ANKRD33B — 90 ClinVar variants
All ClinVar germline ANKRD33B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 86 flagged for review →
4 Likely benign · 86 Uncertain significance
Full ANKRD33B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 86
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD33B p.Ala168Val Uncertain significance Single submitter
- ANKRD33B p.Ala214Val Uncertain significance Single submitter
- ANKRD33B p.Ala274Thr Uncertain significance Single submitter
- ANKRD33B p.Ala319Val Uncertain significance Single submitter
- ANKRD33B p.Ala376Thr Uncertain significance Single submitter
- ANKRD33B p.Ala433Val Uncertain significance Single submitter
- ANKRD33B p.Ala72Ser Uncertain significance Single submitter
- ANKRD33B p.Arg119Pro Uncertain significance Single submitter
- ANKRD33B p.Arg119Ser Uncertain significance Single submitter
- ANKRD33B p.Arg222His Uncertain significance Single submitter
- ANKRD33B p.Arg249Cys Uncertain significance Single submitter
- ANKRD33B p.Arg370Gln Uncertain significance Single submitter
- ANKRD33B p.Arg427Gln Uncertain significance Single submitter
- ANKRD33B p.Arg427Leu Uncertain significance Single submitter
- ANKRD33B p.Arg493Lys Uncertain significance Single submitter
- ANKRD33B p.Arg91Leu Uncertain significance Single submitter
- ANKRD33B p.Asn156Thr Uncertain significance Single submitter
- ANKRD33B p.Asn97Ser Uncertain significance Single submitter
- ANKRD33B p.Asp118Glu Uncertain significance Single submitter
- ANKRD33B p.Asp375Gly Uncertain significance Single submitter
- ANKRD33B p.Cys143Tyr Uncertain significance Single submitter
- ANKRD33B p.Gln244Arg Uncertain significance Single submitter
- ANKRD33B p.Gln357Lys Uncertain significance Single submitter
- ANKRD33B p.Gln373Arg Uncertain significance Single submitter
- ANKRD33B p.Glu359Asp Uncertain significance Single submitter
- ANKRD33B p.Glu466Lys Uncertain significance Single submitter
- ANKRD33B p.Glu484Lys Uncertain significance Single submitter
- ANKRD33B p.Glu70Gly Uncertain significance Single submitter
- ANKRD33B p.Gly124Ser Uncertain significance Single submitter
- ANKRD33B p.Gly213Val Uncertain significance Single submitter
- ANKRD33B p.Gly381Asp Uncertain significance Single submitter
- ANKRD33B p.Gly451Ser Uncertain significance Single submitter
- ANKRD33B p.Met195Val Uncertain significance Single submitter
- ANKRD33B p.Met199Val Uncertain significance Single submitter
- ANKRD33B p.Met243Leu Uncertain significance Single submitter
- ANKRD33B p.Phe61Val Uncertain significance Single submitter
- ANKRD33B p.Pro25Arg Uncertain significance Single submitter
- ANKRD33B p.Pro388Leu Uncertain significance Single submitter
- ANKRD33B p.Pro388Ser Uncertain significance Single submitter
- ANKRD33B p.Pro432Arg Uncertain significance Single submitter
- ANKRD33B p.Ser450Arg Uncertain significance Single submitter
- ANKRD33B p.Ser71Gly Uncertain significance Single submitter
- ANKRD33B p.Ser82Thr Uncertain significance Single submitter
- ANKRD33B p.Thr171Ala Uncertain significance Single submitter
- ANKRD33B p.Thr232Ile Uncertain significance Single submitter
- ANKRD33B p.Tyr37His Uncertain significance Single submitter
- ANKRD33B p.Tyr59His Uncertain significance Single submitter
- ANKRD33B p.Val320Leu Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- ANKRD33B p.Asp301Asn Uncertain significance Multiple submitters
- ANKRD33B p.Ala158Pro Uncertain significance Single submitter
- ANKRD33B p.Ala348Val Uncertain significance Single submitter
- ANKRD33B p.Ala350Val Uncertain significance Single submitter
- ANKRD33B p.Ala365Val Uncertain significance Single submitter
- ANKRD33B p.Arg202Gln Uncertain significance Single submitter
- ANKRD33B p.Arg241His Uncertain significance Single submitter
- ANKRD33B p.Arg349Trp Uncertain significance Single submitter
- ANKRD33B p.Arg370Trp Uncertain significance Single submitter
- ANKRD33B p.Arg486Cys Uncertain significance Single submitter
- ANKRD33B p.Arg486His Uncertain significance Single submitter
- ANKRD33B p.Asp204Asn Uncertain significance Single submitter
- ANKRD33B p.Asp360Asn Uncertain significance Single submitter
- ANKRD33B p.Cys324Ser Uncertain significance Single submitter
- ANKRD33B p.Glu248Lys Uncertain significance Single submitter
- ANKRD33B p.Glu38Lys Uncertain significance Single submitter
