ANKRD55 — 94 ClinVar variants

All ClinVar germline ANKRD55 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 82 flagged for review →

1 Benign · 1 Benign/Likely benign · 6 Likely benign · 86 Uncertain significance

Full ANKRD55 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 82

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 68

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 14

The independent predictors disagree with each other — read with care.

All ANKRD55 variants

Benign 1

p.Ala241= Multiple submitters

Benign/Likely benign 1

p.Glu279Lys Multiple submitters

Likely benign 6

p.Ser376Pro Multiple submitters
p.Arg341Gly Single submitter
p.Arg369Gln Single submitter
p.Cys351Tyr Single submitter
p.Gln158= Single submitter
p.His539= Single submitter

Uncertain significance 86

p.Ala239Glu Multiple submitters ⚠
p.Gly242Ala Multiple submitters
c.1723+1G>A Single submitter
p.Ala35Gly Single submitter ⚠
p.Ala360Thr Single submitter ⚠
p.Ala462Pro Single submitter ⚠
p.Ala467Thr Single submitter ⚠
p.Arg128Cys Single submitter ⚠
p.Arg208Lys Single submitter ⚠
p.Arg327Leu Single submitter ⚠
p.Arg342Gln Single submitter ⚠
p.Arg426Cys Single submitter ⚠
p.Arg426Ser Single submitter ⚠
p.Arg474Leu Single submitter ⚠
p.Arg48Gln Single submitter ⚠
p.Arg582Gln Single submitter ⚠
p.Arg582Trp Single submitter ⚠
p.Arg72Cys Single submitter ⚠
p.Arg72His Single submitter ⚠
p.Arg95Ser Single submitter ⚠
p.Asn126Ser Single submitter ⚠
p.Asn160Asp Single submitter ⚠
p.Asp139Asn Single submitter ⚠
p.Asp228Asn Single submitter ⚠
p.Asp399Asn Single submitter ⚠
p.Asp412Asn Single submitter ⚠
p.Asp8Glu Single submitter ⚠
p.Asp8Val Single submitter ⚠
p.Cys280Gly Single submitter ⚠
p.Cys56Ser Single submitter ⚠
p.Cys99Tyr Single submitter ⚠
p.Gln348Glu Single submitter ⚠
p.Gln348Lys Single submitter ⚠
p.Gln471Glu Single submitter ⚠
p.Glu137Gly Single submitter ⚠
p.Glu255Val Single submitter ⚠
p.Glu320Lys Single submitter ⚠
p.Glu528Gln Single submitter ⚠
p.Glu604Lys Single submitter ⚠
p.Gly220Ala Single submitter ⚠
p.Gly94Cys Single submitter ⚠
p.His177Arg Single submitter ⚠
p.His217Tyr Single submitter ⚠
p.His218Arg Single submitter ⚠
p.His555Tyr Single submitter ⚠
p.His596Arg Single submitter ⚠
p.Ile223Leu Single submitter ⚠
p.Ile247Thr Single submitter ⚠
p.Ile432Val Single submitter ⚠
p.Ile440Thr Single submitter ⚠
p.Leu142Ile Single submitter ⚠
p.Leu190Phe Single submitter ⚠
p.Leu287Val Single submitter ⚠
p.Leu520Phe Single submitter ⚠
p.Leu79Pro Single submitter ⚠
p.Lys574Asn Single submitter ⚠
p.Met30Thr Single submitter ⚠
p.Met7Arg Single submitter ⚠
p.Met7Thr Single submitter ⚠
p.Met89Val Single submitter ⚠
p.Phe350Leu Single submitter ⚠
p.Phe9Leu Single submitter ⚠
p.Pro130Ser Single submitter ⚠
p.Pro301Leu Single submitter ⚠
p.Pro328Thr Single submitter ⚠
p.Pro571Ala Single submitter ⚠
p.Ser205Arg Single submitter ⚠
p.Ser334Gly Single submitter ⚠
p.Ser436Asn Single submitter ⚠
p.Ser510Phe Single submitter ⚠
p.Ser611Arg Single submitter ⚠
p.Thr144Met Single submitter ⚠
p.Thr189Ile Single submitter
p.Thr300Met Single submitter ⚠
p.Thr311Ala Single submitter ⚠
p.Thr434Met Single submitter ⚠
p.Thr563Ala Single submitter ⚠
p.Thr63Ser Single submitter
p.Trp106Arg Single submitter ⚠
p.Tyr304Cys Single submitter ⚠
p.Val191Ala Single submitter ⚠
p.Val26Ala Single submitter ⚠
p.Val404Ala Single submitter ⚠
p.Val509Leu Single submitter ⚠
p.Val529Ala Single submitter ⚠
p.Val529Phe Single submitter ⚠