ANKRD2 — 56 ClinVar variants
All ClinVar germline ANKRD2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
3 Benign · 1 Benign/Likely benign · 2 Likely benign · 50 Uncertain significance
Full ANKRD2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD2 p.Ala10Val Uncertain significance Single submitter
- ANKRD2 p.Ala128Val Uncertain significance Single submitter
- ANKRD2 p.Ala12Thr Uncertain significance Single submitter
- ANKRD2 p.Ala311Val Uncertain significance Single submitter
- ANKRD2 p.Arg155Trp Uncertain significance Single submitter
- ANKRD2 p.Arg21Gln Uncertain significance Single submitter
- ANKRD2 p.Arg301Gln Uncertain significance Single submitter
- ANKRD2 p.Asp278Gly Uncertain significance Single submitter
- ANKRD2 p.Asp34Asn Uncertain significance Single submitter
- ANKRD2 p.Asp42Val Uncertain significance Single submitter
- ANKRD2 p.Cys195Arg Uncertain significance Single submitter
- ANKRD2 p.Gln12Lys Uncertain significance Single submitter
- ANKRD2 p.Gln294His Uncertain significance Single submitter
- ANKRD2 p.Gln297Leu Uncertain significance Single submitter
- ANKRD2 p.Glu131Val Uncertain significance Single submitter
- ANKRD2 p.Glu312Gly Uncertain significance Single submitter
- ANKRD2 p.Glu66Gln Uncertain significance Single submitter
- ANKRD2 p.Glu6Lys Uncertain significance Single submitter
- ANKRD2 p.Glu9Lys Uncertain significance Single submitter
- ANKRD2 p.Gly132Glu Uncertain significance Single submitter
- ANKRD2 p.Gly144Arg Uncertain significance Single submitter
- ANKRD2 p.Gly144Trp Uncertain significance Single submitter
- ANKRD2 p.Gly197Arg Uncertain significance Single submitter
- ANKRD2 p.His313Tyr Uncertain significance Single submitter
- ANKRD2 p.Ile18Met Uncertain significance Single submitter
- ANKRD2 p.Pro111Leu Uncertain significance Single submitter
- ANKRD2 p.Pro23Ser Uncertain significance Single submitter
- ANKRD2 p.Pro289Leu Uncertain significance Single submitter
- ANKRD2 p.Pro307Thr Uncertain significance Single submitter
- ANKRD2 p.Ser106Trp Uncertain significance Single submitter
- ANKRD2 p.Thr189Ala Uncertain significance Single submitter
- ANKRD2 p.Thr290Met Uncertain significance Single submitter
- ANKRD2 p.Thr326Asn Uncertain significance Single submitter
- ANKRD2 p.Val180Gly Uncertain significance Single submitter
- ANKRD2 p.Val233Met Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- ANKRD2 p.Pro119Leu Benign/Likely benign Multiple submitters
- ANKRD2 p.Arg100Pro Uncertain significance Single submitter
- ANKRD2 p.Arg155Gln Uncertain significance Single submitter
- ANKRD2 p.Arg265Leu Uncertain significance Single submitter
- ANKRD2 p.Arg69Gly Uncertain significance Single submitter
- ANKRD2 p.Arg69Leu Uncertain significance Single submitter
- ANKRD2 p.Asn247Lys Uncertain significance Single submitter
- ANKRD2 p.Glu9Gly Uncertain significance Single submitter
- ANKRD2 p.Gly165Cys Uncertain significance Single submitter
- ANKRD2 p.Leu75Val Uncertain significance Single submitter
- ANKRD2 p.Trp296Cys Uncertain significance Single submitter
- ANKRD2 p.Tyr266Cys Uncertain significance Single submitter
- ANKRD2 p.Val120Ala Uncertain significance Single submitter
- ANKRD2 p.Val202Leu Uncertain significance Single submitter
- ANKRD2 p.Val293Ala Uncertain significance Single submitter
All ANKRD2 variants
Benign 3
- p.Ala285= Multiple submitters
- p.Pro6Arg Multiple submitters
- p.Trp58_Pro59delinsSer Single submitter
Benign/Likely benign 1
- p.Pro119Leu Multiple submitters ⚠
Likely benign 2
- p.Ala105= Single submitter
- p.Met167Val Single submitter
Uncertain significance 50
- p.Ala10Val Single submitter ⚠
- p.Ala128Val Single submitter ⚠
- p.Ala12Thr Single submitter ⚠
- p.Ala311Val Single submitter ⚠
- p.Arg100Pro Single submitter ⚠
- p.Arg155Gln Single submitter ⚠
- p.Arg155Trp Single submitter ⚠
- p.Arg21Gln Single submitter ⚠
- p.Arg265Leu Single submitter ⚠
- p.Arg301Gln Single submitter ⚠
- p.Arg69Gly Single submitter ⚠
- p.Arg69Leu Single submitter ⚠
- p.Asn247Lys Single submitter ⚠
- p.Asp278Gly Single submitter ⚠
- p.Asp34Asn Single submitter ⚠
- p.Asp42Val Single submitter ⚠
- p.Cys195Arg Single submitter ⚠
- p.Gln12Lys Single submitter ⚠
- p.Gln294His Single submitter ⚠
- p.Gln297Leu Single submitter ⚠
- p.Glu131Val Single submitter ⚠
- p.Glu312Gly Single submitter ⚠
- p.Glu66Gln Single submitter ⚠
- p.Glu6Lys Single submitter ⚠
- p.Glu9Gly Single submitter ⚠
- p.Glu9Lys Single submitter ⚠
- p.Gly132Glu Single submitter ⚠
- p.Gly144Arg Single submitter ⚠
- p.Gly144Trp Single submitter ⚠
- p.Gly165Cys Single submitter ⚠
- p.Gly197Arg Single submitter ⚠
- p.His313Tyr Single submitter ⚠
- p.Ile18Met Single submitter ⚠
- p.Leu75Val Single submitter ⚠
- p.Pro111Leu Single submitter ⚠
- p.Pro223Ala Single submitter
- p.Pro23Ser Single submitter ⚠
- p.Pro289Leu Single submitter ⚠
- p.Pro307Thr Single submitter ⚠
- p.Ser106Trp Single submitter ⚠
- p.Thr189Ala Single submitter ⚠
- p.Thr290Met Single submitter ⚠
- p.Thr326Asn Single submitter ⚠
- p.Trp296Cys Single submitter ⚠
- p.Tyr266Cys Single submitter ⚠
- p.Val120Ala Single submitter ⚠
- p.Val180Gly Single submitter ⚠
- p.Val202Leu Single submitter ⚠
- p.Val233Met Single submitter ⚠
- p.Val293Ala Single submitter ⚠