ANKUB1 — 80 ClinVar variants
All ClinVar germline ANKUB1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
6 Likely benign · 74 Uncertain significance
Full ANKUB1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANKUB1 p.Ala195Ser Uncertain significance Single submitter
- ANKUB1 p.Ala365Ser Uncertain significance Single submitter
- ANKUB1 p.Ala413Ser Uncertain significance Single submitter
- ANKUB1 p.Ala494Val Uncertain significance Single submitter
- ANKUB1 p.Ala55Ser Uncertain significance Single submitter
- ANKUB1 p.Arg155Cys Uncertain significance Single submitter
- ANKUB1 p.Arg155His Uncertain significance Single submitter
- ANKUB1 p.Arg179Cys Uncertain significance Single submitter
- ANKUB1 p.Arg179His Uncertain significance Single submitter
- ANKUB1 p.Arg228Gln Uncertain significance Single submitter
- ANKUB1 p.Arg45Gln Uncertain significance Single submitter
- ANKUB1 p.Asn367Lys Uncertain significance Single submitter
- ANKUB1 p.Asn443Thr Uncertain significance Single submitter
- ANKUB1 p.Asp350Gly Uncertain significance Single submitter
- ANKUB1 p.Cys334Tyr Uncertain significance Single submitter
- ANKUB1 p.Gln275Arg Uncertain significance Single submitter
- ANKUB1 p.Gln420Glu Uncertain significance Single submitter
- ANKUB1 p.Gln448Glu Uncertain significance Single submitter
- ANKUB1 p.Glu20Lys Uncertain significance Single submitter
- ANKUB1 p.Gly203Val Uncertain significance Single submitter
- ANKUB1 p.Gly223Ser Uncertain significance Single submitter
- ANKUB1 p.Gly274Arg Uncertain significance Single submitter
- ANKUB1 p.His326Tyr Uncertain significance Single submitter
- ANKUB1 p.His363Gln Uncertain significance Single submitter
- ANKUB1 p.His461Arg Uncertain significance Single submitter
- ANKUB1 p.His461Tyr Uncertain significance Single submitter
- ANKUB1 p.Ile306Leu Uncertain significance Single submitter
- ANKUB1 p.Ile430Asn Uncertain significance Single submitter
- ANKUB1 p.Leu196Gln Uncertain significance Single submitter
- ANKUB1 p.Leu474Val Uncertain significance Single submitter
- ANKUB1 p.Leu62Pro Uncertain significance Single submitter
- ANKUB1 p.Lys176Glu Uncertain significance Single submitter
- ANKUB1 p.Lys189Glu Uncertain significance Single submitter
- ANKUB1 p.Lys213Asn Uncertain significance Single submitter
- ANKUB1 p.Lys437Asn Uncertain significance Single submitter
- ANKUB1 p.Met310Val Uncertain significance Single submitter
- ANKUB1 p.Phe465Ser Uncertain significance Single submitter
- ANKUB1 p.Pro123Arg Uncertain significance Single submitter
- ANKUB1 p.Pro186Gln Uncertain significance Single submitter
- ANKUB1 p.Pro355Leu Uncertain significance Single submitter
- ANKUB1 p.Pro450Leu Uncertain significance Single submitter
- ANKUB1 p.Pro452Arg Uncertain significance Single submitter
- ANKUB1 p.Pro452Ser Uncertain significance Single submitter
- ANKUB1 p.Pro462Gln Uncertain significance Single submitter
- ANKUB1 p.Ser10Ala Uncertain significance Single submitter
- ANKUB1 p.Thr276Ala Uncertain significance Single submitter
- ANKUB1 p.Thr84Asn Uncertain significance Single submitter
- ANKUB1 p.Trp298Cys Uncertain significance Single submitter
- ANKUB1 p.Tyr138His Uncertain significance Single submitter
- ANKUB1 p.Tyr496Cys Uncertain significance Single submitter
- ANKUB1 p.Tyr86His Uncertain significance Single submitter
- ANKUB1 p.Val126Ile Uncertain significance Single submitter
- ANKUB1 p.Val158Ile Uncertain significance Single submitter
- ANKUB1 p.Val374Met Uncertain significance Single submitter
