ANO7 — 295 ClinVar variants
All ClinVar germline ANO7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 153 flagged for review →
76 Benign · 3 Benign/Likely benign · 22 Likely benign · 194 Uncertain significance
Full ANO7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 153
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 79
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANO7 c.-24G>A Uncertain significance Single submitter
- ANO7 c.-36G>A Uncertain significance Single submitter
- ANO7 c.-43G>A Uncertain significance Single submitter
- ANO7 c.-60G>A Uncertain significance Single submitter
- ANO7 p.Ala129Ser Uncertain significance Single submitter
- ANO7 p.Ala150Thr Uncertain significance Single submitter
- ANO7 p.Ala354Thr Uncertain significance Single submitter
- ANO7 p.Ala42Thr Uncertain significance Single submitter
- ANO7 p.Ala44Val Uncertain significance Single submitter
- ANO7 p.Ala47Gly Uncertain significance Single submitter
- ANO7 p.Ala578Thr Uncertain significance Single submitter
- ANO7 p.Ala627Val Uncertain significance Single submitter
- ANO7 p.Ala629Val Uncertain significance Single submitter
- ANO7 p.Ala722Val Uncertain significance Single submitter
- ANO7 p.Ala740Val Uncertain significance Single submitter
- ANO7 p.Arg259Cys Uncertain significance Single submitter
- ANO7 p.Arg259His Uncertain significance Single submitter
- ANO7 p.Arg362Gln Uncertain significance Single submitter
- ANO7 p.Arg441Cys Uncertain significance Single submitter
- ANO7 p.Arg477Lys Uncertain significance Single submitter
- ANO7 p.Arg489Gly Uncertain significance Single submitter
- ANO7 p.Arg54Gln Uncertain significance Single submitter
- ANO7 p.Arg573Cys Uncertain significance Single submitter
- ANO7 p.Arg619Gln Uncertain significance Single submitter
- ANO7 p.Arg691Leu Uncertain significance Single submitter
- ANO7 p.Arg691Pro Uncertain significance Single submitter
- ANO7 p.Arg751His Uncertain significance Single submitter
- ANO7 p.Asn791Thr Uncertain significance Single submitter
- ANO7 p.Asp365Glu Uncertain significance Single submitter
- ANO7 p.Asp69Glu Uncertain significance Single submitter
- ANO7 p.Asp707Asn Uncertain significance Single submitter
- ANO7 p.Asp749His Uncertain significance Single submitter
- ANO7 p.Cys126Tyr Uncertain significance Single submitter
- ANO7 p.Gln40Pro Uncertain significance Single submitter
- ANO7 p.Gln598Arg Uncertain significance Single submitter
- ANO7 p.Gln635Lys Uncertain significance Single submitter
- ANO7 p.Gln660Arg Uncertain significance Single submitter
- ANO7 p.Gln72Arg Uncertain significance Single submitter
- ANO7 p.Gln879Arg Uncertain significance Single submitter
- ANO7 p.Glu217Lys Uncertain significance Single submitter
- ANO7 p.Glu338Lys Uncertain significance Single submitter
- ANO7 p.Gly109Arg Uncertain significance Single submitter
- ANO7 p.Gly151Ser Uncertain significance Single submitter
- ANO7 p.Gly317Asp Uncertain significance Single submitter
- ANO7 p.Gly361Cys Uncertain significance Single submitter
- ANO7 p.Gly361Ser Uncertain significance Single submitter
- ANO7 p.Gly367Ser Uncertain significance Single submitter
