ANP32E — 16 ClinVar variants
All ClinVar germline ANP32E variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
16 Uncertain significance
Full ANP32E gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANP32E p.Asp102Glu Uncertain significance Single submitter
- ANP32E p.Asp162Glu Uncertain significance Single submitter
- ANP32E p.Gly249Asp Uncertain significance Single submitter
- ANP32E p.Pro181Leu Uncertain significance Single submitter
- ANP32E p.Ser117Gly Uncertain significance Single submitter
- ANP32E p.Ser134Asn Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- ANP32E p.Asp162Val Uncertain significance Single submitter
- ANP32E p.Asp262Asn Uncertain significance Single submitter
- ANP32E p.Glu151Lys Uncertain significance Single submitter
- ANP32E p.Glu187Asp Uncertain significance Single submitter
- ANP32E p.Glu187Lys Uncertain significance Single submitter
- ANP32E p.Glu238Gly Uncertain significance Single submitter
- ANP32E p.Glu243Lys Uncertain significance Single submitter
- ANP32E p.Glu245Gly Uncertain significance Single submitter
- ANP32E p.Gly212Arg Uncertain significance Single submitter
- ANP32E p.Tyr184Cys Uncertain significance Single submitter
All ANP32E variants
Uncertain significance 16
- p.Asp102Glu Single submitter ⚠
- p.Asp162Glu Single submitter ⚠
- p.Asp162Val Single submitter ⚠
- p.Asp262Asn Single submitter ⚠
- p.Glu151Lys Single submitter ⚠
- p.Glu187Asp Single submitter ⚠
- p.Glu187Lys Single submitter ⚠
- p.Glu238Gly Single submitter ⚠
- p.Glu243Lys Single submitter ⚠
- p.Glu245Gly Single submitter ⚠
- p.Gly212Arg Single submitter ⚠
- p.Gly249Asp Single submitter ⚠
- p.Pro181Leu Single submitter ⚠
- p.Ser117Gly Single submitter ⚠
- p.Ser134Asn Single submitter ⚠
- p.Tyr184Cys Single submitter ⚠