Sugi Variant

Sugi Variant/ANO3

ANO3 — 637 ClinVar variants

All ClinVar germline ANO3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 246 flagged for review →

5 Pathogenic · 3 Pathogenic/Likely pathogenic · 3 Likely pathogenic · 13 Conflicting · 131 Benign · 13 Benign/Likely benign · 184 Likely benign · 285 Uncertain significance

Full ANO3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 246

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 2

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 10

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 172

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 172

Predictors split 62

The independent predictors disagree with each other — read with care.

All ANO3 variants

Pathogenic 5

Pathogenic/Likely pathogenic 3

Likely pathogenic 3

Conflicting classifications of pathogenicity 13

Benign 131

Benign/Likely benign 13

Likely benign 184

Uncertain significance 285