ANKRD65 — 107 ClinVar variants
All ClinVar germline ANKRD65 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →
11 Likely benign · 96 Uncertain significance
Full ANKRD65 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 89
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD65 p.Ala106Val Uncertain significance Single submitter
- ANKRD65 p.Ala147Asp Uncertain significance Single submitter
- ANKRD65 p.Ala168Thr Uncertain significance Single submitter
- ANKRD65 p.Ala170Val Uncertain significance Single submitter
- ANKRD65 p.Ala198Ser Uncertain significance Single submitter
- ANKRD65 p.Ala201Thr Uncertain significance Single submitter
- ANKRD65 p.Ala211Ser Uncertain significance Single submitter
- ANKRD65 p.Ala218Thr Uncertain significance Single submitter
- ANKRD65 p.Ala239Ser Uncertain significance Single submitter
- ANKRD65 p.Ala65Val Uncertain significance Single submitter
- ANKRD65 p.Ala87Thr Uncertain significance Single submitter
- ANKRD65 p.Ala98Ser Uncertain significance Single submitter
- ANKRD65 p.Arg105Gln Uncertain significance Single submitter
- ANKRD65 p.Arg108Pro Uncertain significance Single submitter
- ANKRD65 p.Arg220Gly Uncertain significance Single submitter
- ANKRD65 p.Arg220His Uncertain significance Single submitter
- ANKRD65 p.Arg225Ser Uncertain significance Single submitter
- ANKRD65 p.Arg248Gly Uncertain significance Single submitter
- ANKRD65 p.Arg270Cys Uncertain significance Single submitter
- ANKRD65 p.Arg311Gln Uncertain significance Single submitter
- ANKRD65 p.Arg311Trp Uncertain significance Single submitter
- ANKRD65 p.Arg324Ser Uncertain significance Single submitter
- ANKRD65 p.Arg345Gln Uncertain significance Single submitter
- ANKRD65 p.Arg364Gln Uncertain significance Single submitter
- ANKRD65 p.Arg51Lys Uncertain significance Single submitter
- ANKRD65 p.Arg62Trp Uncertain significance Single submitter
- ANKRD65 p.Arg70Ser Uncertain significance Single submitter
- ANKRD65 p.Arg75Gln Uncertain significance Single submitter
- ANKRD65 p.Arg75Pro Uncertain significance Single submitter
- ANKRD65 p.Arg84Gln Uncertain significance Single submitter
- ANKRD65 p.Arg84Pro Uncertain significance Single submitter
- ANKRD65 p.Arg91Pro Uncertain significance Single submitter
- ANKRD65 p.Arg96Gln Uncertain significance Single submitter
- ANKRD65 p.Arg9Thr Uncertain significance Single submitter
- ANKRD65 p.Asp204Gly Uncertain significance Single submitter
- ANKRD65 p.Gln291Arg Uncertain significance Single submitter
- ANKRD65 p.Glu396Val Uncertain significance Single submitter
- ANKRD65 p.Gly138Arg Uncertain significance Single submitter
- ANKRD65 p.Gly138Glu Uncertain significance Single submitter
- ANKRD65 p.Gly188Glu Uncertain significance Single submitter
- ANKRD65 p.Gly241Asp Uncertain significance Single submitter
- ANKRD65 p.Gly280Glu Uncertain significance Single submitter
- ANKRD65 p.Gly30Arg Uncertain significance Single submitter
- ANKRD65 p.Gly332Ser Uncertain significance Single submitter
- ANKRD65 p.Gly35Arg Uncertain significance Single submitter
- ANKRD65 p.Gly387Ala Uncertain significance Single submitter
