ANKRD46 — 22 ClinVar variants
All ClinVar germline ANKRD46 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
22 Uncertain significance
Full ANKRD46 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD46 p.Asn166Ser Uncertain significance Single submitter
- ANKRD46 p.Asn97Ser Uncertain significance Single submitter
- ANKRD46 p.Asp123Asn Uncertain significance Single submitter
- ANKRD46 p.Asp123Glu Uncertain significance Single submitter
- ANKRD46 p.Glu225Lys Uncertain significance Single submitter
- ANKRD46 p.Ile199Met Uncertain significance Single submitter
- ANKRD46 p.Ile21Val Uncertain significance Single submitter
- ANKRD46 p.Leu112Phe Uncertain significance Single submitter
- ANKRD46 p.Pro167Ala Uncertain significance Single submitter
- ANKRD46 p.Ser10Thr Uncertain significance Single submitter
- ANKRD46 p.Ser178Thr Uncertain significance Single submitter
- ANKRD46 p.Thr12Ala Uncertain significance Single submitter
- ANKRD46 p.Thr149Ala Uncertain significance Single submitter
- ANKRD46 p.Val14Met Uncertain significance Single submitter
- ANKRD46 p.Val220Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- ANKRD46 p.Arg117Cys Uncertain significance Single submitter
- ANKRD46 p.Arg41His Uncertain significance Single submitter
- ANKRD46 p.Arg46Lys Uncertain significance Single submitter
- ANKRD46 p.Asp59Gly Uncertain significance Single submitter
- ANKRD46 p.Asp70Asn Uncertain significance Single submitter
- ANKRD46 p.Asp89Tyr Uncertain significance Single submitter
- ANKRD46 p.Tyr212His Uncertain significance Single submitter
All ANKRD46 variants
Uncertain significance 22
- p.Arg117Cys Single submitter ⚠
- p.Arg41His Single submitter ⚠
- p.Arg46Lys Single submitter ⚠
- p.Asn166Ser Single submitter ⚠
- p.Asn97Ser Single submitter ⚠
- p.Asp123Asn Single submitter ⚠
- p.Asp123Glu Single submitter ⚠
- p.Asp59Gly Single submitter ⚠
- p.Asp70Asn Single submitter ⚠
- p.Asp89Tyr Single submitter ⚠
- p.Glu225Lys Single submitter ⚠
- p.Ile199Met Single submitter ⚠
- p.Ile21Val Single submitter ⚠
- p.Leu112Phe Single submitter ⚠
- p.Pro167Ala Single submitter ⚠
- p.Ser10Thr Single submitter ⚠
- p.Ser178Thr Single submitter ⚠
- p.Thr12Ala Single submitter ⚠
- p.Thr149Ala Single submitter ⚠
- p.Tyr212His Single submitter ⚠
- p.Val14Met Single submitter ⚠
- p.Val220Met Single submitter ⚠