- ANO7 p.Gly561Val Uncertain significance Single submitter
- ANO7 p.Gly628Glu Uncertain significance Single submitter
- ANO7 p.His202Gln Uncertain significance Single submitter
- ANO7 p.His748Gln Uncertain significance Single submitter
- ANO7 p.Leu262Phe Uncertain significance Single submitter
- ANO7 p.Leu330Pro Uncertain significance Single submitter
- ANO7 p.Leu394Pro Uncertain significance Single submitter
- ANO7 p.Leu877Arg Uncertain significance Single submitter
- ANO7 p.Leu99Pro Uncertain significance Single submitter
- ANO7 p.Lys536Asn Uncertain significance Single submitter
- ANO7 p.Lys612Gln Uncertain significance Single submitter
- ANO7 p.Lys873Gln Uncertain significance Single submitter
- ANO7 p.Phe206Ser Uncertain significance Single submitter
- ANO7 p.Phe319Val Uncertain significance Single submitter
- ANO7 p.Phe732Ser Uncertain significance Single submitter
- ANO7 p.Phe732Val Uncertain significance Single submitter
- ANO7 p.Pro137Ser Uncertain significance Single submitter
- ANO7 p.Pro247Thr Uncertain significance Single submitter
- ANO7 p.Pro251Leu Uncertain significance Single submitter
- ANO7 p.Pro762Arg Uncertain significance Single submitter
- ANO7 p.Pro857Leu Uncertain significance Single submitter
- ANO7 p.Ser121Cys Uncertain significance Single submitter
- ANO7 p.Ser149Leu Uncertain significance Single submitter
- ANO7 p.Ser478Leu Uncertain significance Single submitter
- ANO7 p.Ser622Phe Uncertain significance Single submitter
- ANO7 p.Thr246Met Uncertain significance Single submitter
- ANO7 p.Tyr214Phe Uncertain significance Single submitter
- ANO7 p.Tyr775Cys Uncertain significance Single submitter
- ANO7 p.Val106Ile Uncertain significance Single submitter
- ANO7 p.Val169Ile Uncertain significance Single submitter
- ANO7 p.Val451Met Uncertain significance Single submitter
- ANO7 p.Val668Leu Uncertain significance Single submitter
Predictors split 74
The independent predictors disagree with each other — read with care.
- ANO7 p.Ala705Thr Benign Multiple submitters
- ANO7 p.Arg524Cys Benign Multiple submitters
- ANO7 p.Ala116Thr Uncertain significance Single submitter
- ANO7 p.Ala236Thr Uncertain significance Single submitter
- ANO7 p.Ala294Thr Uncertain significance Single submitter
- ANO7 p.Ala306Val Likely benign Single submitter
- ANO7 p.Ala377Val Uncertain significance Single submitter
- ANO7 p.Ala392Thr Uncertain significance Single submitter
- ANO7 p.Ala415Thr Uncertain significance Single submitter
- ANO7 p.Ala416Thr Uncertain significance Single submitter
- ANO7 p.Ala484Thr Uncertain significance Single submitter
- ANO7 p.Ala487Thr Uncertain significance Single submitter
- ANO7 p.Ala767Pro Uncertain significance Single submitter
- ANO7 p.Ala767Thr Uncertain significance Single submitter
- ANO7 p.Ala798Thr Uncertain significance Single submitter
- ANO7 p.Arg185Cys Uncertain significance Single submitter
- ANO7 p.Arg282His Uncertain significance Single submitter
- ANO7 p.Arg397Cys Uncertain significance Single submitter
- ANO7 p.Arg411Gln Uncertain significance Single submitter
- ANO7 p.Arg442Cys Uncertain significance Single submitter
- ANO7 p.Arg442His Uncertain significance Single submitter
