ANKRD40 — 38 ClinVar variants
All ClinVar germline ANKRD40 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
38 Uncertain significance
Full ANKRD40 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD40 p.Ala242Thr Uncertain significance Single submitter
- ANKRD40 p.Ala350Thr Uncertain significance Single submitter
- ANKRD40 p.Arg13Lys Uncertain significance Single submitter
- ANKRD40 p.Arg177Gln Uncertain significance Single submitter
- ANKRD40 p.Arg217Cys Uncertain significance Single submitter
- ANKRD40 p.Arg347Thr Uncertain significance Single submitter
- ANKRD40 p.Asn145Ser Uncertain significance Single submitter
- ANKRD40 p.Asn235Ser Uncertain significance Single submitter
- ANKRD40 p.Glu116Asp Uncertain significance Single submitter
- ANKRD40 p.Glu138Asp Uncertain significance Single submitter
- ANKRD40 p.Glu201Lys Uncertain significance Single submitter
- ANKRD40 p.Glu299Lys Uncertain significance Single submitter
- ANKRD40 p.Glu6Gln Uncertain significance Single submitter
- ANKRD40 p.Leu300Pro Uncertain significance Single submitter
- ANKRD40 p.Leu4Val Uncertain significance Single submitter
- ANKRD40 p.Met229Thr Uncertain significance Single submitter
- ANKRD40 p.Met258Thr Uncertain significance Single submitter
- ANKRD40 p.Pro166Leu Uncertain significance Single submitter
- ANKRD40 p.Pro170Ala Uncertain significance Single submitter
- ANKRD40 p.Pro176His Uncertain significance Single submitter
- ANKRD40 p.Pro205Leu Uncertain significance Single submitter
- ANKRD40 p.Pro228Ala Uncertain significance Single submitter
- ANKRD40 p.Pro243Leu Uncertain significance Single submitter
- ANKRD40 p.Pro314Ser Uncertain significance Single submitter
- ANKRD40 p.Ser154Leu Uncertain significance Single submitter
- ANKRD40 p.Ser230Phe Uncertain significance Single submitter
- ANKRD40 p.Thr180Pro Uncertain significance Single submitter
- ANKRD40 p.Thr237Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- ANKRD40 p.Asn122Lys Uncertain significance Single submitter
- ANKRD40 p.Asn2Tyr Uncertain significance Single submitter
- ANKRD40 p.Asp103Asn Uncertain significance Single submitter
- ANKRD40 p.Asp35His Uncertain significance Single submitter
- ANKRD40 p.Asp99Tyr Uncertain significance Single submitter
- ANKRD40 p.Gln11Leu Uncertain significance Single submitter
- ANKRD40 p.Gln290Lys Uncertain significance Single submitter
- ANKRD40 p.Met93Thr Uncertain significance Single submitter
- ANKRD40 p.Pro130Ser Uncertain significance Single submitter
- ANKRD40 p.Val190Glu Uncertain significance Single submitter
All ANKRD40 variants
Uncertain significance 38
- p.Ala242Thr Single submitter ⚠
- p.Ala350Thr Single submitter ⚠
- p.Arg13Lys Single submitter ⚠
- p.Arg177Gln Single submitter ⚠
- p.Arg217Cys Single submitter ⚠
- p.Arg347Thr Single submitter ⚠
- p.Asn122Lys Single submitter ⚠
- p.Asn145Ser Single submitter ⚠
- p.Asn235Ser Single submitter ⚠
- p.Asn2Tyr Single submitter ⚠
- p.Asp103Asn Single submitter ⚠
- p.Asp35His Single submitter ⚠
- p.Asp99Tyr Single submitter ⚠
- p.Gln11Leu Single submitter ⚠
- p.Gln290Lys Single submitter ⚠
- p.Glu116Asp Single submitter ⚠
- p.Glu138Asp Single submitter ⚠
- p.Glu201Lys Single submitter ⚠
- p.Glu299Lys Single submitter ⚠
- p.Glu6Gln Single submitter ⚠
- p.Leu300Pro Single submitter ⚠
- p.Leu4Val Single submitter ⚠
- p.Met229Thr Single submitter ⚠
- p.Met258Thr Single submitter ⚠
- p.Met93Thr Single submitter ⚠
- p.Pro130Ser Single submitter ⚠
- p.Pro166Leu Single submitter ⚠
- p.Pro170Ala Single submitter ⚠
- p.Pro176His Single submitter ⚠
- p.Pro205Leu Single submitter ⚠
- p.Pro228Ala Single submitter ⚠
- p.Pro243Leu Single submitter ⚠
- p.Pro314Ser Single submitter ⚠
- p.Ser154Leu Single submitter ⚠
- p.Ser230Phe Single submitter ⚠
- p.Thr180Pro Single submitter ⚠
- p.Thr237Met Single submitter ⚠
- p.Val190Glu Single submitter ⚠