ANKRD35 — 163 ClinVar variants

All ClinVar germline ANKRD35 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 149 flagged for review →

1 Conflicting · 14 Likely benign · 148 Uncertain significance

Full ANKRD35 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 149

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

ANKRD35 p.Gln250His Conflicting Single submitter

Predictors lean, ClinVar uncertain 94

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 54

The independent predictors disagree with each other — read with care.

All ANKRD35 variants

Conflicting classifications of pathogenicity 1

p.Gln250His Single submitter ⚠

Likely benign 14

p.Ala166Thr Single submitter
p.Arg311Gln Single submitter
p.Arg543Gln Single submitter
p.Arg670Gln Single submitter
p.Arg730Gln Single submitter
p.Arg981Gln Single submitter
p.Gln719Arg Single submitter
p.Leu471Pro Single submitter
p.Leu693Arg Single submitter
p.Lys187= Single submitter
p.Lys357Arg Single submitter
p.Met518Leu Single submitter
p.Met682Val Single submitter
p.Ser295= Single submitter

Uncertain significance 148

p.Ala133Val Single submitter ⚠
p.Ala144Thr Single submitter ⚠
p.Ala202Gly Single submitter ⚠
p.Ala212Thr Single submitter ⚠
p.Ala241Ser Single submitter ⚠
p.Ala480Ser Single submitter ⚠
p.Ala486Glu Single submitter ⚠
p.Ala521Thr Single submitter ⚠
p.Ala531Thr Single submitter ⚠
p.Ala573Thr Single submitter ⚠
p.Ala598Ser Single submitter ⚠
p.Ala662Val Single submitter ⚠
p.Ala686Ser Single submitter ⚠
p.Ala922Val Single submitter ⚠
p.Ala946Pro Single submitter ⚠
p.Ala980Ser Single submitter ⚠
p.Arg121Cys Single submitter ⚠
p.Arg121His Single submitter ⚠
p.Arg16Lys Single submitter ⚠
p.Arg178Gln Single submitter ⚠
p.Arg244Trp Single submitter ⚠
p.Arg245Gln Single submitter ⚠
p.Arg247Trp Single submitter ⚠
p.Arg299Gly Single submitter ⚠
p.Arg306Trp Single submitter ⚠
p.Arg30Ser Single submitter ⚠
p.Arg35Leu Single submitter ⚠
p.Arg363Gln Single submitter ⚠
p.Arg363Trp Single submitter ⚠
p.Arg419Lys Single submitter ⚠
p.Arg46Gln Single submitter ⚠
p.Arg510Pro Single submitter ⚠
p.Arg543Trp Single submitter ⚠
p.Arg638Gly Single submitter ⚠
p.Arg638Pro Single submitter ⚠
p.Arg654Gly Single submitter ⚠
p.Arg691Gln Single submitter ⚠
p.Arg739Gln Single submitter ⚠
p.Arg739Pro Single submitter ⚠
p.Arg899Pro Single submitter ⚠
p.Arg924Gln Single submitter ⚠
p.Arg948Gln Single submitter ⚠
p.Arg948Trp Single submitter ⚠
p.Asn120Ser Single submitter ⚠
p.Asn754Lys Single submitter ⚠
p.Asn964Asp Single submitter ⚠
p.Asn974His Single submitter ⚠
p.Asn990Asp Single submitter ⚠
p.Asp141Asn Single submitter ⚠
p.Asp152Asn Single submitter ⚠
p.Asp186Glu Single submitter ⚠
p.Asp376His Single submitter ⚠
p.Asp455His Single submitter ⚠
p.Asp711His Single submitter ⚠
p.Asp785Tyr Single submitter ⚠
p.Cys102Arg Single submitter ⚠
