ANP32B — 27 ClinVar variants
All ClinVar germline ANP32B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
3 Benign · 2 Likely benign · 22 Uncertain significance
Full ANP32B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANP32B p.Arg150Gln Uncertain significance Single submitter
- ANP32B p.Arg20Gln Uncertain significance Single submitter
- ANP32B p.Asn59His Uncertain significance Single submitter
- ANP32B p.Asp203Val Uncertain significance Single submitter
- ANP32B p.Glu170Asp Uncertain significance Single submitter
- ANP32B p.Glu193Asp Uncertain significance Single submitter
- ANP32B p.Glu225Asp Uncertain significance Single submitter
- ANP32B p.Gly147Ser Uncertain significance Single submitter
- ANP32B p.Met82Arg Uncertain significance Single submitter
- ANP32B p.Met82Val Uncertain significance Single submitter
- ANP32B p.Ser134Arg Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- ANP32B p.Ala84Thr Uncertain significance Single submitter
- ANP32B p.Ala84Val Uncertain significance Single submitter
- ANP32B p.Arg242Lys Uncertain significance Single submitter
- ANP32B p.Asp184Asn Uncertain significance Single submitter
- ANP32B p.Asp203His Uncertain significance Single submitter
- ANP32B p.Asp245His Uncertain significance Single submitter
- ANP32B p.Glu180Lys Uncertain significance Single submitter
- ANP32B p.Leu71Phe Uncertain significance Single submitter
- ANP32B p.Met3Ile Uncertain significance Single submitter
- ANP32B p.Thr15Ile Uncertain significance Single submitter
All ANP32B variants
Benign 3
- c.54+11A>G Multiple submitters
- p.Asp130Ala Multiple submitters
- p.Asp181= Single submitter
Uncertain significance 22
- p.Ala84Thr Single submitter ⚠
- p.Ala84Val Single submitter ⚠
- p.Arg150Gln Single submitter ⚠
- p.Arg20Gln Single submitter ⚠
- p.Arg242Lys Single submitter ⚠
- p.Arg75fs Single submitter
- p.Asn59His Single submitter ⚠
- p.Asp184Asn Single submitter ⚠
- p.Asp203His Single submitter ⚠
- p.Asp203Val Single submitter ⚠
- p.Asp245His Single submitter ⚠
- p.Glu170Asp Single submitter ⚠
- p.Glu180Lys Single submitter ⚠
- p.Glu193Asp Single submitter ⚠
- p.Glu225Asp Single submitter ⚠
- p.Gly147Ser Single submitter ⚠
- p.Leu71Phe Single submitter ⚠
- p.Met3Ile Single submitter ⚠
- p.Met82Arg Single submitter ⚠
- p.Met82Val Single submitter ⚠
- p.Ser134Arg Single submitter ⚠
- p.Thr15Ile Single submitter ⚠