Sugi Variant

Sugi Variant/ANO6

ANO6 — 394 ClinVar variants

All ClinVar germline ANO6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 164 flagged for review →

23 Pathogenic · 15 Likely pathogenic · 21 Conflicting · 38 Benign · 8 Benign/Likely benign · 137 Likely benign · 152 Uncertain significance

Full ANO6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 164

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 7

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 105

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 52

The independent predictors disagree with each other — read with care.

All ANO6 variants

Pathogenic 23

Likely pathogenic 15

Conflicting classifications of pathogenicity 21

Benign 38

Benign/Likely benign 8

Likely benign 137

Uncertain significance 152