- ANKUB1 p.Val449Ile Uncertain significance Single submitter
- ANKUB1 p.Val457Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- ANKUB1 p.Ala248Thr Uncertain significance Single submitter
- ANKUB1 p.Asn89Ser Uncertain significance Single submitter
- ANKUB1 p.Asp58Ala Uncertain significance Single submitter
- ANKUB1 p.Asp58His Uncertain significance Single submitter
- ANKUB1 p.Cys231Tyr Uncertain significance Single submitter
- ANKUB1 p.Gln318Pro Uncertain significance Single submitter
- ANKUB1 p.Ile316Arg Uncertain significance Single submitter
- ANKUB1 p.Met137Thr Uncertain significance Single submitter
- ANKUB1 p.Trp60Gly Uncertain significance Single submitter
- ANKUB1 p.Tyr127Ser Uncertain significance Single submitter
- ANKUB1 p.Val177Leu Uncertain significance Single submitter
All ANKUB1 variants
Likely benign 6
- p.Ala6Thr Single submitter
- p.Asn391Ser Single submitter
- p.Gly335Arg Single submitter
- p.Phe333Leu Single submitter
- p.Ser327Asn Single submitter
- p.Val374Leu Single submitter
Uncertain significance 74
- p.Ala195Ser Single submitter ⚠
- p.Ala248Thr Single submitter ⚠
- p.Ala365Ser Single submitter ⚠
- p.Ala413Ser Single submitter ⚠
- p.Ala494Val Single submitter ⚠
- p.Ala55Ser Single submitter ⚠
- p.Arg155Cys Single submitter ⚠
- p.Arg155His Single submitter ⚠
- p.Arg179Cys Single submitter ⚠
- p.Arg179His Single submitter ⚠
- p.Arg228Gln Single submitter ⚠
- p.Arg45Gln Single submitter ⚠
- p.Asn367Lys Single submitter ⚠
- p.Asn443Thr Single submitter ⚠
- p.Asn89Ser Single submitter ⚠
- p.Asp350Gly Single submitter ⚠
- p.Asp58Ala Single submitter ⚠
- p.Asp58His Single submitter ⚠
- p.Cys231Tyr Single submitter ⚠
- p.Cys334Tyr Single submitter ⚠
- p.Gln275Arg Single submitter ⚠
- p.Gln318Pro Single submitter ⚠
- p.Gln420Glu Single submitter ⚠
- p.Gln448Glu Single submitter ⚠
- p.Glu20Lys Single submitter ⚠
- p.Glu541Gly Single submitter
- p.Glu541Lys Single submitter
- p.Gly203Val Single submitter ⚠
- p.Gly223Ser Single submitter ⚠
- p.Gly274Arg Single submitter ⚠
- p.Gly531Glu Single submitter
- p.Gly532Arg Single submitter
- p.His326Tyr Single submitter ⚠
- p.His363Gln Single submitter ⚠
- p.His461Arg Single submitter ⚠
- p.His461Tyr Single submitter ⚠
- p.Ile306Leu Single submitter ⚠
- p.Ile316Arg Single submitter ⚠
- p.Ile430Asn Single submitter ⚠
- p.Ile524Val Single submitter
- p.Leu196Gln Single submitter ⚠
- p.Leu474Val Single submitter ⚠
- p.Leu544Phe Single submitter
- p.Leu62Pro Single submitter ⚠
- p.Lys176Glu Single submitter ⚠
- p.Lys189Glu Single submitter ⚠
- p.Lys213Asn Single submitter ⚠
- p.Lys437Asn Single submitter ⚠
- p.Met137Thr Single submitter ⚠
- p.Met310Val Single submitter ⚠
- p.Phe465Ser Single submitter ⚠
- p.Phe504Ile Single submitter
- p.Pro123Arg Single submitter ⚠
- p.Pro186Gln Single submitter ⚠
- p.Pro355Leu Single submitter ⚠
- p.Pro450Leu Single submitter ⚠
- p.Pro452Arg Single submitter ⚠
- p.Pro452Ser Single submitter ⚠
- p.Pro462Gln Single submitter ⚠
- p.Ser10Ala Single submitter ⚠
- p.Thr276Ala Single submitter ⚠
- p.Thr84Asn Single submitter ⚠
- p.Trp298Cys Single submitter ⚠
- p.Trp60Gly Single submitter ⚠
- p.Tyr127Ser Single submitter ⚠
- p.Tyr138His Single submitter ⚠
- p.Tyr496Cys Single submitter ⚠
- p.Tyr86His Single submitter ⚠
- p.Val126Ile Single submitter ⚠
- p.Val158Ile Single submitter ⚠
- p.Val177Leu Single submitter ⚠
- p.Val374Met Single submitter ⚠
- p.Val449Ile Single submitter ⚠
- p.Val457Met Single submitter ⚠