ANKRD13A — 62 ClinVar variants
All ClinVar germline ANKRD13A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
2 Likely benign · 60 Uncertain significance
Full ANKRD13A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD13A p.Ala522Thr Uncertain significance Single submitter
- ANKRD13A p.Arg156Cys Uncertain significance Single submitter
- ANKRD13A p.Arg156His Uncertain significance Single submitter
- ANKRD13A p.Arg201Leu Uncertain significance Single submitter
- ANKRD13A p.Arg225Gln Uncertain significance Single submitter
- ANKRD13A p.Arg226Gln Uncertain significance Single submitter
- ANKRD13A p.Arg356Gly Uncertain significance Single submitter
- ANKRD13A p.Arg42Gln Uncertain significance Single submitter
- ANKRD13A p.Arg58Gln Uncertain significance Single submitter
- ANKRD13A p.Asp144Asn Uncertain significance Single submitter
- ANKRD13A p.Asp194Gly Uncertain significance Single submitter
- ANKRD13A p.Gln206Glu Uncertain significance Single submitter
- ANKRD13A p.Glu118Lys Uncertain significance Single submitter
- ANKRD13A p.Glu222Asp Uncertain significance Single submitter
- ANKRD13A p.Glu289Gly Uncertain significance Single submitter
- ANKRD13A p.Glu436Ala Uncertain significance Single submitter
- ANKRD13A p.Glu486Lys Uncertain significance Single submitter
- ANKRD13A p.Gly315Arg Uncertain significance Single submitter
- ANKRD13A p.Gly52Glu Uncertain significance Single submitter
- ANKRD13A p.His10Asn Uncertain significance Single submitter
- ANKRD13A p.His309Tyr Uncertain significance Single submitter
- ANKRD13A p.His479Arg Uncertain significance Single submitter
- ANKRD13A p.Ile148Val Uncertain significance Single submitter
- ANKRD13A p.Ile411Thr Uncertain significance Single submitter
- ANKRD13A p.Ile492Leu Uncertain significance Single submitter
- ANKRD13A p.Leu505Phe Uncertain significance Single submitter
- ANKRD13A p.Leu572Arg Uncertain significance Single submitter
- ANKRD13A p.Lys267Met Uncertain significance Single submitter
- ANKRD13A p.Phe130Leu Uncertain significance Single submitter
- ANKRD13A p.Pro508Arg Uncertain significance Single submitter
- ANKRD13A p.Ser439Pro Uncertain significance Single submitter
- ANKRD13A p.Thr286Ile Uncertain significance Single submitter
- ANKRD13A p.Thr323Ala Uncertain significance Single submitter
- ANKRD13A p.Tyr470Cys Uncertain significance Single submitter
- ANKRD13A p.Val145Ile Uncertain significance Single submitter
- ANKRD13A p.Val261Ile Uncertain significance Single submitter
- ANKRD13A p.Val478Ala Uncertain significance Single submitter
- ANKRD13A p.Val90Ala Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- ANKRD13A p.Ala527Ser Uncertain significance Single submitter
- ANKRD13A p.Ala65Val Uncertain significance Single submitter
- ANKRD13A p.Arg174His Uncertain significance Single submitter
- ANKRD13A p.Arg210Cys Uncertain significance Single submitter
- ANKRD13A p.Arg225Trp Uncertain significance Single submitter
- ANKRD13A p.Arg571Gln Uncertain significance Single submitter
- ANKRD13A p.Arg571Trp Uncertain significance Single submitter
- ANKRD13A p.Asn191Ser Uncertain significance Single submitter
- ANKRD13A p.Asn272Asp Uncertain significance Single submitter
- ANKRD13A p.Asn325Lys Uncertain significance Single submitter
- ANKRD13A p.Gln377Glu Uncertain significance Single submitter
- ANKRD13A p.Glu287Lys Uncertain significance Single submitter
- ANKRD13A p.Glu467Lys Uncertain significance Single submitter
- ANKRD13A p.Glu70Ala Uncertain significance Single submitter
- ANKRD13A p.His63Arg Uncertain significance Single submitter
- ANKRD13A p.Pro230Ser Uncertain significance Single submitter
- ANKRD13A p.Ser151Asn Uncertain significance Single submitter
- ANKRD13A p.Ser437Phe Uncertain significance Single submitter
- ANKRD13A p.Ser439Cys Uncertain significance Single submitter
- ANKRD13A p.Ser542Arg Uncertain significance Single submitter
- ANKRD13A p.Thr92Ile Uncertain significance Single submitter
- ANKRD13A p.Val442Met Uncertain significance Single submitter
All ANKRD13A variants
Likely benign 2
- p.His452Gln Single submitter
- p.Ser220Gly Single submitter
Uncertain significance 60
- p.Ala522Thr Single submitter ⚠
- p.Ala527Ser Single submitter ⚠
- p.Ala65Val Single submitter ⚠
- p.Arg156Cys Single submitter ⚠
- p.Arg156His Single submitter ⚠
- p.Arg174His Single submitter ⚠
- p.Arg201Leu Single submitter ⚠
- p.Arg210Cys Single submitter ⚠
- p.Arg225Gln Single submitter ⚠
- p.Arg225Trp Single submitter ⚠
- p.Arg226Gln Single submitter ⚠
- p.Arg356Gly Single submitter ⚠
- p.Arg42Gln Single submitter ⚠
- p.Arg571Gln Single submitter ⚠
- p.Arg571Trp Single submitter ⚠
- p.Arg58Gln Single submitter ⚠
- p.Asn191Ser Single submitter ⚠
- p.Asn272Asp Single submitter ⚠
- p.Asn325Lys Single submitter ⚠
- p.Asp144Asn Single submitter ⚠
- p.Asp194Gly Single submitter ⚠
- p.Gln206Glu Single submitter ⚠
- p.Gln377Glu Single submitter ⚠
- p.Glu118Lys Single submitter ⚠
- p.Glu222Asp Single submitter ⚠
- p.Glu287Lys Single submitter ⚠
- p.Glu289Gly Single submitter ⚠
- p.Glu436Ala Single submitter ⚠
- p.Glu467Lys Single submitter ⚠
- p.Glu486Lys Single submitter ⚠
- p.Glu70Ala Single submitter ⚠
- p.Gly315Arg Single submitter ⚠
- p.Gly52Glu Single submitter ⚠
- p.His10Asn Single submitter ⚠
- p.His309Tyr Single submitter ⚠
- p.His479Arg Single submitter ⚠
- p.His63Arg Single submitter ⚠
- p.Ile148Val Single submitter ⚠
- p.Ile411Thr Single submitter ⚠
- p.Ile492Leu Single submitter ⚠
- p.Leu505Phe Single submitter ⚠
- p.Leu572Arg Single submitter ⚠
- p.Lys267Met Single submitter ⚠
- p.Phe130Leu Single submitter ⚠
- p.Pro230Ser Single submitter ⚠
- p.Pro508Arg Single submitter ⚠
- p.Ser151Asn Single submitter ⚠
- p.Ser437Phe Single submitter ⚠
- p.Ser439Cys Single submitter ⚠
- p.Ser439Pro Single submitter ⚠
- p.Ser542Arg Single submitter ⚠
- p.Thr286Ile Single submitter ⚠
- p.Thr323Ala Single submitter ⚠
- p.Thr92Ile Single submitter ⚠
- p.Tyr470Cys Single submitter ⚠
- p.Val145Ile Single submitter ⚠
- p.Val261Ile Single submitter ⚠
- p.Val442Met Single submitter ⚠
- p.Val478Ala Single submitter ⚠
- p.Val90Ala Single submitter ⚠