ANKRD6 — 135 ClinVar variants
All ClinVar germline ANKRD6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
12 Benign · 9 Likely benign · 114 Uncertain significance
Full ANKRD6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 83
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD6 p.Ala140Val Uncertain significance Single submitter
- ANKRD6 p.Ala182Val Uncertain significance Single submitter
- ANKRD6 p.Ala206Gly Uncertain significance Single submitter
- ANKRD6 p.Ala206Thr Uncertain significance Single submitter
- ANKRD6 p.Ala229Thr Uncertain significance Single submitter
- ANKRD6 p.Ala427Ser Uncertain significance Single submitter
- ANKRD6 p.Ala523Pro Uncertain significance Single submitter
- ANKRD6 p.Ala551Ser Uncertain significance Single submitter
- ANKRD6 p.Ala603Thr Uncertain significance Single submitter
- ANKRD6 p.Ala64Ser Uncertain significance Single submitter
- ANKRD6 p.Ala6Val Uncertain significance Single submitter
- ANKRD6 p.Ala8Thr Uncertain significance Single submitter
- ANKRD6 p.Ala93Val Uncertain significance Single submitter
- ANKRD6 p.Arg103Lys Uncertain significance Single submitter
- ANKRD6 p.Arg158His Uncertain significance Single submitter
- ANKRD6 p.Arg166His Uncertain significance Single submitter
- ANKRD6 p.Arg183Cys Uncertain significance Single submitter
- ANKRD6 p.Arg267Cys Uncertain significance Single submitter
- ANKRD6 p.Arg267His Uncertain significance Single submitter
- ANKRD6 p.Arg270Cys Uncertain significance Single submitter
- ANKRD6 p.Arg316Ile Uncertain significance Single submitter
- ANKRD6 p.Arg316Ser Uncertain significance Single submitter
- ANKRD6 p.Arg321Lys Uncertain significance Single submitter
- ANKRD6 p.Arg337Gly Uncertain significance Single submitter
- ANKRD6 p.Arg337Ser Uncertain significance Single submitter
- ANKRD6 p.Arg378Gln Uncertain significance Single submitter
- ANKRD6 p.Arg459Cys Uncertain significance Single submitter
- ANKRD6 p.Arg479His Uncertain significance Single submitter
- ANKRD6 p.Arg632Cys Uncertain significance Single submitter
- ANKRD6 p.Arg659Gln Uncertain significance Single submitter
- ANKRD6 p.Arg659Trp Uncertain significance Single submitter
- ANKRD6 p.Asn251Asp Uncertain significance Single submitter
- ANKRD6 p.Asn252Asp Uncertain significance Single submitter
- ANKRD6 p.Asn369His Uncertain significance Single submitter
- ANKRD6 p.Asn590Lys Uncertain significance Single submitter
- ANKRD6 p.Asp500Val Uncertain significance Single submitter
- ANKRD6 p.Asp553Asn Uncertain significance Single submitter
- ANKRD6 p.Asp660Asn Uncertain significance Single submitter
- ANKRD6 p.Asp67Asn Uncertain significance Single submitter
- ANKRD6 p.Cys583Tyr Uncertain significance Single submitter
- ANKRD6 p.Gln312Lys Uncertain significance Single submitter
- ANKRD6 p.Gln572Pro Uncertain significance Single submitter
- ANKRD6 p.Gln700Lys Uncertain significance Single submitter
- ANKRD6 p.Glu228Asp Uncertain significance Single submitter
- ANKRD6 p.Glu689Ala Uncertain significance Single submitter
- ANKRD6 p.Gly547Asp Uncertain significance Single submitter
- ANKRD6 p.Gly585Asp Uncertain significance Single submitter
- ANKRD6 p.His361Tyr Uncertain significance Single submitter
- ANKRD6 p.His489Arg Uncertain significance Single submitter
- ANKRD6 p.His489Gln Uncertain significance Single submitter
- ANKRD6 p.Ile189Val Uncertain significance Single submitter
- ANKRD6 p.Ile190Val Uncertain significance Single submitter
- ANKRD6 p.Ile225Met Uncertain significance Single submitter
- ANKRD6 p.Ile235Val Uncertain significance Single submitter
- ANKRD6 p.Ile30Leu Uncertain significance Single submitter
- ANKRD6 p.Ile687Thr Uncertain significance Single submitter
- ANKRD6 p.Leu135Val Uncertain significance Single submitter
- ANKRD6 p.Leu29Phe Uncertain significance Single submitter
