ANKRD63 — 52 ClinVar variants
All ClinVar germline ANKRD63 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
1 Likely benign · 51 Uncertain significance
Full ANKRD63 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD63 p.Ala163Thr Uncertain significance Single submitter
- ANKRD63 p.Ala182Thr Uncertain significance Single submitter
- ANKRD63 p.Ala201Glu Uncertain significance Single submitter
- ANKRD63 p.Ala201Thr Uncertain significance Single submitter
- ANKRD63 p.Ala226Thr Uncertain significance Single submitter
- ANKRD63 p.Ala236Thr Uncertain significance Single submitter
- ANKRD63 p.Ala269Val Uncertain significance Single submitter
- ANKRD63 p.Ala276Ser Uncertain significance Single submitter
- ANKRD63 p.Ala308Val Uncertain significance Single submitter
- ANKRD63 p.Ala356Val Uncertain significance Single submitter
- ANKRD63 p.Ala99Val Uncertain significance Single submitter
- ANKRD63 p.Arg138Gln Uncertain significance Single submitter
- ANKRD63 p.Arg152Leu Uncertain significance Single submitter
- ANKRD63 p.Arg212Cys Uncertain significance Single submitter
- ANKRD63 p.Arg221His Uncertain significance Single submitter
- ANKRD63 p.Arg244Gly Uncertain significance Single submitter
- ANKRD63 p.Arg244Pro Uncertain significance Single submitter
- ANKRD63 p.Arg255Trp Uncertain significance Single submitter
- ANKRD63 p.Arg271Cys Uncertain significance Single submitter
- ANKRD63 p.Arg273Gln Uncertain significance Single submitter
- ANKRD63 p.Arg328Gly Uncertain significance Single submitter
- ANKRD63 p.Gln368Arg Uncertain significance Single submitter
- ANKRD63 p.Glu205Lys Uncertain significance Single submitter
- ANKRD63 p.Glu317Gly Uncertain significance Single submitter
- ANKRD63 p.Gly241Ser Uncertain significance Single submitter
- ANKRD63 p.Gly321Ser Uncertain significance Single submitter
- ANKRD63 p.Gly326Asp Uncertain significance Single submitter
- ANKRD63 p.Leu272Pro Uncertain significance Single submitter
- ANKRD63 p.Leu280Gln Uncertain significance Single submitter
- ANKRD63 p.Leu305Ser Uncertain significance Single submitter
- ANKRD63 p.Leu339Val Uncertain significance Single submitter
- ANKRD63 p.Leu357Met Uncertain significance Single submitter
- ANKRD63 p.Pro194Thr Uncertain significance Single submitter
- ANKRD63 p.Pro204Arg Uncertain significance Single submitter
- ANKRD63 p.Pro251Ser Uncertain significance Single submitter
- ANKRD63 p.Pro251Thr Uncertain significance Single submitter
- ANKRD63 p.Pro284Ser Uncertain significance Single submitter
- ANKRD63 p.Pro316Arg Uncertain significance Single submitter
- ANKRD63 p.Pro316Leu Uncertain significance Single submitter
- ANKRD63 p.Ser189Pro Uncertain significance Single submitter
- ANKRD63 p.Ser203Asn Uncertain significance Single submitter
- ANKRD63 p.Ser283Pro Uncertain significance Single submitter
- ANKRD63 p.Ser287Leu Uncertain significance Single submitter
- ANKRD63 p.Ser294Pro Uncertain significance Single submitter
- ANKRD63 p.Ser338Thr Uncertain significance Single submitter
- ANKRD63 p.Ser360Trp Uncertain significance Single submitter
- ANKRD63 p.Val297Leu Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All ANKRD63 variants
Likely benign 1
- p.Asn365Lys Single submitter
Uncertain significance 51
- p.Ala163Thr Single submitter ⚠
- p.Ala182Thr Single submitter ⚠
- p.Ala201Glu Single submitter ⚠
- p.Ala201Thr Single submitter ⚠
- p.Ala226Thr Single submitter ⚠
- p.Ala236Thr Single submitter ⚠
- p.Ala269Val Single submitter ⚠
- p.Ala276Ser Single submitter ⚠
- p.Ala308Val Single submitter ⚠
- p.Ala356Val Single submitter ⚠
- p.Ala99Val Single submitter ⚠
- p.Arg138Gln Single submitter ⚠
- p.Arg152Leu Single submitter ⚠
- p.Arg212Cys Single submitter ⚠
- p.Arg221His Single submitter ⚠
- p.Arg244Gly Single submitter ⚠
- p.Arg244Pro Single submitter ⚠
- p.Arg255Trp Single submitter ⚠
- p.Arg271Cys Single submitter ⚠
- p.Arg273Gln Single submitter ⚠
- p.Arg328Gly Single submitter ⚠
- p.Gln368Arg Single submitter ⚠
- p.Glu205Lys Single submitter ⚠
- p.Glu317Gly Single submitter ⚠
- p.Gly241Ser Single submitter ⚠
- p.Gly321Ser Single submitter ⚠
- p.Gly326Asp Single submitter ⚠
- p.Ile336Ser Single submitter ⚠
- p.Leu272Pro Single submitter ⚠
- p.Leu280Gln Single submitter ⚠
- p.Leu305Ser Single submitter ⚠
- p.Leu339Val Single submitter ⚠
- p.Leu357Met Single submitter ⚠
- p.Met122Ile Single submitter ⚠
- p.Pro194Thr Single submitter ⚠
- p.Pro204Arg Single submitter ⚠
- p.Pro251Ser Single submitter ⚠
- p.Pro251Thr Single submitter ⚠
- p.Pro284Ser Single submitter ⚠
- p.Pro316Arg Single submitter ⚠
- p.Pro316Leu Single submitter ⚠
- p.Pro4His Single submitter ⚠
- p.Ser189Pro Single submitter ⚠
- p.Ser203Asn Single submitter ⚠
- p.Ser283Pro Single submitter ⚠
- p.Ser287Leu Single submitter ⚠
- p.Ser294Pro Single submitter ⚠
- p.Ser338Thr Single submitter ⚠
- p.Ser360Trp Single submitter ⚠
- p.Val297Leu Single submitter ⚠
- p.Val67Met Single submitter ⚠