- ANO7 p.Arg442Leu Uncertain significance Single submitter
- ANO7 p.Arg489Cys Uncertain significance Single submitter
- ANO7 p.Arg54Trp Uncertain significance Single submitter
- ANO7 p.Arg573His Uncertain significance Single submitter
- ANO7 p.Arg619Trp Uncertain significance Single submitter
- ANO7 p.Arg687Cys Uncertain significance Single submitter
- ANO7 p.Arg743Trp Uncertain significance Single submitter
- ANO7 p.Arg746Pro Uncertain significance Single submitter
- ANO7 p.Arg831Trp Uncertain significance Single submitter
- ANO7 p.Arg95Cys Uncertain significance Single submitter
- ANO7 p.Arg95His Uncertain significance Single submitter
- ANO7 p.Asn160Lys Uncertain significance Single submitter
- ANO7 p.Asp193Asn Uncertain significance Single submitter
- ANO7 p.Asp241Val Uncertain significance Single submitter
- ANO7 p.Asp735Tyr Uncertain significance Single submitter
- ANO7 p.Asp735Val Uncertain significance Single submitter
- ANO7 p.Asp820His Uncertain significance Single submitter
- ANO7 p.Cys460Tyr Uncertain significance Single submitter
- ANO7 p.Cys647Trp Uncertain significance Single submitter
- ANO7 p.Gln226Glu Uncertain significance Single submitter
- ANO7 p.Glu287Lys Uncertain significance Single submitter
- ANO7 p.Glu36Lys Uncertain significance Single submitter
- ANO7 p.Glu576Gln Uncertain significance Single submitter
- ANO7 p.Gly231Arg Uncertain significance Single submitter
- ANO7 p.Gly29Arg Uncertain significance Single submitter
- ANO7 p.Gly301Val Uncertain significance Single submitter
- ANO7 p.Gly428Cys Uncertain significance Single submitter
- ANO7 p.Gly662Ser Uncertain significance Single submitter
- ANO7 p.Ile208Phe Uncertain significance Single submitter
- ANO7 p.Ile708Phe Uncertain significance Single submitter
- ANO7 p.Leu262Ile Uncertain significance Single submitter
- ANO7 p.Leu461Phe Uncertain significance Single submitter
- ANO7 p.Leu500Phe Uncertain significance Single submitter
- ANO7 p.Leu688Trp Uncertain significance Single submitter
- ANO7 p.Phe298Cys Uncertain significance Single submitter
- ANO7 p.Phe529Ser Uncertain significance Single submitter
- ANO7 p.Phe555Ile Uncertain significance Single submitter
- ANO7 p.Pro637Ser Uncertain significance Single submitter
- ANO7 p.Ser175Tyr Uncertain significance Single submitter
- ANO7 p.Ser492Ile Uncertain significance Single submitter
- ANO7 p.Ser764Phe Uncertain significance Single submitter
- ANO7 p.Thr393Met Uncertain significance Single submitter
- ANO7 p.Thr745Ala Uncertain significance Single submitter
- ANO7 p.Trp86Arg Uncertain significance Single submitter
- ANO7 p.Tyr433Ser Uncertain significance Single submitter
- ANO7 p.Tyr642His Uncertain significance Single submitter
- ANO7 p.Val281Met Uncertain significance Single submitter
- ANO7 p.Val370Met Uncertain significance Single submitter
- ANO7 p.Val462Met Uncertain significance Single submitter
- ANO7 p.Val59Ile Uncertain significance Single submitter
- ANO7 p.Val664Leu Uncertain significance Single submitter
- ANO7 p.Val701Met Uncertain significance Single submitter
- ANO7 p.Val806Met Uncertain significance Single submitter
All ANO7 variants
Benign 76
- c.1077+10G>A Multiple submitters
