ANKRD7 — 34 ClinVar variants
All ClinVar germline ANKRD7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
2 Likely benign · 32 Uncertain significance
Full ANKRD7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKRD7 p.Arg124Cys Uncertain significance Single submitter
- ANKRD7 p.Arg124His Uncertain significance Single submitter
- ANKRD7 p.Arg22Gln Uncertain significance Single submitter
- ANKRD7 p.Arg22Pro Uncertain significance Single submitter
- ANKRD7 p.Asn20Lys Uncertain significance Single submitter
- ANKRD7 p.Gln17Lys Uncertain significance Single submitter
- ANKRD7 p.Glu216Gly Uncertain significance Single submitter
- ANKRD7 p.Glu80Asp Uncertain significance Single submitter
- ANKRD7 p.Gly248Arg Uncertain significance Single submitter
- ANKRD7 p.Leu129Arg Uncertain significance Single submitter
- ANKRD7 p.Leu26Val Uncertain significance Single submitter
- ANKRD7 p.Lys24Gln Uncertain significance Single submitter
- ANKRD7 p.Met234Thr Uncertain significance Single submitter
- ANKRD7 p.Met54Ile Uncertain significance Single submitter
- ANKRD7 p.Met54Thr Uncertain significance Single submitter
- ANKRD7 p.Pro204Ser Uncertain significance Single submitter
- ANKRD7 p.Ser16Asn Uncertain significance Single submitter
- ANKRD7 p.Thr61Ile Uncertain significance Single submitter
- ANKRD7 p.Tyr219Asp Uncertain significance Single submitter
- ANKRD7 p.Val223Gly Uncertain significance Single submitter
- ANKRD7 p.Val235Phe Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- ANKRD7 p.Ala68Thr Uncertain significance Single submitter
- ANKRD7 p.Ala99Ser Uncertain significance Single submitter
- ANKRD7 p.Asp117Asn Uncertain significance Single submitter
- ANKRD7 p.Glu146Val Uncertain significance Single submitter
- ANKRD7 p.Glu179Val Uncertain significance Single submitter
- ANKRD7 p.Leu227Met Uncertain significance Single submitter
- ANKRD7 p.Leu45Phe Uncertain significance Single submitter
- ANKRD7 p.Met173Val Uncertain significance Single submitter
- ANKRD7 p.Ser6Arg Uncertain significance Single submitter
- ANKRD7 p.Val184Leu Uncertain significance Single submitter
- ANKRD7 p.Val184Met Uncertain significance Single submitter
All ANKRD7 variants
Likely benign 2
- p.Glu148Lys Single submitter
- p.Val223Met Single submitter
Uncertain significance 32
- p.Ala68Thr Single submitter ⚠
- p.Ala99Ser Single submitter ⚠
- p.Arg124Cys Single submitter ⚠
- p.Arg124His Single submitter ⚠
- p.Arg22Gln Single submitter ⚠
- p.Arg22Pro Single submitter ⚠
- p.Asn20Lys Single submitter ⚠
- p.Asp117Asn Single submitter ⚠
- p.Gln17Lys Single submitter ⚠
- p.Glu146Val Single submitter ⚠
- p.Glu179Val Single submitter ⚠
- p.Glu216Gly Single submitter ⚠
- p.Glu80Asp Single submitter ⚠
- p.Gly248Arg Single submitter ⚠
- p.Leu129Arg Single submitter ⚠
- p.Leu227Met Single submitter ⚠
- p.Leu26Val Single submitter ⚠
- p.Leu45Phe Single submitter ⚠
- p.Lys24Gln Single submitter ⚠
- p.Met173Val Single submitter ⚠
- p.Met234Thr Single submitter ⚠
- p.Met54Ile Single submitter ⚠
- p.Met54Thr Single submitter ⚠
- p.Pro204Ser Single submitter ⚠
- p.Ser16Asn Single submitter ⚠
- p.Ser6Arg Single submitter ⚠
- p.Thr61Ile Single submitter ⚠
- p.Tyr219Asp Single submitter ⚠
- p.Val184Leu Single submitter ⚠
- p.Val184Met Single submitter ⚠
- p.Val223Gly Single submitter ⚠
- p.Val235Phe Single submitter ⚠