Sugi Variant

Sugi Variant/ANTXR1

ANTXR1 — 193 ClinVar variants

All ClinVar germline ANTXR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 81 flagged for review →

1 Pathogenic · 1 Pathogenic/Likely pathogenic · 9 Likely pathogenic · 3 Conflicting · 64 Benign · 2 Benign/Likely benign · 35 Likely benign · 78 Uncertain significance

Full ANTXR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 81

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 44

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 34

The independent predictors disagree with each other — read with care.

All ANTXR1 variants

Pathogenic 1

Pathogenic/Likely pathogenic 1

Likely pathogenic 9

Conflicting classifications of pathogenicity 3

Benign 64

Benign/Likely benign 2

Likely benign 35

Uncertain significance 78