ANKRD13D — 94 ClinVar variants
All ClinVar germline ANKRD13D variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
1 Likely benign · 93 Uncertain significance
Full ANKRD13D gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD13D p.Ala118Val Uncertain significance Single submitter
- ANKRD13D p.Ala223Val Uncertain significance Single submitter
- ANKRD13D p.Ala315Gly Uncertain significance Single submitter
- ANKRD13D p.Ala441Val Uncertain significance Single submitter
- ANKRD13D p.Ala536Thr Uncertain significance Single submitter
- ANKRD13D p.Arg116His Uncertain significance Single submitter
- ANKRD13D p.Arg150Gln Uncertain significance Single submitter
- ANKRD13D p.Arg150Trp Uncertain significance Single submitter
- ANKRD13D p.Arg172Gln Uncertain significance Single submitter
- ANKRD13D p.Arg193Gln Uncertain significance Single submitter
- ANKRD13D p.Arg238His Uncertain significance Single submitter
- ANKRD13D p.Arg344Gln Uncertain significance Single submitter
- ANKRD13D p.Arg401His Uncertain significance Single submitter
- ANKRD13D p.Arg475His Uncertain significance Single submitter
- ANKRD13D p.Arg515Gln Uncertain significance Single submitter
- ANKRD13D p.Arg515Trp Uncertain significance Single submitter
- ANKRD13D p.Arg535Trp Uncertain significance Single submitter
- ANKRD13D p.Arg578Trp Uncertain significance Single submitter
- ANKRD13D p.Arg586Gly Uncertain significance Single submitter
- ANKRD13D p.Arg596Gln Uncertain significance Single submitter
- ANKRD13D p.Arg596Trp Uncertain significance Single submitter
- ANKRD13D p.Asn239Ser Uncertain significance Single submitter
- ANKRD13D p.Gln117Glu Uncertain significance Single submitter
- ANKRD13D p.Gln595Glu Uncertain significance Single submitter
- ANKRD13D p.Gln90Leu Uncertain significance Single submitter
- ANKRD13D p.Glu152Gly Uncertain significance Single submitter
- ANKRD13D p.Glu351Lys Uncertain significance Single submitter
- ANKRD13D p.Glu477Lys Uncertain significance Single submitter
- ANKRD13D p.Glu529Lys Uncertain significance Single submitter
- ANKRD13D p.Glu604Gln Uncertain significance Single submitter
- ANKRD13D p.Gly295Glu Uncertain significance Single submitter
- ANKRD13D p.Gly314Arg Uncertain significance Single submitter
- ANKRD13D p.Gly467Ala Uncertain significance Single submitter
- ANKRD13D p.Gly517Ser Uncertain significance Single submitter
- ANKRD13D p.His234Leu Uncertain significance Single submitter
- ANKRD13D p.Ile230Val Uncertain significance Single submitter
- ANKRD13D p.Ile350Val Uncertain significance Single submitter
- ANKRD13D p.Ile398Thr Uncertain significance Single submitter
- ANKRD13D p.Ile410Thr Uncertain significance Single submitter
- ANKRD13D p.Ile422Val Uncertain significance Single submitter
- ANKRD13D p.Leu235Val Uncertain significance Single submitter
- ANKRD13D p.Leu479His Uncertain significance Single submitter
- ANKRD13D p.Lys114Gln Uncertain significance Single submitter
- ANKRD13D p.Lys393Arg Uncertain significance Single submitter
- ANKRD13D p.Met215Thr Uncertain significance Single submitter
- ANKRD13D p.Met473Val Uncertain significance Single submitter
- ANKRD13D p.Pro331Arg Uncertain significance Single submitter
- ANKRD13D p.Pro454Leu Uncertain significance Single submitter
- ANKRD13D p.Pro478Arg Uncertain significance Single submitter
- ANKRD13D p.Pro553Leu Uncertain significance Single submitter
- ANKRD13D p.Ser269Asn Uncertain significance Single submitter
- ANKRD13D p.Ser330Phe Uncertain significance Single submitter
- ANKRD13D p.Ser601Thr Uncertain significance Single submitter
- ANKRD13D p.Thr204Pro Uncertain significance Single submitter
- ANKRD13D p.Thr281Met Uncertain significance Single submitter
- ANKRD13D p.Val408Ile Uncertain significance Single submitter