- c.1077+73C>A Multiple submitters
- c.108+183T>G Multiple submitters
- c.1359+129A>G Multiple submitters
- c.1359+23G>A Multiple submitters
- c.1459-5G>A Multiple submitters
- c.1561+106T>C Multiple submitters
- c.1561+64C>T Multiple submitters
- c.167-101A>C Multiple submitters
- c.1673+128G>C Multiple submitters
- c.1673+154T>C Multiple submitters
- c.1827-201C>A Multiple submitters
- c.1973-14C>T Multiple submitters
- c.2412+41G>C Multiple submitters
- c.2532+33C>G Multiple submitters
- c.2584-51C>G Multiple submitters
- c.310-241A>G Multiple submitters
- c.417+74C>T Multiple submitters
- c.418-13C>T Multiple submitters
- c.612+15C>G Multiple submitters
- c.613-96C>T Multiple submitters
- c.724-11= Multiple submitters
- c.724-240G>A Multiple submitters
- c.889+8C>T Multiple submitters
- c.-7-206C>T Multiple submitters
- c.-7-27A>G Multiple submitters
- c.*166C>T Multiple submitters
- c.*259C>T Multiple submitters
- p.Ala440Val Multiple submitters
- p.Ala705Thr Multiple submitters ⚠
- p.Arg3= Multiple submitters
- p.Arg524Cys Multiple submitters ⚠
- p.Asp102Glu Multiple submitters
- p.Asp241= Multiple submitters
- p.Glu858Lys Multiple submitters
- p.Ile686Leu Multiple submitters
- p.Pro700= Multiple submitters
- p.Ser35= Multiple submitters
- p.Thr870= Multiple submitters
- p.Tyr546= Multiple submitters
- p.Val13Ile Multiple submitters
- p.Val381Glu Multiple submitters
- c.1077+179C>A Single submitter
- c.1078-296A>G Single submitter
- c.1078-309C>T Single submitter
- c.1078-310T>C Single submitter
- c.1078-320C>T Single submitter
- c.108+245A>G Single submitter
- c.1359+191T>C Single submitter
- c.166+273T>A Single submitter
- c.167-261A>G Single submitter
- c.1673+171C>G Single submitter
- c.1729-205A>G Single submitter
- c.1972+246C>G Single submitter
- c.1973-298G>A Single submitter
- c.2178+52del Single submitter
- c.2321+131G>A Single submitter
- c.417+214G>A Single submitter
- c.554+213C>A Single submitter
- c.554+239C>T Single submitter
- c.555-286C>A Single submitter
- c.555-55_555-18del Single submitter
- c.613-297C>T Single submitter
- c.723+207C>T Single submitter
- c.889+137C>T Single submitter
- c.889+256G>A Single submitter
- c.890-271G>A Single submitter
- c.-75C>T Single submitter
- c.-8+235G>A Single submitter
- c.-8+266G>A Single submitter
- p.Asp640= Single submitter
- p.Gly215= Single submitter
- p.Gly859_Ser860insTer Single submitter
- p.Leu162= Single submitter
- p.Tyr642= Single submitter
- p.Val550Ile Single submitter
Benign/Likely benign 3
- p.Asn755= Multiple submitters
- p.Glu172Lys Multiple submitters
- p.Val475= Multiple submitters
Likely benign 22
- p.Thr427= Multiple submitters
- c.2413-1del Single submitter
- c.2489G>A Single submitter
- c.262G>A Single submitter
- c.76G>A Single submitter
- c.926G>A Single submitter
- c.-74G>A Single submitter
- p.Ala306Val Single submitter ⚠
- p.Arg177Gln Single submitter
- p.Arg25Ser Single submitter
- p.Arg79Lys Single submitter
- p.Cys343Tyr Single submitter
- p.His280= Single submitter
- p.Leu461= Single submitter
- p.Pro423Leu Single submitter
- p.Ser875fs Single submitter
- p.Thr568= Single submitter
- p.Tyr433= Single submitter
