ANXA3 — 62 ClinVar variants
All ClinVar germline ANXA3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
2 Benign · 2 Likely benign · 58 Uncertain significance
Full ANXA3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ANXA3 p.Arg123Lys Uncertain significance Single submitter
- ANXA3 p.Arg153Gln Uncertain significance Single submitter
- ANXA3 p.Arg274Pro Uncertain significance Single submitter
- ANXA3 p.Arg9Gln Uncertain significance Single submitter
- ANXA3 p.Asn188Asp Uncertain significance Single submitter
- ANXA3 p.Asp37Asn Uncertain significance Single submitter
- ANXA3 p.Asp95Asn Uncertain significance Single submitter
- ANXA3 p.Glu312Lys Uncertain significance Single submitter
- ANXA3 p.Glu47Lys Uncertain significance Single submitter
- ANXA3 p.Gly141Glu Uncertain significance Single submitter
- ANXA3 p.Gly234Ala Uncertain significance Single submitter
- ANXA3 p.Gly35Val Uncertain significance Single submitter
- ANXA3 p.Ile200Val Uncertain significance Single submitter
- ANXA3 p.Ile34Phe Uncertain significance Single submitter
- ANXA3 p.Ile4Leu Uncertain significance Single submitter
- ANXA3 p.Lys317Arg Uncertain significance Single submitter
- ANXA3 p.Met84Ile Uncertain significance Single submitter
- ANXA3 p.Ser19Arg Uncertain significance Single submitter
- ANXA3 p.Ser205Arg Uncertain significance Single submitter
- ANXA3 p.Thr118Ala Uncertain significance Single submitter
- ANXA3 p.Thr192Lys Uncertain significance Single submitter
- ANXA3 p.Thr267Asn Uncertain significance Single submitter
- ANXA3 p.Trp5Ser Uncertain significance Single submitter
- ANXA3 p.Tyr311Ser Uncertain significance Single submitter
- ANXA3 p.Val88Leu Uncertain significance Single submitter
- ANXA3 p.Val93Leu Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- ANXA3 p.Ile219Asn Benign Multiple submitters
- ANXA3 p.Ala112Gly Uncertain significance Single submitter
- ANXA3 p.Ala24Val Uncertain significance Single submitter
- ANXA3 p.Arg274Gln Uncertain significance Single submitter
- ANXA3 p.Arg53Trp Uncertain significance Single submitter
- ANXA3 p.Asp165Glu Uncertain significance Single submitter
- ANXA3 p.Asp310Tyr Uncertain significance Single submitter
- ANXA3 p.Gln221Pro Uncertain significance Single submitter
- ANXA3 p.Glu147Lys Uncertain significance Single submitter
- ANXA3 p.Glu166Lys Uncertain significance Single submitter
- ANXA3 p.Glu194Lys Uncertain significance Single submitter
- ANXA3 p.Glu256Lys Uncertain significance Single submitter
- ANXA3 p.Glu59Lys Uncertain significance Single submitter
- ANXA3 p.Gly65Val Uncertain significance Single submitter
- ANXA3 p.Ile31Thr Uncertain significance Single submitter
- ANXA3 p.Lys29Asn Uncertain significance Single submitter
- ANXA3 p.Phe213Ile Uncertain significance Single submitter
- ANXA3 p.Pro91Ala Uncertain significance Single submitter
- ANXA3 p.Ser102Phe Uncertain significance Single submitter
- ANXA3 p.Ser122Arg Uncertain significance Single submitter
- ANXA3 p.Ser139Gly Uncertain significance Single submitter
- ANXA3 p.Ser21Leu Uncertain significance Single submitter
- ANXA3 p.Ser305Leu Uncertain significance Single submitter
- ANXA3 p.Ser49Pro Uncertain significance Single submitter
- ANXA3 p.Thr121Ile Uncertain significance Single submitter
- ANXA3 p.Thr192Met Uncertain significance Single submitter
- ANXA3 p.Thr198Ser Uncertain significance Single submitter
- ANXA3 p.Thr267Ser Uncertain significance Single submitter
- ANXA3 p.Thr314Lys Uncertain significance Single submitter
- ANXA3 p.Thr46Ile Uncertain significance Single submitter
- ANXA3 p.Tyr183His Uncertain significance Single submitter
- ANXA3 p.Val12Gly Uncertain significance Single submitter
- ANXA3 p.Val57Phe Uncertain significance Single submitter
All ANXA3 variants
Benign 2
- p.Ile219Asn Multiple submitters ⚠
- p.Ser19Asn Multiple submitters
Likely benign 2
- p.Ala106Thr Single submitter
- p.Ile313Thr Single submitter
Uncertain significance 58
- p.Ala112Gly Single submitter ⚠
- p.Ala24Val Single submitter ⚠
- p.Arg123Lys Single submitter ⚠
- p.Arg153Gln Single submitter ⚠
- p.Arg274Gln Single submitter ⚠
- p.Arg274Pro Single submitter ⚠
- p.Arg53Trp Single submitter ⚠
- p.Arg9Gln Single submitter ⚠
- p.Asn188Asp Single submitter ⚠
- p.Asp165Glu Single submitter ⚠
- p.Asp310Tyr Single submitter ⚠
- p.Asp37Asn Single submitter ⚠
- p.Asp95Asn Single submitter ⚠
- p.Gln221Pro Single submitter ⚠
- p.Glu147Lys Single submitter ⚠
- p.Glu166Lys Single submitter ⚠
- p.Glu194Lys Single submitter ⚠
- p.Glu256Lys Single submitter ⚠
- p.Glu312Lys Single submitter ⚠
- p.Glu47Lys Single submitter ⚠
- p.Glu59Lys Single submitter ⚠
- p.Gly141Glu Single submitter ⚠
- p.Gly234Ala Single submitter ⚠
- p.Gly35Val Single submitter ⚠
- p.Gly65Val Single submitter ⚠
- p.Ile200Val Single submitter ⚠
- p.Ile31Thr Single submitter ⚠
- p.Ile34Phe Single submitter ⚠
- p.Ile4Leu Single submitter ⚠
- p.Lys29Asn Single submitter ⚠
- p.Lys317Arg Single submitter ⚠
- p.Met84Ile Single submitter ⚠
- p.Phe213Ile Single submitter ⚠
- p.Pro91Ala Single submitter ⚠
- p.Ser102Phe Single submitter ⚠
- p.Ser122Arg Single submitter ⚠
- p.Ser139Gly Single submitter ⚠
- p.Ser19Arg Single submitter ⚠
- p.Ser205Arg Single submitter ⚠
- p.Ser21Leu Single submitter ⚠
- p.Ser305Leu Single submitter ⚠
- p.Ser49Pro Single submitter ⚠
- p.Thr118Ala Single submitter ⚠
- p.Thr121Ile Single submitter ⚠
- p.Thr192Lys Single submitter ⚠
- p.Thr192Met Single submitter ⚠
- p.Thr198Ser Single submitter ⚠
- p.Thr267Asn Single submitter ⚠
- p.Thr267Ser Single submitter ⚠
- p.Thr314Lys Single submitter ⚠
- p.Thr46Ile Single submitter ⚠
- p.Trp5Ser Single submitter ⚠
- p.Tyr183His Single submitter ⚠
- p.Tyr311Ser Single submitter ⚠
- p.Val12Gly Single submitter ⚠
- p.Val57Phe Single submitter ⚠
- p.Val88Leu Single submitter ⚠
- p.Val93Leu Single submitter ⚠