ANKRD66 — 51 ClinVar variants
All ClinVar germline ANKRD66 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 1 flagged for review →
3 Likely benign · 48 Uncertain significance
Full ANKRD66 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 1
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 1
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All ANKRD66 variants
Likely benign 3
- c.-150C>T Single submitter
- p.Arg45Gln Single submitter
- p.Ile92Val Single submitter
Uncertain significance 48
- c.4G>T Single submitter
- c.-29C>A Single submitter
- c.-35C>T Single submitter
- c.-39G>A Single submitter
- c.-69C>T Single submitter
- c.-75C>T Single submitter
- c.-95G>T Single submitter
- p.Ala101Thr Single submitter
- p.Ala117Ser Single submitter
- p.Ala124Gly Single submitter
- p.Ala124Ser Single submitter
- p.Ala68Gly Single submitter
- p.Arg153His Single submitter
- p.Arg195Gly Single submitter
- p.Arg61Leu Single submitter
- p.Arg61Trp Single submitter
- p.Asn172Lys Single submitter
- p.Asn179Lys Single submitter
- p.Asn36Ser Single submitter ⚠
- p.Asn43Asp Single submitter
- p.Asp156Asn Single submitter
- p.Asp158Asn Single submitter
- p.Cys136Arg Single submitter
- p.Cys141Tyr Single submitter
- p.Cys71Arg Single submitter
- p.Gln145Arg Single submitter
- p.Glu152Ala Single submitter
- p.Gly184Val Single submitter
- p.Ile60Thr Single submitter
- p.Ile60Val Single submitter
- p.Leu129Gln Single submitter
- p.Leu150Pro Single submitter
- p.Leu164Val Single submitter
- p.Leu166Met Single submitter
- p.Leu48Pro Single submitter
- p.Lys26Gln Single submitter
- p.Met6Ile Single submitter
- p.Met9Lys Single submitter
- p.Pro113Leu Single submitter
- p.Pro185Ser Single submitter
- p.Ser182Arg Single submitter
- p.Ser75Asn Single submitter
- p.Thr79Asn Single submitter
- p.Thr95Ala Single submitter
- p.Tyr120Cys Single submitter
- p.Tyr21Asn Single submitter
- p.Val16Met Single submitter
- p.Val40Ile Single submitter