- ANKRD6 p.Leu498Phe Uncertain significance Single submitter
- ANKRD6 p.Lys373Arg Uncertain significance Single submitter
- ANKRD6 p.Lys442Gln Uncertain significance Single submitter
- ANKRD6 p.Lys446Arg Uncertain significance Single submitter
- ANKRD6 p.Lys527Glu Uncertain significance Single submitter
- ANKRD6 p.Pro308Ser Uncertain significance Single submitter
- ANKRD6 p.Pro329Leu Uncertain significance Single submitter
- ANKRD6 p.Pro45Arg Uncertain significance Single submitter
- ANKRD6 p.Ser269Gly Uncertain significance Single submitter
- ANKRD6 p.Ser326Leu Uncertain significance Single submitter
- ANKRD6 p.Ser349Phe Uncertain significance Single submitter
- ANKRD6 p.Ser381Tyr Uncertain significance Single submitter
- ANKRD6 p.Ser531Ala Uncertain significance Single submitter
- ANKRD6 p.Ser531Phe Uncertain significance Single submitter
- ANKRD6 p.Thr209Lys Uncertain significance Single submitter
- ANKRD6 p.Thr352Ala Uncertain significance Single submitter
- ANKRD6 p.Thr454Ile Uncertain significance Single submitter
- ANKRD6 p.Thr569Ile Uncertain significance Single submitter
- ANKRD6 p.Tyr19Phe Uncertain significance Single submitter
- ANKRD6 p.Val159Ile Uncertain significance Single submitter
- ANKRD6 p.Val16Leu Uncertain significance Single submitter
- ANKRD6 p.Val180Ile Uncertain significance Single submitter
- ANKRD6 p.Val27Ile Uncertain significance Single submitter
- ANKRD6 p.Val302Ala Uncertain significance Single submitter
- ANKRD6 p.Val439Ile Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- ANKRD6 p.Ala262Val Uncertain significance Single submitter
- ANKRD6 p.Ala390Val Uncertain significance Single submitter
- ANKRD6 p.Arg248Leu Uncertain significance Single submitter
- ANKRD6 p.Arg398Gln Uncertain significance Single submitter
- ANKRD6 p.Arg398Trp Uncertain significance Single submitter
- ANKRD6 p.Arg413Gln Uncertain significance Single submitter
- ANKRD6 p.Arg43Gln Uncertain significance Single submitter
- ANKRD6 p.Arg81Gln Uncertain significance Single submitter
- ANKRD6 p.Arg81Leu Uncertain significance Single submitter
- ANKRD6 p.Asn171Asp Uncertain significance Single submitter
- ANKRD6 p.Gly108Glu Uncertain significance Single submitter
- ANKRD6 p.His153Tyr Uncertain significance Single submitter
- ANKRD6 p.Ile432Lys Uncertain significance Single submitter
- ANKRD6 p.Leu147Val Uncertain significance Single submitter
- ANKRD6 p.Leu192Phe Uncertain significance Single submitter
- ANKRD6 p.Leu258Phe Uncertain significance Single submitter
- ANKRD6 p.Lys32Asn Uncertain significance Single submitter
- ANKRD6 p.Ser121Arg Uncertain significance Single submitter
- ANKRD6 p.Ser152Arg Uncertain significance Single submitter
- ANKRD6 p.Thr77Ser Uncertain significance Single submitter
- ANKRD6 p.Tyr391His Uncertain significance Single submitter
All ANKRD6 variants
Benign 12
- p.Lys702= Single submitter
- p.Met458Leu Single submitter
- p.Pro636= Single submitter
- p.Ser123= Single submitter
- p.Ala347= No assertion criteria ANKRD6-related disorder
- p.Ala550Thr No assertion criteria ANKRD6-related disorder
- p.Cys506= No assertion criteria ANKRD6-related disorder
- p.Gln122Glu No assertion criteria ANKRD6-related disorder
- p.Ile128Val No assertion criteria ANKRD6-related disorder
- p.Pro636Leu No assertion criteria ANKRD6-related disorder
- p.Ser579= No assertion criteria ANKRD6-related disorder
- p.Thr233Met No assertion criteria ANKRD6-related disorder
Likely benign 9
- p.Ala182= Single submitter
- p.Ala229= Single submitter
- p.Ala637Thr Single submitter
- p.Arg722Lys Single submitter
- p.Ser639Gly Single submitter
- p.Val213Ile Single submitter
- c.1486-5_1486-4dup No assertion criteria ANKRD6-related disorder
- p.Leu127= No assertion criteria ANKRD6-related disorder
