ANKRD34C — 74 ClinVar variants
All ClinVar germline ANKRD34C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 74 flagged for review →
74 Uncertain significance
Full ANKRD34C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 74
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD34C p.Ala186Val Uncertain significance Single submitter
- ANKRD34C p.Ala242Ser Uncertain significance Single submitter
- ANKRD34C p.Ala264Thr Uncertain significance Single submitter
- ANKRD34C p.Arg117Cys Uncertain significance Single submitter
- ANKRD34C p.Arg117His Uncertain significance Single submitter
- ANKRD34C p.Arg179Lys Uncertain significance Single submitter
- ANKRD34C p.Arg243His Uncertain significance Single submitter
- ANKRD34C p.Arg268His Uncertain significance Single submitter
- ANKRD34C p.Arg268Leu Uncertain significance Single submitter
- ANKRD34C p.Arg454His Uncertain significance Single submitter
- ANKRD34C p.Arg96Gly Uncertain significance Single submitter
- ANKRD34C p.Asn227Ser Uncertain significance Single submitter
- ANKRD34C p.Asn238Ser Uncertain significance Single submitter
- ANKRD34C p.Asn300Lys Uncertain significance Single submitter
- ANKRD34C p.Asn467His Uncertain significance Single submitter
- ANKRD34C p.Asn79His Uncertain significance Single submitter
- ANKRD34C p.Asp199Asn Uncertain significance Single submitter
- ANKRD34C p.Asp208Gly Uncertain significance Single submitter
- ANKRD34C p.Asp381His Uncertain significance Single submitter
- ANKRD34C p.Asp5His Uncertain significance Single submitter
- ANKRD34C p.Cys185Arg Uncertain significance Single submitter
- ANKRD34C p.Cys93Ser Uncertain significance Single submitter
- ANKRD34C p.Gln213His Uncertain significance Single submitter
- ANKRD34C p.Gln316Lys Uncertain significance Single submitter
- ANKRD34C p.Gln316Pro Uncertain significance Single submitter
- ANKRD34C p.Glu376Lys Uncertain significance Single submitter
- ANKRD34C p.Gly387Arg Uncertain significance Single submitter
- ANKRD34C p.Gly399Ser Uncertain significance Single submitter
- ANKRD34C p.His180Asn Uncertain significance Single submitter
- ANKRD34C p.His273Tyr Uncertain significance Single submitter
- ANKRD34C p.Ile191Thr Uncertain significance Single submitter
- ANKRD34C p.Ile285Leu Uncertain significance Single submitter
- ANKRD34C p.Ile394Phe Uncertain significance Single submitter
- ANKRD34C p.Ile474Val Uncertain significance Single submitter
- ANKRD34C p.Leu198Pro Uncertain significance Single submitter
- ANKRD34C p.Lys305Gln Uncertain significance Single submitter
- ANKRD34C p.Met2Val Uncertain significance Single submitter
- ANKRD34C p.Met494Val Uncertain significance Single submitter
- ANKRD34C p.Met519Val Uncertain significance Single submitter
- ANKRD34C p.Pro217Ala Uncertain significance Single submitter
- ANKRD34C p.Pro217Leu Uncertain significance Single submitter
- ANKRD34C p.Pro386Leu Uncertain significance Single submitter
- ANKRD34C p.Pro438Leu Uncertain significance Single submitter
- ANKRD34C p.Pro472Leu Uncertain significance Single submitter
- ANKRD34C p.Pro475Thr Uncertain significance Single submitter
- ANKRD34C p.Pro499Thr Uncertain significance Single submitter
- ANKRD34C p.Ser266Leu Uncertain significance Single submitter
- ANKRD34C p.Ser284Asn Uncertain significance Single submitter
- ANKRD34C p.Ser371Pro Uncertain significance Single submitter
- ANKRD34C p.Ser489Gly Uncertain significance Single submitter
- ANKRD34C p.Thr163Ala Uncertain significance Single submitter
- ANKRD34C p.Tyr380Cys Uncertain significance Single submitter
- ANKRD34C p.Val351Ala Uncertain significance Single submitter
- ANKRD34C p.Val495Ile Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- ANKRD34C p.Ala259Val Uncertain significance Single submitter