- ANKRD13D p.Val439Leu Uncertain significance Single submitter
- ANKRD13D p.Val461Met Uncertain significance Single submitter
- ANKRD13D p.Val470Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- ANKRD13D p.Glu164Lys Uncertain significance Single submitter
- ANKRD13D p.Lys114Asn Uncertain significance Single submitter
- ANKRD13D p.Phe359Leu Uncertain significance Single submitter
- ANKRD13D p.Ser224Arg Uncertain significance Single submitter
- ANKRD13D p.Ser224Thr Uncertain significance Single submitter
- ANKRD13D p.Val147Leu Uncertain significance Single submitter
All ANKRD13D variants
Likely benign 1
- p.Asn451Ser Single submitter
Uncertain significance 93
- p.Ala118Val Single submitter ⚠
- p.Ala223Val Single submitter ⚠
- p.Ala315Gly Single submitter ⚠
- p.Ala441Val Single submitter ⚠
- p.Ala498Gly Single submitter
- p.Ala536Thr Single submitter ⚠
- p.Arg116His Single submitter ⚠
- p.Arg146Cys Single submitter
- p.Arg150Gln Single submitter ⚠
- p.Arg150Trp Single submitter ⚠
- p.Arg170Gln Single submitter
- p.Arg172Gln Single submitter ⚠
- p.Arg18Trp Single submitter
- p.Arg193Gln Single submitter ⚠
- p.Arg225His Single submitter
- p.Arg238His Single submitter ⚠
- p.Arg344Gln Single submitter ⚠
- p.Arg348His Single submitter
- p.Arg348Leu Single submitter
- p.Arg39His Single submitter
- p.Arg401His Single submitter ⚠
- p.Arg421His Single submitter
- p.Arg475His Single submitter ⚠
- p.Arg515Gln Single submitter ⚠
- p.Arg515Trp Single submitter ⚠
- p.Arg535Trp Single submitter ⚠
- p.Arg578Trp Single submitter ⚠
- p.Arg586Gly Single submitter ⚠
- p.Arg596Gln Single submitter ⚠
- p.Arg596Trp Single submitter ⚠
- p.Asn239Ser Single submitter ⚠
- p.Asp143Asn Single submitter
- p.Asp382Asn Single submitter
- p.Cys430Phe Single submitter
- p.Gln117Glu Single submitter ⚠
- p.Gln595Glu Single submitter ⚠
- p.Gln90Leu Single submitter ⚠
- p.Glu152Gly Single submitter ⚠
- p.Glu164Lys Single submitter ⚠
- p.Glu264Lys Single submitter
- p.Glu351Lys Single submitter ⚠
- p.Glu477Lys Single submitter ⚠
- p.Glu529Lys Single submitter ⚠
- p.Glu604Gln Single submitter ⚠
- p.Gly248Ala Single submitter
- p.Gly295Glu Single submitter ⚠
- p.Gly314Arg Single submitter ⚠
- p.Gly467Ala Single submitter ⚠
- p.Gly517Ser Single submitter ⚠
- p.Gly73Ser Single submitter
- p.His11Pro Single submitter
- p.His234Leu Single submitter ⚠
- p.Ile230Val Single submitter ⚠
- p.Ile350Val Single submitter ⚠
- p.Ile398Thr Single submitter ⚠
- p.Ile410Thr Single submitter ⚠
- p.Ile422Val Single submitter ⚠
- p.Leu13Val Single submitter
- p.Leu201Pro Single submitter
- p.Leu235Val Single submitter ⚠
- p.Leu479His Single submitter ⚠
- p.Lys114Asn Single submitter ⚠
- p.Lys114Gln Single submitter ⚠
- p.Lys256Asn Single submitter
- p.Lys393Arg Single submitter ⚠
- p.Met215Thr Single submitter ⚠
- p.Met473Val Single submitter ⚠
- p.Phe163Leu Single submitter
- p.Phe359Ile Single submitter
- p.Phe359Leu Single submitter ⚠
- p.Phe8Cys Single submitter
- p.Pro331Arg Single submitter ⚠
- p.Pro379His Single submitter
- p.Pro38Ser Single submitter
- p.Pro454Leu Single submitter ⚠
- p.Pro478Arg Single submitter ⚠
- p.Pro553Leu Single submitter ⚠
- p.Ser224Arg Single submitter ⚠
- p.Ser224Thr Single submitter ⚠
- p.Ser269Asn Single submitter ⚠
- p.Ser330Phe Single submitter ⚠
- p.Ser601Thr Single submitter ⚠
- p.Thr130Ile Single submitter
- p.Thr204Pro Single submitter ⚠
- p.Thr281Met Single submitter ⚠
- p.Thr423Ala Single submitter
- p.Val147Leu Single submitter ⚠
- p.Val408Ile Single submitter ⚠
- p.Val439Leu Single submitter ⚠
- p.Val461Met Single submitter ⚠
- p.Val470Met Single submitter ⚠
- p.Gly84Val No assertion criteria
- p.Leu434fs No assertion criteria ANKRD13D-related condition