ANXA2 — 26 ClinVar variants
All ClinVar germline ANXA2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Benign · 25 Uncertain significance
Full ANXA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANXA2 p.Arg220Trp Uncertain significance Single submitter
- ANXA2 p.Arg63His Uncertain significance Single submitter
- ANXA2 p.Asp194His Uncertain significance Single submitter
- ANXA2 p.Gln67His Uncertain significance Single submitter
- ANXA2 p.Glu96Val Uncertain significance Single submitter
- ANXA2 p.Gly250Glu Uncertain significance Single submitter
- ANXA2 p.Lys169Glu Uncertain significance Single submitter
- ANXA2 p.Met171Thr Uncertain significance Single submitter
- ANXA2 p.Met278Ile Uncertain significance Single submitter
- ANXA2 p.Pro20Thr Uncertain significance Single submitter
- ANXA2 p.Thr283Met Uncertain significance Single submitter
- ANXA2 p.Val4Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- ANXA2 p.Asn265Ser Uncertain significance Single submitter
- ANXA2 p.Gln261His Uncertain significance Single submitter
- ANXA2 p.Gln69Arg Uncertain significance Single submitter
- ANXA2 p.Ile160Phe Uncertain significance Single submitter
- ANXA2 p.Ile214Val Uncertain significance Single submitter
- ANXA2 p.Leu121Met Uncertain significance Single submitter
- ANXA2 p.Lys169Asn Uncertain significance Single submitter
- ANXA2 p.Met292Ile Uncertain significance Single submitter
- ANXA2 p.Met292Leu Uncertain significance Single submitter
- ANXA2 p.Tyr147Phe Uncertain significance Single submitter
- ANXA2 p.Tyr30His Uncertain significance Single submitter
All ANXA2 variants
Benign 1
- p.Val98Leu Multiple submitters
Uncertain significance 25
- c.-12+42C>G Single submitter
- c.-12+64G>A Single submitter
- p.Arg220Trp Single submitter ⚠
- p.Arg63His Single submitter ⚠
- p.Asn265Ser Single submitter ⚠
- p.Asp194His Single submitter ⚠
- p.Gln261His Single submitter ⚠
- p.Gln67His Single submitter ⚠
- p.Gln69Arg Single submitter ⚠
- p.Glu96Val Single submitter ⚠
- p.Gly250Glu Single submitter ⚠
- p.Ile160Phe Single submitter ⚠
- p.Ile214Val Single submitter ⚠
- p.Leu121Met Single submitter ⚠
- p.Lys169Asn Single submitter ⚠
- p.Lys169Glu Single submitter ⚠
- p.Met171Thr Single submitter ⚠
- p.Met278Ile Single submitter ⚠
- p.Met292Ile Single submitter ⚠
- p.Met292Leu Single submitter ⚠
- p.Pro20Thr Single submitter ⚠
- p.Thr283Met Single submitter ⚠
- p.Tyr147Phe Single submitter ⚠
- p.Tyr30His Single submitter ⚠
- p.Val4Ile Single submitter ⚠