- ANKRD65 p.Gly387Arg Uncertain significance Single submitter
- ANKRD65 p.Gly387Trp Uncertain significance Single submitter
- ANKRD65 p.Gly387Val Uncertain significance Single submitter
- ANKRD65 p.Gly43Arg Uncertain significance Single submitter
- ANKRD65 p.His44Gln Uncertain significance Single submitter
- ANKRD65 p.Ile252Thr Uncertain significance Single submitter
- ANKRD65 p.Leu160Met Uncertain significance Single submitter
- ANKRD65 p.Leu288Pro Uncertain significance Single submitter
- ANKRD65 p.Leu89Pro Uncertain significance Single submitter
- ANKRD65 p.Leu93Arg Uncertain significance Single submitter
- ANKRD65 p.Leu93Met Uncertain significance Single submitter
- ANKRD65 p.Pro167Leu Uncertain significance Single submitter
- ANKRD65 p.Pro36Ser Uncertain significance Single submitter
- ANKRD65 p.Pro383Ser Uncertain significance Single submitter
- ANKRD65 p.Pro77Ala Uncertain significance Single submitter
- ANKRD65 p.Pro77Arg Uncertain significance Single submitter
- ANKRD65 p.Ser3Thr Uncertain significance Single submitter
- ANKRD65 p.Thr238Ile Uncertain significance Single submitter
- ANKRD65 p.Thr398Met Uncertain significance Single submitter
- ANKRD65 p.Val82Leu Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- ANKRD65 p.Ala115Thr Uncertain significance Single submitter
- ANKRD65 p.Ala162Pro Uncertain significance Single submitter
- ANKRD65 p.Ala180Val Uncertain significance Single submitter
- ANKRD65 p.Ala272Glu Uncertain significance Single submitter
- ANKRD65 p.Ala272Val Uncertain significance Single submitter
- ANKRD65 p.Ala278Thr Uncertain significance Single submitter
- ANKRD65 p.Arg158Pro Uncertain significance Single submitter
- ANKRD65 p.Arg298Trp Uncertain significance Single submitter
- ANKRD65 p.Arg357Gln Uncertain significance Single submitter
- ANKRD65 p.Arg357Gly Uncertain significance Single submitter
- ANKRD65 p.Asp71Asn Uncertain significance Single submitter
- ANKRD65 p.Gly140Val Uncertain significance Single submitter
- ANKRD65 p.Gly205Cys Uncertain significance Single submitter
- ANKRD65 p.Gly226Ala Uncertain significance Single submitter
- ANKRD65 p.Gly226Arg Uncertain significance Single submitter
- ANKRD65 p.Gly259Arg Uncertain significance Single submitter
- ANKRD65 p.Gly263Asp Uncertain significance Single submitter
- ANKRD65 p.Gly346Trp Uncertain significance Single submitter
- ANKRD65 p.Pro163Ala Uncertain significance Single submitter
- ANKRD65 p.Pro163Leu Uncertain significance Single submitter
- ANKRD65 p.Trp116Arg Uncertain significance Single submitter
- ANKRD65 p.Trp42Arg Uncertain significance Single submitter
- ANKRD65 p.Val285Ile Uncertain significance Single submitter
All ANKRD65 variants
Likely benign 11
- p.Ala243= Single submitter
- p.Ala284= Single submitter
- p.Ala381Val Single submitter
- p.Arg19Gln Single submitter
- p.Arg298Gln Single submitter
- p.Arg84= Single submitter
- p.Glu26Lys Single submitter
- p.Glu294Lys Single submitter
- p.Gly319Ser Single submitter
- p.Leu321= Single submitter
- p.Leu46= Single submitter
Uncertain significance 96
- p.Ala106Val Single submitter ⚠
