ANKRD42 — 70 ClinVar variants
All ClinVar germline ANKRD42 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 70 flagged for review →
70 Uncertain significance
Full ANKRD42 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 70
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD42 p.Ala107Val Uncertain significance Single submitter
- ANKRD42 p.Ala111Val Uncertain significance Single submitter
- ANKRD42 p.Ala265Val Uncertain significance Single submitter
- ANKRD42 p.Arg171Gln Uncertain significance Single submitter
- ANKRD42 p.Arg294Leu Uncertain significance Single submitter
- ANKRD42 p.Arg35Gln Uncertain significance Single submitter
- ANKRD42 p.Asn191Ser Uncertain significance Single submitter
- ANKRD42 p.Asn290Ser Uncertain significance Single submitter
- ANKRD42 p.Asp124Asn Uncertain significance Single submitter
- ANKRD42 p.Asp156Gly Uncertain significance Single submitter
- ANKRD42 p.Asp286Asn Uncertain significance Single submitter
- ANKRD42 p.Asp286Glu Uncertain significance Single submitter
- ANKRD42 p.Asp393Tyr Uncertain significance Single submitter
- ANKRD42 p.Cys313Tyr Uncertain significance Single submitter
- ANKRD42 p.Gln143Leu Uncertain significance Single submitter
- ANKRD42 p.Gln246Lys Uncertain significance Single submitter
- ANKRD42 p.Gln261His Uncertain significance Single submitter
- ANKRD42 p.Gln261Pro Uncertain significance Single submitter
- ANKRD42 p.Glu351Gln Uncertain significance Single submitter
- ANKRD42 p.Glu352Lys Uncertain significance Single submitter
- ANKRD42 p.Glu451= Uncertain significance Single submitter
- ANKRD42 p.Gly104Cys Uncertain significance Single submitter
- ANKRD42 p.Gly448= Uncertain significance Single submitter
- ANKRD42 p.His77Leu Uncertain significance Single submitter
- ANKRD42 p.Ile113Thr Uncertain significance Single submitter
- ANKRD42 p.Ile185Thr Uncertain significance Single submitter
- ANKRD42 p.Ile30Val Uncertain significance Single submitter
- ANKRD42 p.Ile45Thr Uncertain significance Single submitter
- ANKRD42 p.Ile45Val Uncertain significance Single submitter
- ANKRD42 p.Leu132Arg Uncertain significance Single submitter
- ANKRD42 p.Leu76Arg Uncertain significance Single submitter
- ANKRD42 p.Leu80Ile Uncertain significance Single submitter
- ANKRD42 p.Lys274Asn Uncertain significance Single submitter
- ANKRD42 p.Met279Thr Uncertain significance Single submitter
- ANKRD42 p.Phe140Ser Uncertain significance Single submitter
- ANKRD42 p.Phe225Ser Uncertain significance Single submitter
- ANKRD42 p.Pro19Leu Uncertain significance Single submitter
- ANKRD42 p.Ser139Cys Uncertain significance Single submitter
- ANKRD42 p.Thr16Ile Uncertain significance Single submitter
- ANKRD42 p.Val154Met Uncertain significance Single submitter
Predictors split 30
The independent predictors disagree with each other — read with care.