- p.Val321fs Single submitter
- p.Val451Leu Single submitter
- p.Val501Ile Single submitter
- p.Val810Ile Single submitter
Uncertain significance 194
- c.1019G>T Single submitter
- c.1202C>T Single submitter
- c.121A>G Single submitter
- c.1285T>C Single submitter
- c.1427C>T Single submitter
- c.1442C>T Single submitter
- c.1472G>A Single submitter
- c.1477C>G Single submitter
- c.1477C>T Single submitter
- c.1484G>A Single submitter
- c.1577C>T Single submitter
- c.161G>C Single submitter
- c.1643C>A Single submitter
- c.1728G>T Single submitter
- c.1788C>A Single submitter
- c.1914C>G Single submitter
- c.1957G>T Single submitter
- c.2033A>G Single submitter
- c.2099C>T Single submitter
- c.2135T>A Single submitter
- c.2188C>T Single submitter
- c.2195C>T Single submitter
- c.220C>T Single submitter
- c.2217G>T Single submitter
- c.2254C>T Single submitter
- c.2309C>T Single submitter
- c.2335A>T Single submitter
- c.2360C>G Single submitter
- c.237G>C Single submitter
- c.2384A>C Single submitter
- c.2421C>A Single submitter
- c.2435T>C Single submitter
- c.2581G>T Single submitter
- c.2627C>T Single submitter
- c.2633C>G Single submitter
- c.26C>T Single submitter
- c.2737G>A Single submitter
- c.323G>C Single submitter
- c.343G>C Single submitter
- c.392G>A Single submitter
- c.421C>T Single submitter
- c.44C>T Single submitter
- c.547G>A Single submitter
- c.743C>T Single submitter
- c.-24G>A Single submitter ⚠
- c.-36G>A Single submitter ⚠
- c.-43G>A Single submitter ⚠
- c.-60G>A Single submitter ⚠
- p.Ala116Thr Single submitter ⚠
- p.Ala129Ser Single submitter ⚠
- p.Ala150Thr Single submitter ⚠
- p.Ala236Thr Single submitter ⚠
- p.Ala294Thr Single submitter ⚠
- p.Ala354Thr Single submitter ⚠
- p.Ala377Val Single submitter ⚠
- p.Ala392Thr Single submitter ⚠
- p.Ala415Thr Single submitter ⚠
- p.Ala416Thr Single submitter ⚠
- p.Ala42Thr Single submitter ⚠
- p.Ala44Val Single submitter ⚠
- p.Ala47Gly Single submitter ⚠
- p.Ala484Thr Single submitter ⚠
- p.Ala487Thr Single submitter ⚠
- p.Ala578Thr Single submitter ⚠
- p.Ala627Val Single submitter ⚠
- p.Ala629Val Single submitter ⚠
- p.Ala722Val Single submitter ⚠
- p.Ala740Val Single submitter ⚠
- p.Ala767Pro Single submitter ⚠
- p.Ala767Thr Single submitter ⚠
- p.Ala798Thr Single submitter ⚠
- p.Arg185Cys Single submitter ⚠
- p.Arg259Cys Single submitter ⚠
- p.Arg259His Single submitter ⚠
- p.Arg282His Single submitter ⚠
- p.Arg362Gln Single submitter ⚠
- p.Arg397Cys Single submitter ⚠
- p.Arg411Gln Single submitter ⚠
- p.Arg441Cys Single submitter ⚠
- p.Arg442Cys Single submitter ⚠
- p.Arg442His Single submitter ⚠
- p.Arg442Leu Single submitter ⚠
- p.Arg477Lys Single submitter ⚠
- p.Arg489Cys Single submitter ⚠
- p.Arg489Gly Single submitter ⚠
- p.Arg54Gln Single submitter ⚠
- p.Arg54Trp Single submitter ⚠
- p.Arg573Cys Single submitter ⚠
- p.Arg573His Single submitter ⚠
- p.Arg619Gln Single submitter ⚠
- p.Arg619Trp Single submitter ⚠
- p.Arg687Cys Single submitter ⚠
- p.Arg691Leu Single submitter ⚠
- p.Arg691Pro Single submitter ⚠
- p.Arg743Trp Single submitter ⚠
- p.Arg746Pro Single submitter ⚠
- p.Arg751His Single submitter ⚠
- p.Arg831Trp Single submitter ⚠
