ANXA13 — 69 ClinVar variants
All ClinVar germline ANXA13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
5 Likely benign · 64 Uncertain significance
Full ANXA13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANXA13 p.Ala26Val Uncertain significance Single submitter
- ANXA13 p.Ala80Val Uncertain significance Single submitter
- ANXA13 p.Ala8Val Uncertain significance Single submitter
- ANXA13 p.Ala91Val Uncertain significance Single submitter
- ANXA13 p.Arg18Gln Uncertain significance Single submitter
- ANXA13 p.Arg4Cys Uncertain significance Single submitter
- ANXA13 p.Asn161Lys Uncertain significance Single submitter
- ANXA13 p.Asp143Gly Uncertain significance Single submitter
- ANXA13 p.Gln292His Uncertain significance Single submitter
- ANXA13 p.Gly305Arg Uncertain significance Single submitter
- ANXA13 p.Ile220Lys Uncertain significance Single submitter
- ANXA13 p.Leu197Arg Uncertain significance Single submitter
- ANXA13 p.Leu197Pro Uncertain significance Single submitter
- ANXA13 p.Lys203Arg Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- ANXA13 p.Ala127Thr Uncertain significance Single submitter
- ANXA13 p.Ala251Val Uncertain significance Single submitter
- ANXA13 p.Ala313Val Uncertain significance Single submitter
- ANXA13 p.Arg185His Uncertain significance Single submitter
- ANXA13 p.Arg253Cys Uncertain significance Single submitter
- ANXA13 p.Arg253His Uncertain significance Single submitter
- ANXA13 p.Arg86Cys Uncertain significance Single submitter
- ANXA13 p.Arg93Trp Uncertain significance Single submitter
- ANXA13 p.Asn194Ser Uncertain significance Single submitter
- ANXA13 p.Asp169Gly Uncertain significance Single submitter
- ANXA13 p.Asp231Asn Uncertain significance Single submitter
- ANXA13 p.Asp245His Uncertain significance Single submitter
- ANXA13 p.Asp264Asn Uncertain significance Single submitter
- ANXA13 p.Asp297Ala Uncertain significance Single submitter
- ANXA13 p.Glu137Lys Uncertain significance Single submitter
- ANXA13 p.Glu183Gln Uncertain significance Single submitter
- ANXA13 p.Glu277Lys Uncertain significance Single submitter
- ANXA13 p.Glu89Lys Uncertain significance Single submitter
- ANXA13 p.Gly260Ser Uncertain significance Single submitter
- ANXA13 p.Gly43Val Uncertain significance Single submitter
- ANXA13 p.Gly61Ser Uncertain significance Single submitter
- ANXA13 p.Leu156Met Uncertain significance Single submitter
- ANXA13 p.Leu178Met Uncertain significance Single submitter
- ANXA13 p.Leu68Phe Uncertain significance Single submitter
- ANXA13 p.Leu83Phe Uncertain significance Single submitter
- ANXA13 p.Lys119Thr Uncertain significance Single submitter
- ANXA13 p.Lys150Ile Uncertain significance Single submitter
- ANXA13 p.Met99Thr Uncertain significance Single submitter
- ANXA13 p.Ser70Asn Uncertain significance Single submitter
- ANXA13 p.Ser73Asn Uncertain significance Single submitter
- ANXA13 p.Thr115Met Uncertain significance Single submitter
- ANXA13 p.Thr115Pro Uncertain significance Single submitter
- ANXA13 p.Thr117Pro Uncertain significance Single submitter
- ANXA13 p.Thr144Ala Uncertain significance Single submitter
- ANXA13 p.Thr144Ser Uncertain significance Single submitter
- ANXA13 p.Trp186Cys Uncertain significance Single submitter
- ANXA13 p.Tyr255His Uncertain significance Single submitter
- ANXA13 p.Val166Met Uncertain significance Single submitter
- ANXA13 p.Val273Met Uncertain significance Single submitter
All ANXA13 variants
Likely benign 5
- c.15+1510T>C Single submitter
- c.15+1540A>G Single submitter
- p.Arg308Gln Single submitter
- p.Asp47Glu Single submitter
- p.Glu77Lys Single submitter
Uncertain significance 64
- c.15+1450C>T Single submitter
- c.15+1476C>A Single submitter
- c.15+1477A>C Single submitter
- c.15+1513T>G Single submitter
- c.15+1518C>A Single submitter
- c.15+1525G>A Single submitter
- c.15+1529C>A Single submitter
- c.15+1536C>T Single submitter
- c.15+1537G>A Single submitter
- c.15+1543G>C Single submitter
- c.15+1546A>T Single submitter
- p.Ala127Thr Single submitter ⚠
- p.Ala251Val Single submitter ⚠
- p.Ala26Val Single submitter ⚠
- p.Ala313Val Single submitter ⚠
- p.Ala80Val Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Ala91Val Single submitter ⚠
- p.Arg185His Single submitter ⚠
- p.Arg18Gln Single submitter ⚠
- p.Arg253Cys Single submitter ⚠
- p.Arg253His Single submitter ⚠
- p.Arg4Cys Single submitter ⚠
- p.Arg86Cys Single submitter ⚠
- p.Arg93Trp Single submitter ⚠
- p.Asn161Lys Single submitter ⚠
- p.Asn194Ser Single submitter ⚠
- p.Asp143Gly Single submitter ⚠
- p.Asp169Gly Single submitter ⚠
- p.Asp231Asn Single submitter ⚠
- p.Asp245His Single submitter ⚠
- p.Asp264Asn Single submitter ⚠
- p.Asp297Ala Single submitter ⚠
- p.Gln292His Single submitter ⚠
- p.Glu137Lys Single submitter ⚠
- p.Glu183Gln Single submitter ⚠
- p.Glu277Lys Single submitter ⚠
- p.Glu89Lys Single submitter ⚠
- p.Gly260Ser Single submitter ⚠
- p.Gly305Arg Single submitter ⚠
- p.Gly43Val Single submitter ⚠
- p.Gly61Ser Single submitter ⚠
- p.Ile220Lys Single submitter ⚠
- p.Leu156Met Single submitter ⚠
- p.Leu178Met Single submitter ⚠
- p.Leu197Arg Single submitter ⚠
- p.Leu197Pro Single submitter ⚠
- p.Leu68Phe Single submitter ⚠
- p.Leu83Phe Single submitter ⚠
- p.Lys119Thr Single submitter ⚠
- p.Lys150Ile Single submitter ⚠
- p.Lys203Arg Single submitter ⚠
- p.Met99Thr Single submitter ⚠
- p.Ser70Asn Single submitter ⚠
- p.Ser73Asn Single submitter ⚠
- p.Thr115Met Single submitter ⚠
- p.Thr115Pro Single submitter ⚠
- p.Thr117Pro Single submitter ⚠
- p.Thr144Ala Single submitter ⚠
- p.Thr144Ser Single submitter ⚠
- p.Trp186Cys Single submitter ⚠
- p.Tyr255His Single submitter ⚠
- p.Val166Met Single submitter ⚠
- p.Val273Met Single submitter ⚠