Sugi Variant

Sugi Variant/ANLN

ANLN — 593 ClinVar variants

All ClinVar germline ANLN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 307 flagged for review →

1 Pathogenic · 1 Pathogenic/Likely pathogenic · 21 Conflicting · 65 Benign · 30 Benign/Likely benign · 152 Likely benign · 323 Uncertain significance

Full ANLN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 307

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 17

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 254

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 254

Predictors split 35

The independent predictors disagree with each other — read with care.

All ANLN variants

Pathogenic 1

  • p.Gly618Cys Single submitter focal segmental glomerulosclerosis 8 ⚠

Pathogenic/Likely pathogenic 1

  • p.Arg431Cys Multiple submitters focal segmental glomerulosclerosis 8

Conflicting classifications of pathogenicity 21

Benign 65

Benign/Likely benign 30

Likely benign 152

Uncertain significance 323

Showing the top 300 by review status; the full set is in the sitemap.