ANKRD45 — 38 ClinVar variants
All ClinVar germline ANKRD45 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
38 Uncertain significance
Full ANKRD45 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD45 p.Ala138Thr Uncertain significance Single submitter
- ANKRD45 p.Ala181Val Uncertain significance Single submitter
- ANKRD45 p.Ala249Gly Uncertain significance Single submitter
- ANKRD45 p.Arg122His Uncertain significance Single submitter
- ANKRD45 p.Arg142Trp Uncertain significance Single submitter
- ANKRD45 p.Arg145Lys Uncertain significance Single submitter
- ANKRD45 p.Cys244Ser Uncertain significance Single submitter
- ANKRD45 p.Gln89His Uncertain significance Single submitter
- ANKRD45 p.Glu105Lys Uncertain significance Single submitter
- ANKRD45 p.Glu10Asp Uncertain significance Single submitter
- ANKRD45 p.Glu144Gly Uncertain significance Single submitter
- ANKRD45 p.Glu23Val Uncertain significance Single submitter
- ANKRD45 p.Glu8Gly Uncertain significance Single submitter
- ANKRD45 p.Gly50Arg Uncertain significance Single submitter
- ANKRD45 p.Gly50Ser Uncertain significance Single submitter
- ANKRD45 p.Gly77Val Uncertain significance Single submitter
- ANKRD45 p.His115Asn Uncertain significance Single submitter
- ANKRD45 p.Ile136Thr Uncertain significance Single submitter
- ANKRD45 p.Ile200Val Uncertain significance Single submitter
- ANKRD45 p.Ile236Val Uncertain significance Single submitter
- ANKRD45 p.Leu114Ser Uncertain significance Single submitter
- ANKRD45 p.Leu123Val Uncertain significance Single submitter
- ANKRD45 p.Leu69Phe Uncertain significance Single submitter
- ANKRD45 p.Phe223Cys Uncertain significance Single submitter
- ANKRD45 p.Ser248Ile Uncertain significance Single submitter
- ANKRD45 p.Ser9Leu Uncertain significance Single submitter
- ANKRD45 p.Thr213Ile Uncertain significance Single submitter
- ANKRD45 p.Thr253Ile Uncertain significance Single submitter
- ANKRD45 p.Thr33Lys Uncertain significance Single submitter
- ANKRD45 p.Val233Leu Uncertain significance Single submitter
- ANKRD45 p.Val76Ile Uncertain significance Single submitter
- ANKRD45 p.Val92Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All ANKRD45 variants
Uncertain significance 38
- p.Ala138Thr Single submitter ⚠
- p.Ala181Val Single submitter ⚠
- p.Ala249Gly Single submitter ⚠
- p.Arg122His Single submitter ⚠
- p.Arg142Trp Single submitter ⚠
- p.Arg145Lys Single submitter ⚠
- p.Arg147Leu Single submitter ⚠
- p.Cys204Tyr Single submitter ⚠
- p.Cys244Ser Single submitter ⚠
- p.Gln89His Single submitter ⚠
- p.Glu105Lys Single submitter ⚠
- p.Glu10Asp Single submitter ⚠
- p.Glu144Gly Single submitter ⚠
- p.Glu23Val Single submitter ⚠
- p.Glu8Gly Single submitter ⚠
- p.Gly50Arg Single submitter ⚠
- p.Gly50Ser Single submitter ⚠
- p.Gly77Val Single submitter ⚠
- p.His115Asn Single submitter ⚠
- p.Ile136Thr Single submitter ⚠
- p.Ile200Val Single submitter ⚠
- p.Ile236Val Single submitter ⚠
- p.Leu103Pro Single submitter
- p.Leu114Ser Single submitter ⚠
- p.Leu123Val Single submitter ⚠
- p.Leu69Phe Single submitter ⚠
- p.Phe141Leu Single submitter ⚠
- p.Phe223Cys Single submitter ⚠
- p.Pro38Ser Single submitter ⚠
- p.Ser248Ile Single submitter ⚠
- p.Ser9Leu Single submitter ⚠
- p.Thr213Ile Single submitter ⚠
- p.Thr253Ile Single submitter ⚠
- p.Thr33Lys Single submitter ⚠
- p.Trp120Cys Single submitter ⚠
- p.Val233Leu Single submitter ⚠
- p.Val76Ile Single submitter ⚠
- p.Val92Met Single submitter ⚠