- p.Arg95Cys Single submitter ⚠
- p.Arg95His Single submitter ⚠
- p.Asn160Lys Single submitter ⚠
- p.Asn791Thr Single submitter ⚠
- p.Asp193Asn Single submitter ⚠
- p.Asp241Val Single submitter ⚠
- p.Asp365Glu Single submitter ⚠
- p.Asp69Glu Single submitter ⚠
- p.Asp707Asn Single submitter ⚠
- p.Asp735Tyr Single submitter ⚠
- p.Asp735Val Single submitter ⚠
- p.Asp749His Single submitter ⚠
- p.Asp820His Single submitter ⚠
- p.Cys126Tyr Single submitter ⚠
- p.Cys460Tyr Single submitter ⚠
- p.Cys647Trp Single submitter ⚠
- p.Gln226Glu Single submitter ⚠
- p.Gln40Pro Single submitter ⚠
- p.Gln598Arg Single submitter ⚠
- p.Gln635Lys Single submitter ⚠
- p.Gln660Arg Single submitter ⚠
- p.Gln72Arg Single submitter ⚠
- p.Gln879Arg Single submitter ⚠
- p.Glu217Lys Single submitter ⚠
- p.Glu287Lys Single submitter ⚠
- p.Glu338Lys Single submitter ⚠
- p.Glu36Lys Single submitter ⚠
- p.Glu576Gln Single submitter ⚠
- p.Gly109Arg Single submitter ⚠
- p.Gly151Ser Single submitter ⚠
- p.Gly231Arg Single submitter ⚠
- p.Gly29Arg Single submitter ⚠
- p.Gly301Val Single submitter ⚠
- p.Gly317Asp Single submitter ⚠
- p.Gly361Cys Single submitter ⚠
- p.Gly361Ser Single submitter ⚠
- p.Gly367Ser Single submitter ⚠
- p.Gly428Cys Single submitter ⚠
- p.Gly561Val Single submitter ⚠
- p.Gly628Glu Single submitter ⚠
- p.Gly662Ser Single submitter ⚠
- p.His202Gln Single submitter ⚠
- p.His748Gln Single submitter ⚠
- p.Ile208Phe Single submitter ⚠
- p.Ile708Phe Single submitter ⚠
- p.Leu262Ile Single submitter ⚠
- p.Leu262Phe Single submitter ⚠
- p.Leu330Pro Single submitter ⚠
- p.Leu394Pro Single submitter ⚠
- p.Leu461Phe Single submitter ⚠
- p.Leu500Phe Single submitter ⚠
- p.Leu688Trp Single submitter ⚠
- p.Leu877Arg Single submitter ⚠
- p.Leu99Pro Single submitter ⚠
- p.Lys536Asn Single submitter ⚠
- p.Lys612Gln Single submitter ⚠
- p.Lys873Gln Single submitter ⚠
- p.Phe206Ser Single submitter ⚠
- p.Phe298Cys Single submitter ⚠
- p.Phe319Val Single submitter ⚠
- p.Phe529Ser Single submitter ⚠
- p.Phe555Ile Single submitter ⚠
- p.Phe732Ser Single submitter ⚠
- p.Phe732Val Single submitter ⚠
- p.Pro137Ser Single submitter ⚠
- p.Pro247Thr Single submitter ⚠
- p.Pro251Leu Single submitter ⚠
- p.Pro637Ser Single submitter ⚠
- p.Pro762Arg Single submitter ⚠
- p.Pro857Leu Single submitter ⚠
- p.Ser121Cys Single submitter ⚠
- p.Ser149Leu Single submitter ⚠
- p.Ser175Tyr Single submitter ⚠
- p.Ser478Leu Single submitter ⚠
- p.Ser492Ile Single submitter ⚠
- p.Ser622Phe Single submitter ⚠
- p.Ser764Phe Single submitter ⚠
- p.Thr246Met Single submitter ⚠
- p.Thr393Met Single submitter ⚠
- p.Thr745Ala Single submitter ⚠
- p.Trp86Arg Single submitter ⚠
- p.Tyr214Phe Single submitter ⚠
- p.Tyr433Ser Single submitter ⚠
- p.Tyr642His Single submitter ⚠
- p.Tyr775Cys Single submitter ⚠
- p.Val106Ile Single submitter ⚠
- p.Val169Ile Single submitter ⚠
- p.Val281Met Single submitter ⚠
- p.Val370Met Single submitter ⚠
- p.Val451Met Single submitter ⚠
- p.Val462Met Single submitter ⚠
- p.Val59Ile Single submitter ⚠
- p.Val664Leu Single submitter ⚠
- p.Val668Leu Single submitter ⚠
- p.Val701Met Single submitter ⚠
- p.Val806Met Single submitter ⚠