- ANKRD34C p.Arg293Trp Uncertain significance Single submitter
- ANKRD34C p.Arg420Trp Uncertain significance Single submitter
- ANKRD34C p.Arg436Cys Uncertain significance Single submitter
- ANKRD34C p.Glu45Ala Uncertain significance Single submitter
- ANKRD34C p.Glu45Lys Uncertain significance Single submitter
- ANKRD34C p.Gly336Cys Uncertain significance Single submitter
- ANKRD34C p.Gly446Asp Uncertain significance Single submitter
- ANKRD34C p.Gly99Glu Uncertain significance Single submitter
- ANKRD34C p.Ile384Met Uncertain significance Single submitter
- ANKRD34C p.Leu239Phe Uncertain significance Single submitter
- ANKRD34C p.Leu372His Uncertain significance Single submitter
- ANKRD34C p.Leu470Met Uncertain significance Single submitter
- ANKRD34C p.Leu487Phe Uncertain significance Single submitter
- ANKRD34C p.Lys165Glu Uncertain significance Single submitter
- ANKRD34C p.Pro201Arg Uncertain significance Single submitter
- ANKRD34C p.Ser261Leu Uncertain significance Single submitter
- ANKRD34C p.Ser297Cys Uncertain significance Single submitter
- ANKRD34C p.Ser364Phe Uncertain significance Single submitter
- ANKRD34C p.Ser414Ala Uncertain significance Single submitter
All ANKRD34C variants
Uncertain significance 74
- p.Ala186Val Single submitter ⚠
- p.Ala242Ser Single submitter ⚠
- p.Ala259Val Single submitter ⚠
- p.Ala264Thr Single submitter ⚠
- p.Arg117Cys Single submitter ⚠
- p.Arg117His Single submitter ⚠
- p.Arg179Lys Single submitter ⚠
- p.Arg243His Single submitter ⚠
- p.Arg268His Single submitter ⚠
- p.Arg268Leu Single submitter ⚠
- p.Arg293Trp Single submitter ⚠
- p.Arg420Trp Single submitter ⚠
- p.Arg436Cys Single submitter ⚠
- p.Arg454His Single submitter ⚠
- p.Arg96Gly Single submitter ⚠
- p.Asn227Ser Single submitter ⚠
- p.Asn238Ser Single submitter ⚠
- p.Asn300Lys Single submitter ⚠
- p.Asn467His Single submitter ⚠
- p.Asn79His Single submitter ⚠
- p.Asp199Asn Single submitter ⚠
- p.Asp208Gly Single submitter ⚠
- p.Asp381His Single submitter ⚠
- p.Asp5His Single submitter ⚠
- p.Cys185Arg Single submitter ⚠
- p.Cys93Ser Single submitter ⚠
- p.Gln213His Single submitter ⚠
- p.Gln316Lys Single submitter ⚠
- p.Gln316Pro Single submitter ⚠
- p.Glu376Lys Single submitter ⚠
- p.Glu45Ala Single submitter ⚠
- p.Glu45Lys Single submitter ⚠
- p.Gly336Cys Single submitter ⚠
- p.Gly387Arg Single submitter ⚠
- p.Gly399Ser Single submitter ⚠
- p.Gly446Asp Single submitter ⚠
- p.Gly99Glu Single submitter ⚠
- p.His180Asn Single submitter ⚠
- p.His273Tyr Single submitter ⚠
- p.Ile191Thr Single submitter ⚠
- p.Ile285Leu Single submitter ⚠
- p.Ile384Met Single submitter ⚠
- p.Ile394Phe Single submitter ⚠
- p.Ile474Val Single submitter ⚠
- p.Leu198Pro Single submitter ⚠
- p.Leu239Phe Single submitter ⚠
- p.Leu372His Single submitter ⚠
- p.Leu470Met Single submitter ⚠
- p.Leu487Phe Single submitter ⚠
- p.Lys165Glu Single submitter ⚠
- p.Lys305Gln Single submitter ⚠
- p.Met2Val Single submitter ⚠
- p.Met494Val Single submitter ⚠
- p.Met519Val Single submitter ⚠
- p.Pro201Arg Single submitter ⚠
- p.Pro217Ala Single submitter ⚠
- p.Pro217Leu Single submitter ⚠
- p.Pro386Leu Single submitter ⚠
- p.Pro438Leu Single submitter ⚠
- p.Pro472Leu Single submitter ⚠
- p.Pro475Thr Single submitter ⚠
- p.Pro499Thr Single submitter ⚠
- p.Ser261Leu Single submitter ⚠
- p.Ser266Leu Single submitter ⚠
- p.Ser284Asn Single submitter ⚠
- p.Ser297Cys Single submitter ⚠
- p.Ser364Phe Single submitter ⚠
- p.Ser371Pro Single submitter ⚠
- p.Ser414Ala Single submitter ⚠
- p.Ser489Gly Single submitter ⚠
- p.Thr163Ala Single submitter ⚠
- p.Tyr380Cys Single submitter ⚠
- p.Val351Ala Single submitter ⚠
- p.Val495Ile Single submitter ⚠