- p.Thr157= No assertion criteria ANKRD6-related disorder
Uncertain significance 114
- p.Ala140Val Single submitter ⚠
- p.Ala173Glu Single submitter
- p.Ala182Val Single submitter ⚠
- p.Ala206Gly Single submitter ⚠
- p.Ala206Thr Single submitter ⚠
- p.Ala229Thr Single submitter ⚠
- p.Ala262Val Single submitter ⚠
- p.Ala390Ser Single submitter
- p.Ala390Val Single submitter ⚠
- p.Ala427Ser Single submitter ⚠
- p.Ala523Pro Single submitter ⚠
- p.Ala551Ser Single submitter ⚠
- p.Ala603Thr Single submitter ⚠
- p.Ala64Ser Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Ala8Thr Single submitter ⚠
- p.Ala93Val Single submitter ⚠
- p.Arg103Lys Single submitter ⚠
- p.Arg158Cys Single submitter
- p.Arg158His Single submitter ⚠
- p.Arg166Cys Single submitter
- p.Arg166His Single submitter ⚠
- p.Arg183Cys Single submitter ⚠
- p.Arg248Cys Single submitter
- p.Arg248His Single submitter
- p.Arg248Leu Single submitter ⚠
- p.Arg267Cys Single submitter ⚠
- p.Arg267His Single submitter ⚠
- p.Arg270Cys Single submitter ⚠
- p.Arg316Ile Single submitter ⚠
- p.Arg316Ser Single submitter ⚠
- p.Arg321Lys Single submitter ⚠
- p.Arg337Gly Single submitter ⚠
- p.Arg337Ser Single submitter ⚠
- p.Arg378Gln Single submitter ⚠
- p.Arg398Gln Single submitter ⚠
- p.Arg398Trp Single submitter ⚠
- p.Arg413Gln Single submitter ⚠
- p.Arg43Gln Single submitter ⚠
- p.Arg459Cys Single submitter ⚠
- p.Arg479His Single submitter ⚠
- p.Arg632Cys Single submitter ⚠
- p.Arg659Gln Single submitter ⚠
- p.Arg659Trp Single submitter ⚠
- p.Arg81Gln Single submitter ⚠
- p.Arg81Leu Single submitter ⚠
- p.Asn171Asp Single submitter ⚠
- p.Asn251Asp Single submitter ⚠
- p.Asn252Asp Single submitter ⚠
- p.Asn369His Single submitter ⚠
- p.Asn590Lys Single submitter ⚠
- p.Asp500Val Single submitter ⚠
- p.Asp553Asn Single submitter ⚠
- p.Asp660Asn Single submitter ⚠
- p.Asp67Asn Single submitter ⚠
- p.Cys583Tyr Single submitter ⚠
- p.Gln312Lys Single submitter ⚠
- p.Gln572Pro Single submitter ⚠
- p.Gln700Lys Single submitter ⚠
- p.Glu228Asp Single submitter ⚠
- p.Glu689Ala Single submitter ⚠
- p.Gly108Glu Single submitter ⚠
- p.Gly547Asp Single submitter ⚠
- p.Gly585Asp Single submitter ⚠
- p.His153Tyr Single submitter ⚠
- p.His361Tyr Single submitter ⚠
- p.His489Arg Single submitter ⚠
- p.His489Gln Single submitter ⚠
- p.Ile189Val Single submitter ⚠
- p.Ile190Val Single submitter ⚠
- p.Ile225Met Single submitter ⚠
- p.Ile235Val Single submitter ⚠
- p.Ile30Leu Single submitter ⚠
- p.Ile432Lys Single submitter ⚠
- p.Ile687Thr Single submitter ⚠
- p.Leu135Val Single submitter ⚠
- p.Leu147Val Single submitter ⚠
- p.Leu187Trp Single submitter
- p.Leu192Phe Single submitter ⚠
- p.Leu258Phe Single submitter ⚠
- p.Leu29Phe Single submitter ⚠
- p.Leu498Phe Single submitter ⚠
- p.Lys32Asn Single submitter ⚠
- p.Lys373Arg Single submitter ⚠
- p.Lys442Gln Single submitter ⚠
- p.Lys446Arg Single submitter ⚠
- p.Lys527Asn Single submitter
- p.Lys527Glu Single submitter ⚠
- p.Pro253Arg Single submitter
- p.Pro308Ser Single submitter ⚠
- p.Pro329Leu Single submitter ⚠
- p.Pro45Arg Single submitter ⚠
- p.Ser121Arg Single submitter ⚠
- p.Ser152Arg Single submitter ⚠
- p.Ser269Gly Single submitter ⚠
- p.Ser326Leu Single submitter ⚠
- p.Ser349Phe Single submitter ⚠
- p.Ser381Tyr Single submitter ⚠
- p.Ser531Ala Single submitter ⚠
- p.Ser531Phe Single submitter ⚠
- p.Thr176Asn Single submitter
- p.Thr209Lys Single submitter ⚠
- p.Thr352Ala Single submitter ⚠
- p.Thr454Ile Single submitter ⚠
- p.Thr569Ile Single submitter ⚠
- p.Thr77Ser Single submitter ⚠
- p.Tyr19Phe Single submitter ⚠
- p.Tyr391His Single submitter ⚠
- p.Val159Ile Single submitter ⚠
- p.Val16Leu Single submitter ⚠
- p.Val180Ile Single submitter ⚠
- p.Val27Ile Single submitter ⚠
- p.Val302Ala Single submitter ⚠
- p.Val439Ile Single submitter ⚠