ANKRD23 — 60 ClinVar variants
All ClinVar germline ANKRD23 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
4 Likely benign · 56 Uncertain significance
Full ANKRD23 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD23 p.Ala166Ser Uncertain significance Single submitter
- ANKRD23 p.Ala43Val Uncertain significance Single submitter
- ANKRD23 p.Ala73Gly Uncertain significance Single submitter
- ANKRD23 p.Ala73Pro Uncertain significance Single submitter
- ANKRD23 p.Arg206Gln Uncertain significance Single submitter
- ANKRD23 p.Arg221Trp Uncertain significance Single submitter
- ANKRD23 p.Arg288Cys Uncertain significance Single submitter
- ANKRD23 p.Arg291Pro Uncertain significance Single submitter
- ANKRD23 p.Arg291Trp Uncertain significance Single submitter
- ANKRD23 p.Arg302His Uncertain significance Single submitter
- ANKRD23 p.Arg61Thr Uncertain significance Single submitter
- ANKRD23 p.Arg82Gln Uncertain significance Single submitter
- ANKRD23 p.Arg82Trp Uncertain significance Single submitter
- ANKRD23 p.Asp141Tyr Uncertain significance Single submitter
- ANKRD23 p.Asp224Asn Uncertain significance Single submitter
- ANKRD23 p.Asp244Gly Uncertain significance Single submitter
- ANKRD23 p.Asp285Asn Uncertain significance Single submitter
- ANKRD23 p.Asp35Asn Uncertain significance Single submitter
- ANKRD23 p.Asp35Gly Uncertain significance Single submitter
- ANKRD23 p.Gln123Pro Uncertain significance Single submitter
- ANKRD23 p.Gln158Arg Uncertain significance Single submitter
- ANKRD23 p.Gln287Lys Uncertain significance Single submitter
- ANKRD23 p.Gln80Leu Uncertain significance Single submitter
- ANKRD23 p.Glu16Lys Uncertain significance Single submitter
- ANKRD23 p.Gly134Arg Uncertain significance Single submitter
- ANKRD23 p.Gly155Ser Uncertain significance Single submitter
- ANKRD23 p.Gly167Val Uncertain significance Single submitter
- ANKRD23 p.Gly254Ser Uncertain significance Single submitter
- ANKRD23 p.His300Tyr Uncertain significance Single submitter
- ANKRD23 p.Leu112Pro Uncertain significance Single submitter
- ANKRD23 p.Leu143Phe Uncertain significance Single submitter
- ANKRD23 p.Leu193Arg Uncertain significance Single submitter
- ANKRD23 p.Leu20Phe Uncertain significance Single submitter
- ANKRD23 p.Leu269Pro Uncertain significance Single submitter
- ANKRD23 p.Lys154Gln Uncertain significance Single submitter
- ANKRD23 p.Lys257Gln Uncertain significance Single submitter
- ANKRD23 p.Met114Ile Uncertain significance Single submitter
- ANKRD23 p.Met259Leu Uncertain significance Single submitter
- ANKRD23 p.Phe62Cys Uncertain significance Single submitter
- ANKRD23 p.Pro91His Uncertain significance Single submitter
- ANKRD23 p.Pro95Arg Uncertain significance Single submitter
- ANKRD23 p.Ser255Ile Uncertain significance Single submitter
- ANKRD23 p.Ser64Asn Uncertain significance Single submitter
- ANKRD23 p.Tyr265Ser Uncertain significance Single submitter
- ANKRD23 p.Val10Leu Uncertain significance Single submitter
- ANKRD23 p.Val271Leu Uncertain significance Single submitter
- ANKRD23 p.Val99Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- ANKRD23 p.Ala172Thr Uncertain significance Single submitter
- ANKRD23 p.Ala172Val Uncertain significance Single submitter
- ANKRD23 p.Ala238Thr Uncertain significance Single submitter
- ANKRD23 p.Arg145Cys Uncertain significance Single submitter
- ANKRD23 p.Gln239Glu Uncertain significance Single submitter
- ANKRD23 p.Ser276Pro Uncertain significance Single submitter
All ANKRD23 variants
Likely benign 4
- p.Arg202Gln Single submitter
- p.Arg272Gln Single submitter
- p.Gly111Asp Single submitter
- p.Pro223Ser Single submitter
Uncertain significance 56
- p.Ala166Ser Single submitter ⚠
- p.Ala172Thr Single submitter ⚠
- p.Ala172Val Single submitter ⚠
- p.Ala238Thr Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Ala73Gly Single submitter ⚠
- p.Ala73Pro Single submitter ⚠
- p.Arg145Cys Single submitter ⚠
- p.Arg206Gln Single submitter ⚠
- p.Arg221Trp Single submitter ⚠
- p.Arg288Cys Single submitter ⚠
- p.Arg291Pro Single submitter ⚠
- p.Arg291Trp Single submitter ⚠
- p.Arg302His Single submitter ⚠
- p.Arg61Thr Single submitter ⚠
- p.Arg82Gln Single submitter ⚠
- p.Arg82Trp Single submitter ⚠
- p.Asp141Tyr Single submitter ⚠
- p.Asp224Asn Single submitter ⚠
- p.Asp244Gly Single submitter ⚠
- p.Asp285Asn Single submitter ⚠
- p.Asp35Asn Single submitter ⚠
- p.Asp35Gly Single submitter ⚠
- p.Gln123Pro Single submitter ⚠
- p.Gln158Arg Single submitter ⚠
- p.Gln239Glu Single submitter ⚠
- p.Gln287Lys Single submitter ⚠
- p.Gln80Leu Single submitter ⚠
- p.Glu16Lys Single submitter ⚠
- p.Gly134Arg Single submitter ⚠
- p.Gly155Ser Single submitter ⚠
- p.Gly167Val Single submitter ⚠
- p.Gly254Ser Single submitter ⚠
- p.Gly266Arg Single submitter
- p.His300Tyr Single submitter ⚠
- p.Leu112Pro Single submitter ⚠
- p.Leu143Phe Single submitter ⚠
- p.Leu193Arg Single submitter ⚠
- p.Leu20Phe Single submitter ⚠
- p.Leu269Pro Single submitter ⚠
- p.Lys154Gln Single submitter ⚠
- p.Lys257Gln Single submitter ⚠
- p.Met114Ile Single submitter ⚠
- p.Met259Leu Single submitter ⚠
- p.Phe62Cys Single submitter ⚠
- p.Pro91His Single submitter ⚠
- p.Pro95Arg Single submitter ⚠
- p.Ser255Ile Single submitter ⚠
- p.Ser276Pro Single submitter ⚠
- p.Ser64Asn Single submitter ⚠
- p.Thr278Asn Single submitter
- p.Tyr265Ser Single submitter ⚠
- p.Val10Leu Single submitter ⚠
- p.Val251Ala Single submitter
- p.Val271Leu Single submitter ⚠
- p.Val99Leu Single submitter ⚠