ANP32A — 11 ClinVar variants
All ClinVar germline ANP32A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
2 Benign · 1 Likely benign · 8 Uncertain significance
Full ANP32A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All ANP32A variants
Benign 2
- p.Arg237= Multiple submitters
- c.55-10C>G Single submitter
Likely benign 1
- p.Asp193Glu Single submitter
Uncertain significance 8
- c.55-1G>C Single submitter
- p.Arg239fs Single submitter
- p.Asp249Asn Single submitter ⚠
- p.Gln235Arg Single submitter ⚠
- p.Val185Ile Single submitter ⚠
- p.Val186Met Single submitter ⚠
- p.Val203Met Single submitter ⚠
- p.Val52Ile Single submitter ⚠