ANKRD22 — 24 ClinVar variants
All ClinVar germline ANKRD22 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
24 Uncertain significance
Full ANKRD22 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD22 p.Arg158Gly Uncertain significance Single submitter
- ANKRD22 p.Asn70Lys Uncertain significance Single submitter
- ANKRD22 p.Cys133Arg Uncertain significance Single submitter
- ANKRD22 p.Cys133Gly Uncertain significance Single submitter
- ANKRD22 p.Gln182Glu Uncertain significance Single submitter
- ANKRD22 p.Gly125Val Uncertain significance Single submitter
- ANKRD22 p.Leu101Phe Uncertain significance Single submitter
- ANKRD22 p.Leu106Ile Uncertain significance Single submitter
- ANKRD22 p.Leu121Pro Uncertain significance Single submitter
- ANKRD22 p.Leu68Pro Uncertain significance Single submitter
- ANKRD22 p.Ser149Phe Uncertain significance Single submitter
- ANKRD22 p.Thr86Ser Uncertain significance Single submitter
- ANKRD22 p.Val108Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- ANKRD22 p.Ala32Gly Uncertain significance Single submitter
- ANKRD22 p.Asn114Lys Uncertain significance Single submitter
- ANKRD22 p.Asn147Lys Uncertain significance Single submitter
- ANKRD22 p.Glu169Asp Uncertain significance Single submitter
- ANKRD22 p.His140Leu Uncertain significance Single submitter
- ANKRD22 p.Ile183Thr Uncertain significance Single submitter
- ANKRD22 p.Ile94Asn Uncertain significance Single submitter
- ANKRD22 p.Ile9Val Uncertain significance Single submitter
- ANKRD22 p.Lys164Asn Uncertain significance Single submitter
- ANKRD22 p.Phe58Leu Uncertain significance Single submitter
- ANKRD22 p.Thr137Ala Uncertain significance Single submitter
All ANKRD22 variants
Uncertain significance 24
- p.Ala32Gly Single submitter ⚠
- p.Arg158Gly Single submitter ⚠
- p.Asn114Lys Single submitter ⚠
- p.Asn147Lys Single submitter ⚠
- p.Asn70Lys Single submitter ⚠
- p.Cys133Arg Single submitter ⚠
- p.Cys133Gly Single submitter ⚠
- p.Gln182Glu Single submitter ⚠
- p.Glu169Asp Single submitter ⚠
- p.Gly125Val Single submitter ⚠
- p.His140Leu Single submitter ⚠
- p.Ile183Thr Single submitter ⚠
- p.Ile94Asn Single submitter ⚠
- p.Ile9Val Single submitter ⚠
- p.Leu101Phe Single submitter ⚠
- p.Leu106Ile Single submitter ⚠
- p.Leu121Pro Single submitter ⚠
- p.Leu68Pro Single submitter ⚠
- p.Lys164Asn Single submitter ⚠
- p.Phe58Leu Single submitter ⚠
- p.Ser149Phe Single submitter ⚠
- p.Thr137Ala Single submitter ⚠
- p.Thr86Ser Single submitter ⚠
- p.Val108Ala Single submitter ⚠