p.Gln285Lys Single submitter ⚠
p.Gln490His Single submitter ⚠
p.Gln592Pro Single submitter ⚠
p.Gln784Glu Single submitter ⚠
p.Gln805His Single submitter ⚠
p.Glu119Asp Single submitter ⚠
p.Glu143Lys Single submitter ⚠
p.Glu15Asp Single submitter ⚠
p.Glu195Lys Single submitter ⚠
p.Glu203Gly Single submitter ⚠
p.Glu282Gln Single submitter ⚠
p.Glu284Asp Single submitter ⚠
p.Glu305Lys Single submitter ⚠
p.Glu614Gln Single submitter ⚠
p.Glu633Asp Single submitter ⚠
p.Glu688Gly Single submitter ⚠
p.Glu715Gln Single submitter ⚠
p.Glu877Asp Single submitter ⚠
p.Glu890Gly Single submitter ⚠
p.Glu932Gln Single submitter ⚠
p.Glu999Val Single submitter ⚠
p.Gly110Ser Single submitter ⚠
p.Gly209Glu Single submitter ⚠
p.Gly359Arg Single submitter ⚠
p.Gly410Ala Single submitter ⚠
p.Gly410Glu Single submitter ⚠
p.Gly472Val Single submitter ⚠
p.Gly554Arg Single submitter ⚠
p.Gly569Glu Single submitter ⚠
p.Gly632Arg Single submitter ⚠
p.Gly808Arg Single submitter ⚠
p.Gly87Glu Single submitter ⚠
p.Gly982Asp Single submitter ⚠
p.His142Gln Single submitter ⚠
p.His255Gln Single submitter ⚠
p.His986Tyr Single submitter ⚠
p.Ile168Thr Single submitter ⚠
p.Ile72Thr Single submitter ⚠
p.Ile969Phe Single submitter ⚠
p.Leu204Gln Single submitter ⚠
p.Leu252Pro Single submitter ⚠
p.Leu333Pro Single submitter ⚠
p.Leu344Val Single submitter ⚠
p.Leu545Met Single submitter ⚠
p.Leu708Pro Single submitter ⚠
p.Leu73Pro Single submitter ⚠
p.Leu954Pro Single submitter ⚠
p.Lys196Arg Single submitter ⚠
p.Lys23Asn Single submitter ⚠
p.Lys49Asn Single submitter ⚠
p.Lys586Glu Single submitter ⚠
p.Lys64Arg Single submitter ⚠
p.Lys837Thr Single submitter ⚠
p.Lys83Glu Single submitter ⚠
p.Met518Ile Single submitter ⚠
p.Pro156Leu Single submitter ⚠
p.Pro293Leu Single submitter ⚠
p.Pro428Arg Single submitter ⚠
p.Pro454Leu Single submitter ⚠
p.Pro475Ser Single submitter ⚠
p.Pro482Gln Single submitter ⚠
p.Pro57Ser Single submitter ⚠
p.Pro595Thr Single submitter ⚠
p.Pro658Ala Single submitter ⚠
p.Pro658Leu Single submitter ⚠
p.Ser161Leu Single submitter ⚠
p.Ser188Leu Single submitter ⚠
p.Ser188Trp Single submitter ⚠
p.Ser265Thr Single submitter ⚠
p.Ser295Leu Single submitter ⚠
p.Ser433Tyr Single submitter ⚠
p.Ser52Leu Single submitter ⚠
p.Ser56Ala Single submitter ⚠
p.Ser618Leu Single submitter ⚠
p.Ser776Phe Single submitter ⚠
p.Ser82Gly Single submitter ⚠
p.Thr155Arg Single submitter ⚠
p.Thr677Ile Single submitter ⚠
p.Thr687Ala Single submitter ⚠
p.Thr862Met Single submitter ⚠
p.Thr908Met Single submitter ⚠
p.Tyr414Asn Single submitter ⚠
p.Tyr860Cys Single submitter ⚠
p.Tyr972Cys Single submitter ⚠
p.Val105Phe Single submitter ⚠
p.Val148Met Single submitter ⚠
p.Val253Ile Single submitter ⚠
p.Val310Phe Single submitter ⚠
p.Val33Ala Single submitter ⚠
p.Val36Met Single submitter ⚠
p.Val502Ala Single submitter ⚠
p.Val779Met Single submitter ⚠