- ANKRD42 p.Ala101Thr Uncertain significance Single submitter
- ANKRD42 p.Ala236Val Uncertain significance Single submitter
- ANKRD42 p.Ala322Val Uncertain significance Single submitter
- ANKRD42 p.Arg125Trp Uncertain significance Single submitter
- ANKRD42 p.Arg294His Uncertain significance Single submitter
- ANKRD42 p.Asn226Ser Uncertain significance Single submitter
- ANKRD42 p.Asp106Val Uncertain significance Single submitter
- ANKRD42 p.Asp234Ala Uncertain significance Single submitter
- ANKRD42 p.Asp286Val Uncertain significance Single submitter
- ANKRD42 p.Asp32Gly Uncertain significance Single submitter
- ANKRD42 p.Asp365His Uncertain significance Single submitter
- ANKRD42 p.Cys127Tyr Uncertain significance Single submitter
- ANKRD42 p.Glu361Lys Uncertain significance Single submitter
- ANKRD42 p.Gly126Arg Uncertain significance Single submitter
- ANKRD42 p.Gly321Arg Uncertain significance Single submitter
- ANKRD42 p.Gly331Arg Uncertain significance Single submitter
- ANKRD42 p.Ile99Val Uncertain significance Single submitter
- ANKRD42 p.Lys329Thr Uncertain significance Single submitter
- ANKRD42 p.Lys339Glu Uncertain significance Single submitter
- ANKRD42 p.Met145Thr Uncertain significance Single submitter
- ANKRD42 p.Met215Arg Uncertain significance Single submitter
- ANKRD42 p.Met215Lys Uncertain significance Single submitter
- ANKRD42 p.Met302Val Uncertain significance Single submitter
- ANKRD42 p.Pro129Ala Uncertain significance Single submitter
- ANKRD42 p.Ser184Ile Uncertain significance Single submitter
- ANKRD42 p.Ser21Phe Uncertain significance Single submitter
- ANKRD42 p.Thr219Met Uncertain significance Single submitter
- ANKRD42 p.Thr91Met Uncertain significance Single submitter
- ANKRD42 p.Trp181Arg Uncertain significance Single submitter
- ANKRD42 p.Val163Met Uncertain significance Single submitter
All ANKRD42 variants
Uncertain significance 70
- p.Ala101Thr Single submitter ⚠
- p.Ala107Val Single submitter ⚠
- p.Ala111Val Single submitter ⚠
- p.Ala236Val Single submitter ⚠
- p.Ala265Val Single submitter ⚠
- p.Ala322Val Single submitter ⚠
- p.Arg125Trp Single submitter ⚠
- p.Arg171Gln Single submitter ⚠
- p.Arg294His Single submitter ⚠
- p.Arg294Leu Single submitter ⚠
- p.Arg35Gln Single submitter ⚠
- p.Asn191Ser Single submitter ⚠
- p.Asn226Ser Single submitter ⚠
- p.Asn290Ser Single submitter ⚠
- p.Asp106Val Single submitter ⚠
- p.Asp124Asn Single submitter ⚠
- p.Asp156Gly Single submitter ⚠
- p.Asp234Ala Single submitter ⚠
- p.Asp286Asn Single submitter ⚠
- p.Asp286Glu Single submitter ⚠
- p.Asp286Val Single submitter ⚠
- p.Asp32Gly Single submitter ⚠
- p.Asp365His Single submitter ⚠
- p.Asp393Tyr Single submitter ⚠
- p.Cys127Tyr Single submitter ⚠
- p.Cys313Tyr Single submitter ⚠
- p.Gln143Leu Single submitter ⚠
- p.Gln246Lys Single submitter ⚠
- p.Gln261His Single submitter ⚠
- p.Gln261Pro Single submitter ⚠
- p.Glu351Gln Single submitter ⚠
- p.Glu352Lys Single submitter ⚠
- p.Glu361Lys Single submitter ⚠
- p.Glu451= Single submitter ⚠
- p.Gly104Cys Single submitter ⚠
- p.Gly126Arg Single submitter ⚠
- p.Gly321Arg Single submitter ⚠
- p.Gly331Arg Single submitter ⚠
- p.Gly448= Single submitter ⚠
- p.His77Leu Single submitter ⚠
- p.Ile113Thr Single submitter ⚠
- p.Ile185Thr Single submitter ⚠
- p.Ile30Val Single submitter ⚠
- p.Ile45Thr Single submitter ⚠
- p.Ile45Val Single submitter ⚠
- p.Ile99Val Single submitter ⚠
- p.Leu132Arg Single submitter ⚠
- p.Leu76Arg Single submitter ⚠
- p.Leu80Ile Single submitter ⚠
- p.Lys274Asn Single submitter ⚠
- p.Lys329Thr Single submitter ⚠
- p.Lys339Glu Single submitter ⚠
- p.Met145Thr Single submitter ⚠
- p.Met215Arg Single submitter ⚠
- p.Met215Lys Single submitter ⚠
- p.Met279Thr Single submitter ⚠
- p.Met302Val Single submitter ⚠
- p.Phe140Ser Single submitter ⚠
- p.Phe225Ser Single submitter ⚠
- p.Pro129Ala Single submitter ⚠
- p.Pro19Leu Single submitter ⚠
- p.Ser139Cys Single submitter ⚠
- p.Ser184Ile Single submitter ⚠
- p.Ser21Phe Single submitter ⚠
- p.Thr16Ile Single submitter ⚠
- p.Thr219Met Single submitter ⚠
- p.Thr91Met Single submitter ⚠
- p.Trp181Arg Single submitter ⚠
- p.Val154Met Single submitter ⚠
- p.Val163Met Single submitter ⚠