ANKRD33 — 65 ClinVar variants
All ClinVar germline ANKRD33 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
4 Likely benign · 61 Uncertain significance
Full ANKRD33 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD33 p.Ala113Val Uncertain significance Single submitter
- ANKRD33 p.Ala124Val Uncertain significance Single submitter
- ANKRD33 p.Ala207Val Uncertain significance Single submitter
- ANKRD33 p.Ala407Thr Uncertain significance Single submitter
- ANKRD33 p.Arg195His Uncertain significance Single submitter
- ANKRD33 p.Arg199Trp Uncertain significance Single submitter
- ANKRD33 p.Arg210Gln Uncertain significance Single submitter
- ANKRD33 p.Arg212His Uncertain significance Single submitter
- ANKRD33 p.Arg242Gly Uncertain significance Single submitter
- ANKRD33 p.Arg249Gln Uncertain significance Single submitter
- ANKRD33 p.Arg30Gly Uncertain significance Single submitter
- ANKRD33 p.Asp166Asn Uncertain significance Single submitter
- ANKRD33 p.Asp235Asn Uncertain significance Single submitter
- ANKRD33 p.Asp238Asn Uncertain significance Single submitter
- ANKRD33 p.Cys414Gly Uncertain significance Single submitter
- ANKRD33 p.Gln272Glu Uncertain significance Single submitter
- ANKRD33 p.Gln357Arg Uncertain significance Single submitter
- ANKRD33 p.Glu253Ala Uncertain significance Single submitter
- ANKRD33 p.Glu262Lys Uncertain significance Single submitter
- ANKRD33 p.Gly117Cys Uncertain significance Single submitter
- ANKRD33 p.Gly14Arg Uncertain significance Single submitter
- ANKRD33 p.His258Tyr Uncertain significance Single submitter
- ANKRD33 p.Ile27Phe Uncertain significance Single submitter
- ANKRD33 p.Leu269Phe Uncertain significance Single submitter
- ANKRD33 p.Leu293Phe Uncertain significance Single submitter
- ANKRD33 p.Leu346Phe Uncertain significance Single submitter
- ANKRD33 p.Leu430Phe Uncertain significance Single submitter
- ANKRD33 p.Leu60Gln Uncertain significance Single submitter
- ANKRD33 p.Lys440Thr Uncertain significance Single submitter
- ANKRD33 p.Lys55Ile Uncertain significance Single submitter
- ANKRD33 p.Lys87Arg Uncertain significance Single submitter
- ANKRD33 p.Met136Thr Uncertain significance Single submitter
- ANKRD33 p.Pro121Ala Uncertain significance Single submitter
- ANKRD33 p.Pro25Ala Uncertain significance Single submitter
- ANKRD33 p.Pro261Ser Uncertain significance Single submitter
- ANKRD33 p.Pro264Leu Uncertain significance Single submitter
- ANKRD33 p.Pro281Ser Uncertain significance Single submitter
- ANKRD33 p.Pro297Ser Uncertain significance Single submitter
- ANKRD33 p.Pro350Leu Uncertain significance Single submitter
- ANKRD33 p.Pro353Ser Uncertain significance Single submitter
- ANKRD33 p.Pro367Leu Uncertain significance Single submitter
- ANKRD33 p.Pro395Arg Uncertain significance Single submitter
- ANKRD33 p.Pro418Thr Uncertain significance Single submitter
- ANKRD33 p.Ser334Leu Uncertain significance Single submitter
- ANKRD33 p.Thr202Met Uncertain significance Single submitter