- p.Ala115Thr Single submitter ⚠
- p.Ala147Asp Single submitter ⚠
- p.Ala162Pro Single submitter ⚠
- p.Ala168Thr Single submitter ⚠
- p.Ala170Val Single submitter ⚠
- p.Ala180Val Single submitter ⚠
- p.Ala198Ser Single submitter ⚠
- p.Ala201Thr Single submitter ⚠
- p.Ala211Ser Single submitter ⚠
- p.Ala218Thr Single submitter ⚠
- p.Ala239Ser Single submitter ⚠
- p.Ala272Glu Single submitter ⚠
- p.Ala272Val Single submitter ⚠
- p.Ala278Thr Single submitter ⚠
- p.Ala65Val Single submitter ⚠
- p.Ala87Thr Single submitter ⚠
- p.Ala98Ser Single submitter ⚠
- p.Arg105Gln Single submitter ⚠
- p.Arg108Pro Single submitter ⚠
- p.Arg158Pro Single submitter ⚠
- p.Arg220Gly Single submitter ⚠
- p.Arg220His Single submitter ⚠
- p.Arg225Ser Single submitter ⚠
- p.Arg248Gly Single submitter ⚠
- p.Arg270Cys Single submitter ⚠
- p.Arg298Trp Single submitter ⚠
- p.Arg311Gln Single submitter ⚠
- p.Arg311Trp Single submitter ⚠
- p.Arg324Ser Single submitter ⚠
- p.Arg345Gln Single submitter ⚠
- p.Arg357Gln Single submitter ⚠
- p.Arg357Gly Single submitter ⚠
- p.Arg364Gln Single submitter ⚠
- p.Arg51Lys Single submitter ⚠
- p.Arg62Trp Single submitter ⚠
- p.Arg70Ser Single submitter ⚠
- p.Arg75Gln Single submitter ⚠
- p.Arg75Pro Single submitter ⚠
- p.Arg84Gln Single submitter ⚠
- p.Arg84Pro Single submitter ⚠
- p.Arg91Pro Single submitter ⚠
- p.Arg96Gln Single submitter ⚠
- p.Arg9Thr Single submitter ⚠
- p.Asp204Gly Single submitter ⚠
- p.Asp71Asn Single submitter ⚠
- p.Gln291Arg Single submitter ⚠
- p.Glu396Val Single submitter ⚠
- p.Gly138Arg Single submitter ⚠
- p.Gly138Glu Single submitter ⚠
- p.Gly140Val Single submitter ⚠
- p.Gly188Glu Single submitter ⚠
- p.Gly205Cys Single submitter ⚠
- p.Gly226Ala Single submitter ⚠
- p.Gly226Arg Single submitter ⚠
- p.Gly241Asp Single submitter ⚠
- p.Gly259Ala Single submitter
- p.Gly259Arg Single submitter ⚠
- p.Gly263Asp Single submitter ⚠
- p.Gly280Glu Single submitter ⚠
- p.Gly30Arg Single submitter ⚠
- p.Gly332Ser Single submitter ⚠
- p.Gly346Trp Single submitter ⚠
- p.Gly35Arg Single submitter ⚠
- p.Gly387Ala Single submitter ⚠
- p.Gly387Arg Single submitter ⚠
- p.Gly387Trp Single submitter ⚠
- p.Gly387Val Single submitter ⚠
- p.Gly43Arg Single submitter ⚠
- p.Gly64Ser Single submitter
- p.Gly74Ser Single submitter
- p.Gly97Arg Single submitter
- p.His44Gln Single submitter ⚠
- p.Ile252Thr Single submitter ⚠
- p.Leu155Pro Single submitter
- p.Leu160Met Single submitter ⚠
- p.Leu240Met Single submitter
- p.Leu288Pro Single submitter ⚠
- p.Leu89Pro Single submitter ⚠
- p.Leu93Arg Single submitter ⚠
- p.Leu93Met Single submitter ⚠
- p.Pro163Ala Single submitter ⚠
- p.Pro163Leu Single submitter ⚠
- p.Pro167Leu Single submitter ⚠
- p.Pro36Ser Single submitter ⚠
- p.Pro383Ser Single submitter ⚠
- p.Pro77Ala Single submitter ⚠
- p.Pro77Arg Single submitter ⚠
- p.Ser3Thr Single submitter ⚠
- p.Thr142Arg Single submitter
- p.Thr238Ile Single submitter ⚠
- p.Thr398Met Single submitter ⚠
- p.Trp116Arg Single submitter ⚠
- p.Trp42Arg Single submitter ⚠
- p.Val285Ile Single submitter ⚠
- p.Val82Leu Single submitter ⚠