- ANKRD33B p.Glu39Gln Uncertain significance Single submitter
- ANKRD33B p.Glu474Ala Uncertain significance Single submitter
- ANKRD33B p.Leu246Met Uncertain significance Single submitter
- ANKRD33B p.Pro267Leu Uncertain significance Single submitter
- ANKRD33B p.Pro293Gln Uncertain significance Single submitter
- ANKRD33B p.Pro293Leu Uncertain significance Single submitter
- ANKRD33B p.Pro332His Uncertain significance Single submitter
- ANKRD33B p.Pro332Ser Uncertain significance Single submitter
- ANKRD33B p.Pro333Leu Uncertain significance Single submitter
- ANKRD33B p.Pro354Leu Uncertain significance Single submitter
- ANKRD33B p.Pro396Leu Uncertain significance Single submitter
- ANKRD33B p.Ser331Arg Uncertain significance Single submitter
- ANKRD33B p.Ser331Gly Uncertain significance Single submitter
- ANKRD33B p.Ser44Trp Uncertain significance Single submitter
- ANKRD33B p.Thr18Ile Uncertain significance Single submitter
- ANKRD33B p.Thr292Met Uncertain significance Single submitter
- ANKRD33B p.Trp150Gly Uncertain significance Single submitter
- ANKRD33B p.Val137Leu Uncertain significance Single submitter
- ANKRD33B p.Val148Ile Uncertain significance Single submitter
- ANKRD33B p.Val342Met Uncertain significance Single submitter
- ANKRD33B p.Val417Met Uncertain significance Single submitter
- ANKRD33B p.Val83Gly Uncertain significance Single submitter
All ANKRD33B variants
Likely benign 4
- p.Ala400Ser Single submitter
- p.Cys286Phe Single submitter
- p.Ile455Leu Single submitter
- p.Val287Leu Single submitter
Uncertain significance 86
- p.Asp301Asn Multiple submitters ⚠
- p.Ala158Pro Single submitter ⚠
- p.Ala168Val Single submitter ⚠
- p.Ala214Val Single submitter ⚠
- p.Ala274Thr Single submitter ⚠
- p.Ala319Val Single submitter ⚠
- p.Ala348Val Single submitter ⚠
- p.Ala350Val Single submitter ⚠
- p.Ala365Val Single submitter ⚠
- p.Ala376Thr Single submitter ⚠
- p.Ala433Val Single submitter ⚠
- p.Ala72Ser Single submitter ⚠
- p.Arg119Pro Single submitter ⚠
- p.Arg119Ser Single submitter ⚠
- p.Arg202Gln Single submitter ⚠
- p.Arg222His Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg249Cys Single submitter ⚠
- p.Arg349Trp Single submitter ⚠
- p.Arg370Gln Single submitter ⚠
- p.Arg370Trp Single submitter ⚠
- p.Arg427Gln Single submitter ⚠
- p.Arg427Leu Single submitter ⚠
- p.Arg486Cys Single submitter ⚠
- p.Arg486His Single submitter ⚠
- p.Arg493Lys Single submitter ⚠
- p.Arg91Leu Single submitter ⚠
- p.Asn156Thr Single submitter ⚠
- p.Asn97Ser Single submitter ⚠
- p.Asp118Glu Single submitter ⚠
- p.Asp204Asn Single submitter ⚠
- p.Asp360Asn Single submitter ⚠
- p.Asp375Gly Single submitter ⚠
- p.Cys143Tyr Single submitter ⚠
- p.Cys324Ser Single submitter ⚠
- p.Gln244Arg Single submitter ⚠
- p.Gln357Lys Single submitter ⚠
- p.Gln373Arg Single submitter ⚠
- p.Glu248Lys Single submitter ⚠
- p.Glu359Asp Single submitter ⚠
- p.Glu38Lys Single submitter ⚠
- p.Glu39Gln Single submitter ⚠
- p.Glu466Lys Single submitter ⚠
- p.Glu474Ala Single submitter ⚠
- p.Glu484Lys Single submitter ⚠
- p.Glu70Gly Single submitter ⚠
- p.Gly124Ser Single submitter ⚠
- p.Gly213Val Single submitter ⚠
- p.Gly381Asp Single submitter ⚠
- p.Gly451Ser Single submitter ⚠
- p.Leu246Met Single submitter ⚠
- p.Met195Val Single submitter ⚠
- p.Met199Val Single submitter ⚠
- p.Met243Leu Single submitter ⚠
- p.Phe61Val Single submitter ⚠
- p.Pro25Arg Single submitter ⚠
- p.Pro267Leu Single submitter ⚠
- p.Pro293Gln Single submitter ⚠
- p.Pro293Leu Single submitter ⚠
- p.Pro332His Single submitter ⚠
- p.Pro332Ser Single submitter ⚠
- p.Pro333Leu Single submitter ⚠
- p.Pro354Leu Single submitter ⚠
- p.Pro388Leu Single submitter ⚠
- p.Pro388Ser Single submitter ⚠
- p.Pro396Leu Single submitter ⚠
- p.Pro432Arg Single submitter ⚠
- p.Ser331Arg Single submitter ⚠
- p.Ser331Gly Single submitter ⚠
- p.Ser44Trp Single submitter ⚠
- p.Ser450Arg Single submitter ⚠
- p.Ser71Gly Single submitter ⚠
- p.Ser82Thr Single submitter ⚠
- p.Thr171Ala Single submitter ⚠
- p.Thr18Ile Single submitter ⚠
- p.Thr232Ile Single submitter ⚠
- p.Thr292Met Single submitter ⚠
- p.Trp150Gly Single submitter ⚠
- p.Tyr37His Single submitter ⚠
- p.Tyr59His Single submitter ⚠
- p.Val137Leu Single submitter ⚠
- p.Val148Ile Single submitter ⚠
- p.Val320Leu Single submitter ⚠
- p.Val342Met Single submitter ⚠
- p.Val417Met Single submitter ⚠
- p.Val83Gly Single submitter ⚠