ANXA10 — 37 ClinVar variants
All ClinVar germline ANXA10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
2 Benign · 2 Likely benign · 33 Uncertain significance
Full ANXA10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANXA10 p.Ala130Thr Uncertain significance Single submitter
- ANXA10 p.Ala171Val Uncertain significance Single submitter
- ANXA10 p.Ala315Gly Uncertain significance Single submitter
- ANXA10 p.Arg208Gln Uncertain significance Single submitter
- ANXA10 p.Arg292Leu Uncertain significance Single submitter
- ANXA10 p.Arg65Gln Uncertain significance Single submitter
- ANXA10 p.Asp224Val Uncertain significance Single submitter
- ANXA10 p.Asp247Asn Uncertain significance Single submitter
- ANXA10 p.Asp323Asn Uncertain significance Single submitter
- ANXA10 p.Glu291Gln Uncertain significance Single submitter
- ANXA10 p.Glu322Lys Uncertain significance Single submitter
- ANXA10 p.Gly122Arg Uncertain significance Single submitter
- ANXA10 p.Leu297Gln Uncertain significance Single submitter
- ANXA10 p.Leu297Pro Uncertain significance Single submitter
- ANXA10 p.Leu67Pro Uncertain significance Single submitter
- ANXA10 p.Lys192Arg Uncertain significance Single submitter
- ANXA10 p.Lys192Thr Uncertain significance Single submitter
- ANXA10 p.Met21Ile Uncertain significance Single submitter
- ANXA10 p.Met62Thr Uncertain significance Single submitter
- ANXA10 p.Met87Ile Uncertain significance Single submitter
- ANXA10 p.Met87Lys Uncertain significance Single submitter
- ANXA10 p.Phe33Leu Uncertain significance Single submitter
- ANXA10 p.Pro90Ser Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- ANXA10 p.Ala225Asp Uncertain significance Single submitter
- ANXA10 p.Arg47His Uncertain significance Single submitter
- ANXA10 p.Arg65Trp Uncertain significance Single submitter
- ANXA10 p.Asp142Asn Uncertain significance Single submitter
- ANXA10 p.Asp281Asn Uncertain significance Single submitter
- ANXA10 p.Glu279Asp Uncertain significance Single submitter
- ANXA10 p.Ser296Phe Uncertain significance Single submitter
- ANXA10 p.Ser76Leu Uncertain significance Single submitter
All ANXA10 variants
Benign 2
- p.Ile241Thr Multiple submitters
- p.Leu195Val Multiple submitters
Likely benign 2
- p.Arg208Trp Single submitter
- p.Arg72Lys Single submitter
Uncertain significance 33
- p.Ala130Thr Single submitter ⚠
- p.Ala171Val Single submitter ⚠
- p.Ala225Asp Single submitter ⚠
- p.Ala259Val Single submitter
- p.Ala315Gly Single submitter ⚠
- p.Arg208Gln Single submitter ⚠
- p.Arg292Leu Single submitter ⚠
- p.Arg47His Single submitter ⚠
- p.Arg65Gln Single submitter ⚠
- p.Arg65Trp Single submitter ⚠
- p.Asp142Asn Single submitter ⚠
- p.Asp224Val Single submitter ⚠
- p.Asp247Asn Single submitter ⚠
- p.Asp281Asn Single submitter ⚠
- p.Asp323Asn Single submitter ⚠
- p.Glu279Asp Single submitter ⚠
- p.Glu291Gln Single submitter ⚠
- p.Glu322Lys Single submitter ⚠
- p.Gly122Arg Single submitter ⚠
- p.Leu297Gln Single submitter ⚠
- p.Leu297Pro Single submitter ⚠
- p.Leu67Pro Single submitter ⚠
- p.Lys192Arg Single submitter ⚠
- p.Lys192Thr Single submitter ⚠
- p.Met21Ile Single submitter ⚠
- p.Met62Thr Single submitter ⚠
- p.Met87Ile Single submitter ⚠
- p.Met87Lys Single submitter ⚠
- p.Phe33Leu Single submitter ⚠
- p.Pro90Ser Single submitter ⚠
- p.Ser296Phe Single submitter ⚠
- p.Ser76Leu Single submitter ⚠
- p.Tyr135Cys Single submitter