- ANKRD33 p.Trp263Leu Uncertain significance Single submitter
- ANKRD33 p.Val178Met Uncertain significance Single submitter
- ANKRD33 p.Val219Met Uncertain significance Single submitter
- ANKRD33 p.Val26Gly Uncertain significance Single submitter
- ANKRD33 p.Val38Ala Uncertain significance Single submitter
- ANKRD33 p.Val61Phe Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- ANKRD33 p.Arg244Trp Uncertain significance Single submitter
- ANKRD33 p.Asp162Asn Uncertain significance Single submitter
- ANKRD33 p.Gly134Val Uncertain significance Single submitter
- ANKRD33 p.Gly190Val Uncertain significance Single submitter
- ANKRD33 p.Leu287Arg Uncertain significance Single submitter
- ANKRD33 p.Met170Thr Uncertain significance Single submitter
- ANKRD33 p.Thr217Ile Uncertain significance Single submitter
- ANKRD33 p.Thr226Met Uncertain significance Single submitter
All ANKRD33 variants
Likely benign 4
- p.Ala450= Single submitter
- p.Arg437= Single submitter
- p.Ile379Met Single submitter
- p.Pro416= Single submitter
Uncertain significance 61
- p.Ala113Val Single submitter ⚠
- p.Ala124Val Single submitter ⚠
- p.Ala203Val Single submitter
- p.Ala207Val Single submitter ⚠
- p.Ala407Thr Single submitter ⚠
- p.Arg195His Single submitter ⚠
- p.Arg199Trp Single submitter ⚠
- p.Arg210Gln Single submitter ⚠
- p.Arg212His Single submitter ⚠
- p.Arg242Gly Single submitter ⚠
- p.Arg244Trp Single submitter ⚠
- p.Arg249Gln Single submitter ⚠
- p.Arg30Gly Single submitter ⚠
- p.Asp162Asn Single submitter ⚠
- p.Asp166Asn Single submitter ⚠
- p.Asp235Asn Single submitter ⚠
- p.Asp238Asn Single submitter ⚠
- p.Cys414Gly Single submitter ⚠
- p.Gln272Glu Single submitter ⚠
- p.Gln357Arg Single submitter ⚠
- p.Glu253Ala Single submitter ⚠
- p.Glu262Lys Single submitter ⚠
- p.Gly117Cys Single submitter ⚠
- p.Gly134Val Single submitter ⚠
- p.Gly14Arg Single submitter ⚠
- p.Gly190Val Single submitter ⚠
- p.His258Tyr Single submitter ⚠
- p.Ile27Phe Single submitter ⚠
- p.Leu269Phe Single submitter ⚠
- p.Leu287Arg Single submitter ⚠
- p.Leu293Phe Single submitter ⚠
- p.Leu346Phe Single submitter ⚠
- p.Leu430Phe Single submitter ⚠
- p.Leu60Gln Single submitter ⚠
- p.Lys440Thr Single submitter ⚠
- p.Lys55Ile Single submitter ⚠
- p.Lys87Arg Single submitter ⚠
- p.Met136Thr Single submitter ⚠
- p.Met170Thr Single submitter ⚠
- p.Pro121Ala Single submitter ⚠
- p.Pro25Ala Single submitter ⚠
- p.Pro261Ser Single submitter ⚠
- p.Pro264Leu Single submitter ⚠
- p.Pro281Ser Single submitter ⚠
- p.Pro297Ser Single submitter ⚠
- p.Pro350Leu Single submitter ⚠
- p.Pro353Ser Single submitter ⚠
- p.Pro367Leu Single submitter ⚠
- p.Pro395Arg Single submitter ⚠
- p.Pro418Thr Single submitter ⚠
- p.Pro429Leu Single submitter
- p.Ser334Leu Single submitter ⚠
- p.Thr202Met Single submitter ⚠
- p.Thr217Ile Single submitter ⚠
- p.Thr226Met Single submitter ⚠
- p.Trp263Leu Single submitter ⚠
- p.Val178Met Single submitter ⚠
- p.Val219Met Single submitter ⚠
- p.Val26Gly Single submitter ⚠
- p.Val38Ala Single submitter ⚠
- p.Val61Phe Single submitter ⚠