ANKRD16 — 61 ClinVar variants
All ClinVar germline ANKRD16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
5 Likely benign · 56 Uncertain significance
Full ANKRD16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD16 p.Ala234Ser Uncertain significance Single submitter
- ANKRD16 p.Ala240Thr Uncertain significance Single submitter
- ANKRD16 p.Ala359Thr Uncertain significance Single submitter
- ANKRD16 p.Arg146Gln Uncertain significance Single submitter
- ANKRD16 p.Arg20Leu Uncertain significance Single submitter
- ANKRD16 p.Arg347Gly Uncertain significance Single submitter
- ANKRD16 p.Arg348Lys Uncertain significance Single submitter
- ANKRD16 p.Asp202Asn Uncertain significance Single submitter
- ANKRD16 p.Asp219Asn Uncertain significance Single submitter
- ANKRD16 p.Asp226Asn Uncertain significance Single submitter
- ANKRD16 p.Gln154Arg Uncertain significance Single submitter
- ANKRD16 p.Gly339Val Uncertain significance Single submitter
- ANKRD16 p.Gly34Arg Uncertain significance Single submitter
- ANKRD16 p.His181Arg Uncertain significance Single submitter
- ANKRD16 p.His76Gln Uncertain significance Single submitter
- ANKRD16 p.Ile218Val Uncertain significance Single submitter
- ANKRD16 p.Ile255Leu Uncertain significance Single submitter
- ANKRD16 p.Leu209Ser Uncertain significance Single submitter
- ANKRD16 p.Lys101Arg Uncertain significance Single submitter
- ANKRD16 p.Lys188Arg Uncertain significance Single submitter
- ANKRD16 p.Met110Leu Uncertain significance Single submitter
- ANKRD16 p.Met360Val Uncertain significance Single submitter
- ANKRD16 p.Pro35Ser Uncertain significance Single submitter
- ANKRD16 p.Ser233Ala Uncertain significance Single submitter
- ANKRD16 p.Thr166Ala Uncertain significance Single submitter
- ANKRD16 p.Trp164Cys Uncertain significance Single submitter
- ANKRD16 p.Val206Ile Uncertain significance Single submitter
Predictors split 30
The independent predictors disagree with each other — read with care.
- ANKRD16 p.Ala208Thr Uncertain significance Single submitter
- ANKRD16 p.Ala21Ser Uncertain significance Single submitter
- ANKRD16 p.Ala36Thr Uncertain significance Single submitter
- ANKRD16 p.Arg93Gln Uncertain significance Single submitter
- ANKRD16 p.Arg93Trp Uncertain significance Single submitter
- ANKRD16 p.Arg9Ser Uncertain significance Single submitter
- ANKRD16 p.Asp104Asn Uncertain significance Single submitter
- ANKRD16 p.Asp265Gly Uncertain significance Single submitter
- ANKRD16 p.Asp38Asn Uncertain significance Single submitter
- ANKRD16 p.Cys231Phe Uncertain significance Single submitter
- ANKRD16 p.Cys43Arg Uncertain significance Single submitter
- ANKRD16 p.Gln27Leu Uncertain significance Single submitter
- ANKRD16 p.Gly118Arg Uncertain significance Single submitter
- ANKRD16 p.Gly239Arg Uncertain significance Single submitter
- ANKRD16 p.Gly94Glu Uncertain significance Single submitter
- ANKRD16 p.Leu132Met Uncertain significance Single submitter
- ANKRD16 p.Leu153Phe Uncertain significance Single submitter
- ANKRD16 p.Leu294Val Uncertain significance Single submitter
- ANKRD16 p.Leu345His Uncertain significance Single submitter
- ANKRD16 p.Leu40Val Uncertain significance Single submitter
- ANKRD16 p.Pro35Arg Uncertain significance Single submitter
- ANKRD16 p.Pro7Leu Uncertain significance Single submitter
- ANKRD16 p.Ser168Asn Uncertain significance Single submitter
- ANKRD16 p.Thr177Ile Uncertain significance Single submitter
- ANKRD16 p.Thr207Ala Uncertain significance Single submitter
- ANKRD16 p.Tyr89Cys Uncertain significance Single submitter
- ANKRD16 p.Val14Met Uncertain significance Single submitter
- ANKRD16 p.Val264Ile Likely benign Single submitter
- ANKRD16 p.Val268Met Uncertain significance Single submitter
- ANKRD16 p.Val52Leu Uncertain significance Single submitter
All ANKRD16 variants
Likely benign 5
- p.Ala208Pro Single submitter
- p.Ala323= Single submitter
- p.Gln328= Single submitter
- p.Gly162Asp Single submitter
- p.Val264Ile Single submitter ⚠
Uncertain significance 56
- p.Ala208Thr Single submitter ⚠
- p.Ala21Ser Single submitter ⚠
- p.Ala234Ser Single submitter ⚠
- p.Ala240Thr Single submitter ⚠
- p.Ala359Thr Single submitter ⚠
- p.Ala36Thr Single submitter ⚠
- p.Arg146Gln Single submitter ⚠
- p.Arg20Leu Single submitter ⚠
- p.Arg347Gly Single submitter ⚠
- p.Arg348Lys Single submitter ⚠
- p.Arg93Gln Single submitter ⚠
- p.Arg93Trp Single submitter ⚠
- p.Arg9Ser Single submitter ⚠
- p.Asp104Asn Single submitter ⚠
- p.Asp202Asn Single submitter ⚠
- p.Asp219Asn Single submitter ⚠
- p.Asp226Asn Single submitter ⚠
- p.Asp265Gly Single submitter ⚠
- p.Asp38Asn Single submitter ⚠
- p.Cys231Phe Single submitter ⚠
- p.Cys43Arg Single submitter ⚠
- p.Gln154Arg Single submitter ⚠
- p.Gln27Leu Single submitter ⚠
- p.Gly118Arg Single submitter ⚠
- p.Gly239Arg Single submitter ⚠
- p.Gly339Val Single submitter ⚠
- p.Gly34Arg Single submitter ⚠
- p.Gly94Glu Single submitter ⚠
- p.His181Arg Single submitter ⚠
- p.His76Gln Single submitter ⚠
- p.Ile218Val Single submitter ⚠
- p.Ile255Leu Single submitter ⚠
- p.Leu132Met Single submitter ⚠
- p.Leu153Phe Single submitter ⚠
- p.Leu209Ser Single submitter ⚠
- p.Leu294Val Single submitter ⚠
- p.Leu345His Single submitter ⚠
- p.Leu40Val Single submitter ⚠
- p.Lys101Arg Single submitter ⚠
- p.Lys188Arg Single submitter ⚠
- p.Met110Leu Single submitter ⚠
- p.Met360Val Single submitter ⚠
- p.Pro35Arg Single submitter ⚠
- p.Pro35Ser Single submitter ⚠
- p.Pro7Leu Single submitter ⚠
- p.Ser168Asn Single submitter ⚠
- p.Ser233Ala Single submitter ⚠
- p.Thr166Ala Single submitter ⚠
- p.Thr177Ile Single submitter ⚠
- p.Thr207Ala Single submitter ⚠
- p.Trp164Cys Single submitter ⚠
- p.Tyr89Cys Single submitter ⚠
- p.Val14Met Single submitter ⚠
- p.Val206Ile Single submitter ⚠
- p.Val268Met Single submitter ⚠
- p.Val52Leu Single submitter ⚠