ANKRD10 p.Leu177Phe Uncertain significance Single submitter
- ANKRD10 p.Leu274Met Uncertain significance Single submitter
- ANKRD10 p.Leu50Val Uncertain significance Single submitter
- ANKRD10 p.Lys251Arg Uncertain significance Single submitter
- ANKRD10 p.Phe319Leu Uncertain significance Single submitter
- ANKRD10 p.Pro121Leu Uncertain significance Single submitter
- ANKRD10 p.Pro291Leu Uncertain significance Single submitter
- ANKRD10 p.Ser207Gly Uncertain significance Single submitter
- ANKRD10 p.Ser219Pro Uncertain significance Single submitter
- ANKRD10 p.Ser21Leu Uncertain significance Single submitter
- ANKRD10 p.Ser269Phe Uncertain significance Single submitter
- ANKRD10 p.Ser2Trp Uncertain significance Single submitter
- ANKRD10 p.Ser392Gly Uncertain significance Single submitter
- ANKRD10 p.Ser399Pro Uncertain significance Single submitter
- ANKRD10 p.Val254Ile Uncertain significance Single submitter
- ANKRD10 p.Val270Ile Uncertain significance Single submitter
- ANKRD10 p.Val400Leu Uncertain significance Single submitter
- ANKRD10 p.Val86Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- ANKRD10 p.Gly282Ala Uncertain significance Single submitter
- ANKRD10 p.Ile164Thr Uncertain significance Single submitter
- ANKRD10 p.Lys70Met Uncertain significance Single submitter
- ANKRD10 p.Phe14Leu Uncertain significance Single submitter
- ANKRD10 p.Phe286Leu Uncertain significance Single submitter
- ANKRD10 p.Phe380Ser Uncertain significance Single submitter
- ANKRD10 p.Val62Ala Uncertain significance Single submitter
All ANKRD10 variants
Likely benign 5
- p.Asn117Ser Single submitter
- p.Asn85Asp Single submitter
- p.His187Arg Single submitter
- p.Ser293Asn Single submitter
- p.Val238Met Single submitter
Uncertain significance 45
- p.Ala237Val Single submitter ⚠
- p.Ala359Thr Single submitter ⚠
- p.Ala99Val Single submitter ⚠
- p.Asn186Lys Single submitter ⚠
- p.Gln106Arg Single submitter ⚠
- p.Gln113Glu Single submitter ⚠
- p.Gln171Arg Single submitter ⚠
- p.Gln199Glu Single submitter ⚠
- p.Glu124Lys Single submitter ⚠
- p.Glu395Lys Single submitter ⚠
- p.Gly169Ser Single submitter
- p.Gly196Arg Single submitter ⚠
- p.Gly282Ala Single submitter ⚠
- p.Gly346Ser Single submitter ⚠
- p.Gly412Cys Single submitter ⚠
- p.Gly5Ala Single submitter ⚠
- p.His150Arg Single submitter ⚠
- p.His198Tyr Single submitter ⚠
- p.His376Tyr Single submitter ⚠
- p.Ile112Asn Single submitter ⚠
- p.Ile129Val Single submitter ⚠
- p.Ile164Thr Single submitter ⚠
- p.Leu177Phe Single submitter ⚠
- p.Leu274Met Single submitter ⚠
- p.Leu50Val Single submitter ⚠
- p.Lys251Arg Single submitter ⚠
- p.Lys70Met Single submitter ⚠
- p.Phe14Leu Single submitter ⚠
- p.Phe286Leu Single submitter ⚠
- p.Phe319Leu Single submitter ⚠
- p.Phe380Ser Single submitter ⚠
- p.Pro121Leu Single submitter ⚠
- p.Pro291Leu Single submitter ⚠
- p.Ser207Gly Single submitter ⚠
- p.Ser219Pro Single submitter ⚠
- p.Ser21Leu Single submitter ⚠
- p.Ser269Phe Single submitter ⚠
- p.Ser2Trp Single submitter ⚠
- p.Ser392Gly Single submitter ⚠
- p.Ser399Pro Single submitter ⚠
- p.Val254Ile Single submitter ⚠
- p.Val270Ile Single submitter ⚠
- p.Val400Leu Single submitter ⚠
- p.Val62Ala Single submitter ⚠
- p.Val86Ile Single submitter ⚠